m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals

Aging and Disease

Volumn 2, Issue 4, 2011, Pages 301-307

  Cavarsan, Clarissa Fantin ^a   Avanzi, Renata Della Torre ^a   Queiroz, Claudio Marcos ^b   Xavier, Gilberto Fernando ^c   Mello, Luiz Eugênio ^a   Covolan, Luciene ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aging; Epilepsy; Hippocampus; m1 ACh receptor; Pilocarpine

Indexed keywords

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84877317712     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Eppinger B, Herbert M and Kray J (2010). We remember the good things: Age differences in learning and memory. Neurobiol Learn Mem, 93: 515-521
2. Gutchess A and Park D (2009). Effects of Aging on Associative Memory for Related and Unrelated Pictures. Eur J Cogn Psychol., 21: 235-254
3. Helmstaedter C and Elger C (1996). Cognitive consequences of two-thirds anterior temporal lobectomy on verbal memory in 144 patients: a three-month followup study. Epilepsia, 37: 171-180
4. Tuchscherer V, Seidenberg M, Pulsipher D, Lancaster M, Guidotti L and Hermann B (2010). Extrahippocampal integrity in temporal lobe epilepsy and cognition: thalamus and executive functioning. Epilepsy Behav, 17: 478-482
5. Pereira H, Benassi S and Mello L (2005). Plastic changes and disease-modifying effects of scopolamine in the pilocarpine model of epilepsy in rats. Epilepsia, 46: 118- 124
6. Drachman D and Leavitt J (1974). Human memory and the cholinergic system. A relationship to aging? Arch Neurol., 30: 113-121
7. Flicker C, Dean R, Bartus R, Ferris S and Crook T (1985). Animal and human memory dysfunctions associated with aging, cholinergic lesions, and senile dementia. Ann N Y Acad Sci, 444: 515-517
8. Bartus R (2000). On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol., 163: 495-529
9. Anagnostaras S, Murphy G, Hamilton S, Mitchell S, Rahnama N, Nathanson N and Silva A (2003). Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nat Neurosci., 6: 51-58
10. Miyakawa T, Yamada M, Duttaroy A and Wess J (2001). Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor. J Neurosci., 21: 5239-5250
11. Covolan L and Mello L (2006). Assessment of the progressive nature of cell damage in the pilocarpine model of epilepsy. Braz J Med Biol Res., 39: 915-924
12. Covolan L, Smith R and Mello L (2000). Ultrastructural identification of dentate granule cell death from pilocarpine-induced seizures. Epilepsy Res, 41: 9-21
13. Mello L, Cavalheiro E, Tan A, Kupfer W, Pretorius J, Babb T and Finch D (1993). Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia, 34: 985-995
14. Racine R (1972). Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol., 32: 281-294
15. Morris R, Garrud P, Rawlins J and O'Keefe J (1982). Place navigation impaired in rats with hippocampal lesions. Nature, 297: 681-683
16. Avanzi R, Cavarsan C, Santos Jr J, Hamani C, Mello L and Covolan L (2010). Basal dendrites are present in newly born dentate granule cells of young but not aged pilocarpine-treated chronic epileptic rats. Neuroscience, 170: 687-691
17. Lehmann T, Gabriel S, Kovacs R, Eilers A, Kivi A, Schulze K, Lanksch W, Meencke H and Heinemann U (2000). Alterations of neuronal connectivity in area CA1 of hippocampal slices from temporal lobe epilepsy patients and from pilocarpine-treated epileptic rats. Epilepsia, 41: S190-194
18. Mello L and Covolan L (1996). Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures. Epilepsy Res., 26: 123-129
19. Balakrishnan S, Mathew J and Paulose C (2010). Cholinergic and glutamergic receptor functional regulation in long-term, low dose somatotropin and insulin treatment to ageing rats: rejuvenation of brain function. Mol Cell Endocrinol., 314: 23-30
20. Kremin T, Gerber D, Giocomo L, Huang S, Tonegawa S and Hasselmo M (2006). Muscarinic suppression in stratum radiatum of CA1 shows dependence on presynaptic M1 receptors and is not dependent on effects at GABA(B) receptors. Neurobiol Learn Mem., 85: 153- 163
21. Levey A, Edmunds S, Koliatsos V, Wiley R and Heilman C (1995). Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation. J Neurosci., 15: 4077-4092
22. Frotscher M and Léránth C (1985). Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: a combined light and electron microscopic study. J Comp Neurol., 239: 237-246
23. Harvey J, Balasubramaniam R and Collingridge G (1993). Carbachol can potentiate N-methyl-D-aspartate responses in the rat hippocampus by a staurosporine and thapsigargin-insensitive mechanism. Neurosci Lett., 162: 165-168
24. Fernández de Sevilla D, Núñez A, Borde M, Malinow R and Buño W (2008). Cholinergic-mediated IP3-receptor activation induces long-lasting synaptic enhancement in CA1 pyramidal neurons. J Neurosci., 28: 1469-1478
25. Fernández de Sevilla D and Buño W (2010). The muscarinic long-term enhancement of NMDA and AMPA receptor-mediated transmission at Schaffer collateral synapses develop through different intracellular mechanisms. J Neurosci., 30: 11032-11042
26. Covolan L, Urini A, Avanzi R, Cavarsan C, Santos Jr J and Mello L (2009) Cholinergic inputs to hippocampus is reduced in aged animals after pilocarpine-induced seizures. In Society for Neuroscience Meeting p. 17572, Chicago
27. Tayebati S, Amenta F, El-Assouad D and Zaccheo D (2002). Muscarinic cholinergic receptor subtypes in the hippocampus of aged rats. Mech Ageing Dev., 123: 521- 528
28. Tandon P, Mundy W, Ali S, Nanry K, Rogers B and Tilson H (1991). Age-dependent changes in receptorstimulated phosphoinositide turnover in the rat hippocampus. Pharmacol Biochem Behav., 38: 861-867