Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women

Toxicology Letters

Volumn 219, Issue 3, 2013, Pages 269-278

  Kobayashi, Sumitaka ^a   Sata, Fumihiro ^b   Sasaki, Seiko ^a   Ban, Susumu ^c   Miyashita, Chihiro ^d   Okada, Emiko ^a   Limpar, Mariko ^a   Yoshioka, Eiji ^e   Kajiwara, Jumboku ^f   Todaka, Takashi ^g   Saijo, Yasuaki ^e   Kishi, Reiko ^d  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

^e ASAHIKAWA MEDICAL COLLEGE   (Japan)

^f FUKUOKA INSTITUTE OF HEALTH AND ENVIRONMENTAL SCIENCES   (Japan)

^g KYUSHU UNIVERSITY   (Japan)

Author keywords

Aromatic hydrocarbon receptor; Blood; Cytochrome P450; Dioxin; Single nucleotide polymorphism

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; DIBENZOFURAN; DIOXIN;

ADULT; ARTICLE; BLOOD ANALYSIS; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN EXPERIMENT; JAPANESE; MAJOR CLINICAL STUDY; NORMAL HUMAN; PREGNANT WOMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CYTOCHROME P-450 CYP1A1; DIOXINS; FEMALE; GENES, DOMINANT; GENES, RECESSIVE; GENOTYPE; HUMANS; JAPAN; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY;

EID: 84877322299     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.03.013     Document Type: Article

References (63)

1. Babu K.A., Rao K.L., Kanakavalli M.K., Suryanarayana V.V., Deenadayal M., Singh L. CYP1A1, GSTM1, and GSTT1 genetic polymorphism is associated with susceptibility to polycystic ovaries in South Indian women. Reproductive Biomedicine Online 2004, 9:194-200.
2. Barouki R., Coumoul X., Fernandez-Salguero P.M. The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein. FEBS Letters 2007, 581:3608-3615.
3. Berwick M., Matullo G., Song Y.S., Guarrera S., Dominguez G., Orlow I., Walker M., Vineis P. Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma. Journal of Clinical Oncology 2004, 22:3997-4001.
4. Chao H.R., Wang S.L., Lin L.Y., Lee W.J., Päpke O. Placental transfer of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in Taiwanese mothers in relation to menstrual cycle characteristics. Food and Chemical Toxicology 2007, 45:259-265.
5. Delpisheh A., Brabin L., Topping J., Reyad M., Tang A.W., Brabin B.J. A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction. European Journal of Obstetrics & Gynecology and Reproductive Biology 2009, 143:38-42.
6. DeVito M.J., Ménache M.G., Diliberto J.J., Ross D.G., Birnbarm L.S. Dose-response relationships for induction of CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin in female mice following subchronic exposure to polychlorinated biphenyls. Toxicology & Applied Pharmacology 2000, 167:157-172.
7. Gim J., Kim H.S., Kim J., Choi M., Kim J.R., Chung Y.J., Cho K.H. A system-level investigation into the cellular toxic response mechanism mediated by AhR signal transduction pathway. Bioinformatics 2010, 26:2169-2175.
8. Gupta M., McDougal A., Safe S. Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells. The Journal of Steroid Biochemistry & Molecular Biology 1998, 67:413-419.
9. Hayes C.L., Spink D.C., Spink B.C., Cao J.Q., Walker N.J., Sutter T.R. 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proceedings of National Academy of Science of United States of America 1996, 93:9776-9781.
10. Helmig S., Seelinger J.U., Döhrel J., Schneider J. RNA expressions of AHR, ARNT and CYP1B1 are influenced by AHR Arg554Lys polymorphism. Molecular Genetics & Metabolism 2011, 104:180-184.
11. 185 variants repress both AHR and hypoxia-inducible factor. Molecular & Cellular Biology 2009, 29:3465-3477.
12. Kim S.H., Choi Y.M., Lee G.H., Hong M.A., Lee K.S., Lee B.S., Kim J.G., Moon S.Y. Association between susceptibility to advanced stage endometriosis and the genetic polymorphisms of aryl hydrocarbon receptor repressor and glutathione-S-transferase T1 genes. Human Reproduction 2007, 22:1866-1870.
13. Kishi R., Sasaki S., Yoshioka E., Yuasa M., Sata F., Saijo Y., Kurahashi N., Tamaki J., Endo T., Sengoku K., Nonomura K., Minakami H., Hokkaido Study on Environment and Children's Health Cohort profile: the Hokkaido study on environment and children's health in Japan. International Journal of Epidemiology 2007, 40:611-618.
14. Klein K., Winter S., Turpeinen M., Schwab M., Zanger U.M. Pathway-targeted pharmacogenomics of CYP1A2 in human liver. Frontiers in Pharmacology 2010, 1:129.
15. Konishi K., Sasaki S., Kato S., Ban S., Washino N., Kajiwara J., Todaka T., Hirakawa H., Hori T., Yasutake D., Kishi R. Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight. Environment Research 2009, 109:906-913.
16. Kwakkel J., Wiersinga W.M., Boelen A. Interleukin-1beta modulates endogenous thyroid hormone receptor alpha gene transcription in liver cells. Journal of Endocrinology 2007, 194:257-265.
17. Landi M.T., Bertazzi P.A., Shields P.G., Clark G., Lucier G.W., Garte S.J., Cosma G., Caporaso N.E. Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics 1994, 4:242-246.
18. Lavigne J.A., Goodman J.E., Fonong T., Odwin S., He P., Roberts D.W., Yager J.D. The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells. Cancer Research 2001, 61:7488-7494.
19. Lin P.H., Lin C.H., Huang C.C., Fang J.P., Chuang M.C. 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates the induction of DNA strand breaks and poly(ADP-ribose) polymerase-1 activation by 17beta-estradiol in human breast carcinoma cells through alteration of CYP1A1 and CYP1B1 expression. Chemical Research Toxicology 2008, 21:1337-1347.
20. Lin P.H., Nakamura J., Yamaguchi S., Asakura S., Swenberg J.A. Aldehydic DNA lesions induced by catechol estrogens in calf thymus DNA. Carcinogenesis 2003, 24:1133-1141.
21. Longnecker M.P., Klebanoff M.A., Brock J.W., Guo X. Maternal levels of polychlorinated biphenyls in relation to preterm and small-for-gestational-age birth. Epidemiology 2005, 16:641-647.
22. Luo C., Zou P., Ji G., Gu A., Zhao P., Zhao C. The aryl hydrocarbon receptor (AhR) 1661G>A polymorphism in human cancer. A meta-analysis. Gene 2013, 513:225-230.
23. Martucci C.P., Fishman J. P450 enzymes of estrogen metabolism. Pharmacology & Therapeutics 1993, 57:237-257.
24. Masuda Y. Fate of PCDF/PCB congeners and change of clinical symptoms in patients with Yusho PCB poisoning for 30 years. Chemosphere 2001, 43:925-930.
25. Matsueda T., Kajiwara J., Iwamoto S., Iida T., Izuno C., Yoshimura T. Analysis of residual nature of dioxins in blood of Yucho patients and controls in relation to the Yusho oil and food as respective exposure routes. Fukuoka Igaku Zasshi. Fukuoka Acta Medica 2007, 98:196-202. (in Japanese).
26. Mattsson R., Mattsson A., Kihlström J., Lindahl-Kiessling K. Effects of a hexachlorinated biphenyl on lymphoid organs and resorption of fetuses in pregnant mice. Archives of Environmental Contamination & Toxicology 1981, 10:281-288.
27. Miller K.P., Borgeest C., Greenfeld C., Tomic D., Flaws J.A. In utero effects of chemicals on reproductive tissues in female. Toxicology & Applied Pharmacology 2004, 198:111-131.
28. Mimura J., Fujii-Kuriyama Y. Functional role of AhR in the expression of toxic effects by TCDD. Biochimica et Biophysica Acta 2003, 1619:263-268.
29. Miura T., Muraoka S., Fujimoto Y., Zhao K. DNA strand break and 8-hydroxyguanine formation induced by 2-hydroxyestradiol dispersed in liposomes. Journal of Steroid Biochemistry & Molecular Biology 2000, 74:93-98.
30. Miyashita C., Sasaki S., Saijo Y., Washino N., Okada E., Kobayashi S., Konishi K., Kajiwara J., Todaka T., Kishi R. Effects of prenatal exposure to dioxin-like compounds on allergies and infections during pregnancy. Environment Research 2011, 111:551-558.
31. Nagayama K., Sasaki S., Matsushita A., Ohba K., Iwaki H., Matsunaga H., Suzuki S., Misawa H., Ishizuka K., Oki Y., Noh J.Y., Nakamura H. Inhibition of GATA2-dependent transactivation of the TSHbeta gene by ligand-bound estrogen receptor alpha. Journal of Endocrinology 2008, 199:113-125.
32. Nakajima S., Saijo Y., Kato S., Sasaki S., Uno A., Kanagami N., Hirokawa H., Hori T., Tobiishi K., Todaka T., Nakamura Y., Yanagiya S., Sengoku Y., Iida T., Sata F., Kishi R. Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environment Health Perspective 2006, 114:773-778.
33. Nishijo M., Tawara K., Nakagawa H., Honda R., Kido T., Nishijo H., Saito S. 2,3,7,8-tetrachlorodibenzo-p-dioxin in maternal breast milk and newborn head circumference. Journal of Exposure Science & Environmental Epidemiology 2008, 18:246-251.
34. Piedrafita B., Erceg S., Cauli O., Monfort P., Felipo V. Developmental exposure to polychlorinated biphenyls PCB153 or PCB126 impairs learning ability in young but not in adult rats. European Journal of Neuroscience 2008, 27:177-182.
35. Qiu L., Yao L., Mao C., Yu K., Zhan P., Chen B., Yuan H., Zhang J., Xue K., Hu X. Lack of association of CYP1A2-164 A/C polymorphism with breast cancer susceptibility: a meta-analysis involving 17,600 subjects. Breast Cancer Research & Treatment 2010, 122:521-525.
36. Ranade A., Chang M.S., Ting C.T., Pei D., Hsiao C.F., Olivier M., Pesich R., Hebert J., Chen Y.D., Dzau V.J., Curb D., Olshen R., Risch N., Cox D.R., Botstein D. High-throughput genotyping with single nucleotide polymorphisms. Genome Research 2001, 11:1262-1268.
37. Sánchez-Guerra M., Pelallo-Martínez N., Díaz-Barriga F., Rothenberg S.J., Hernández-Cadena L., Faugeron S., Oropeza-Hernández L.F., Guaderrama-Díaz M., Quintanilla-Vega B. Environmental polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage in Mexican children. Mutation Research 2012, 742:66-71.
38. Sasaki S., Kondo T., Sata F., Saijo Y., Katoh S., Nakajima S., Ishizuka M., Fujita S., Kishi R. Maternal smoking during pregnancy and genetic polymorphisms in the Ah receptor, CYP1A1 and GSTM1 affect infant birth size in Japanese subjects. Molecular Human Reproduction 2006, 12:77-83.
39. Sasaki S., Sata F., Katoh S., Saijo Y., Nakajima S., Washino N., Konishi K., Ban S., Ishizuka M., Kishi R. Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-nitrosoamine-metabolizing enzyme genes NQO1 and CYP2E1. American Journal of Epidemiology 2008, 167:719-726.
40. Seifert A., Taubert H., Hombach-Klonisch S., Fischer B., Navarrete Santos A. TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions. International Journal of Oncology 2009, 35:417-424.
41. Shimada N., Iwasaki M., Kasuga Y., Yokoyama S., Onuma H., Nishimura H., Kusama R., Hamada G.S., Nishimoto I.N., Iyeyasu H., Motola J., Laginha F.M., Kurahashi N., Tsugane S. Genetic polymorphisms in estrogen metabolism and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians. Journal of Human Genetology 2009, 54:209-215.
42. Shimada T., Gillam E.M., Sutter T.R., Strickland P.T., Guengerich F.P., Yamazaki H. Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Drug Metabolism & Disposition 1997, 25:617-622.
43. Singh A.P., Pant M.C., Ruwali M., Shah P.P., Prasad R., Mathur N., Parmar D. Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men. Cancer Biomarkers 2010, 8:351-359.
44. Skeaff S.A. Iodine deficiency in pregnancy: the effect on neurodevelopment in the child. Nutrients 2011, 3:265-273.
45. Song N., Tan W., Xing D., Lin D. CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China. Carcinogenesis 2001, 22:11-16.
46. Sonneborn D., Park H., Petrik J., Kocan A., Palkovicova A., Trnovec T., Nguyen D., Hertz-Picciotto I. Prenatal polychlorinated biphenyl exposures in eastern Slovakia modify effects of social factors on birthweight. Paediatr Perinat. Epidemiol. 2008, 22:202-213.
47. Spink D.C., Spink B.C., Cao J.Q., Gierthy J.F., Hayes C.L., Li Y., Sutter T.R. Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN human renal adenocarcinoma cells. Journal of Steroid Biochemistry & Molecular Biology 1997, 62:223-232.
48. Sram R.J., Binkova B., Dejmek J., Chvatalova I., Solansky I., Topinka J. Association of DNA adducts and genotypes with birth weight. Mutation Research 2006, 608:121-128.
49. Stejskalova L., Vecerova L., Mesa Peréz L., Vrzal R., Dvorak Z., Nachtigal P., Pavek P. Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures. Toxicological Science 2011, 123:26-36.
50. Su P.H., Huang P.C., Lin C.Y., Ying T.H., Chen J.Y., Wang S.L. The effect of in utero exposure to dioxins and polychlorinated biphenyls on reproductive development in eight year-old children. Environment International 2012, 39:181-187.
51. Sugimura H., Hamada G.S., Suzuki I., Iwase T., Kiyokawa E., Kino I., Tsugane S. CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil. Pharmacogenetics 1995, 5:S145-S148.
52. Tajimi M., Uehara R., Watanabe M., Oki I., Ojima T., Nakamura Y. Relationship of PCDD/F and Co-PCB concentrations in breast milk with infant birthweights in Tokyo, Japan. Chemosphere 2005, 61:383-388.
53. Todaka T., Hirakawa H., Tobiishi K., Iida T. New protocol of dioxins analysis in human blood. Fukuoka Acta Medica 2003, 41:197-204.
54. Tsuchiya M., Katoh T., Motoyama H., Sasaki H., Tsugane S., Ikenoue T. Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. Fertility & Sterility 2005, 84:454-458.
55. Tsukimori K., Uchi H., Mitoma C., Yasukawa F., Chiba T., Todaka T., Kajiwara J., Yoshimura T., Hirata T., Fukushima K., Wake N., Furue M. Maternal exposure of high levels of dioxins in relation to birth weight in women affected by Yusho disease. Environment International 2012, 38:79-86.
56. Van den Berg M., Birnbaum L., Bosveld A.T., Brunström B., Cook P., Feeley M., Giesy J.P., Hanberg A., Hasegawa R., Kennedy S.W., Kubiak T., Larsen J.C., van Leeuwen F.X., Liem A.K., Nolt C., Peterson R.E., Poellinger L., Safe S., Schrenk D., Tillitt D., Tysklind M., Younes M., Waern F., Zacharewski T. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environment Health Perspective 1998, 106:775-792.
57. Van den Berg M., Birnbaum L.S., Denison M., De Vito M., Farland W., Feeley M., Fieder H., Hakansson H., Hanberg A., Haws L., Rose M., Safe S., Schrenk D., Tohyama C., Tritscher A., Tuomisto J., Tysklind M., Walker N., Peterson R.E. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicological Science 2006, 93:223-241.
58. White S.S., Birnbarm L.S. An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology. Journal of Environmental Science and Health Part C: Environmental Carcinogenesis and Ecotoxicology Reviews 2009, 27:197-211.
59. Wormke M., Stoner M., Saville B., Walker K., Abdelrahim M., Burghardt R., Safe S. The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. Molecular & Cellular Biology 2003, 23:1843-1855.
60. Xie Y., Liu G., Miao X., Liu Y., Zhou W., Zhong D. CYP1B1 Leu432Val polymorphism and colorectal cancer risk among Caucasians: a meta-analysis. Tumor Biology 2012, 33:809-816.
61. Yila T.A., Sasaki S., Miyashita C., Braimoh T.S., Kashino I., Kobayashi S., Okada E., Baba T., Yoshioka E., Minakami H., Endo T., Sengoku K., Kishi R. Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and tobacco smoking on infant birth weight in a Japanese population. Journal of Epidemiology 2012, 22:91-102.
62. Yu L., Sun L., Jiang Y., Lu B., Sun D., Zhu L. Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies. Molecular Biology Reports 2012, 39:6641-6646.
63. Ziegler D.M. Bioactivation of xenobiotics by flavin-containing monooxygenases. Advances in Experimental Medicine &. Biology 1991, 283:41-50.