The efficacy of strontium and potassium toothpastes in treating dentine hypersensitivity: A systematic review

International Journal of Dentistry

Volumn 2013, Issue , 2013, Pages

  Karim, B F A ^a   Gillam, D G ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84877313393     PISSN: 16878728     EISSN: 16878736     Source Type: Journal    
DOI: 10.1155/2013/573258     Document Type: Review

References (116)

1. Canadian Advisory Board on Dentin Hypersensitivity, Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. Journal of the Canadian Dental Association 2003 69 4 221 226
2. Gillam D. G., Current diagnosis of dentin hypersensitivity in the dental office: an overview. Clinical Oral Investigations 2013 10. 1007/s00784-012-0911- 1
3. Orchardson R., Gillam D. G., Managing dentin hypersensitivity. Journal of the American Dental Association 2006 137 7 990 998 2-s2.0-33746596635 (Pubitemid 44153900)
4. Gillam D. G., Newman H. N., Assessment of pain in cervical dentinal sensitivity studies. A review. Journal of Clinical Periodontology 1993 20 6 383 394 2-s2.0-0027636573
5. Holland G. R., Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Journal of Clinical Periodontology 1997 24 11 808 813 2-s2.0-0031263945 (Pubitemid 127731629)
6. ADA Acceptance Program Guidelines-Products for the Treatment of Dentinal Hypersensitivity. 2009, http://www.docstoc.com/docs/ 2976618/ Acceptance-Program-Guidelines-Products-for-the-Treatment-of-Dentinal- Hypersensitivity
7. Jackson R. J., Addy M., Embery G., Edgar W. M., Orchardson R., Potential treatment modalities for dentine hypersensitivity: home use products. Tooth Wear and Sensitivity 2000 London, UK Martin Dunitz 328 338
8. Orchardson R., Gillam D. G., The efficacy of potassium salts as agents for treating dentin hypersensitivity. Journal of Orofacial Pain 2000 14 1 9 19 2-s2.0-0034569405
9. Poulsen S., Errboe M., Lescay Mevil Y., Glenny A. M., Potassium containing toothpastes for dentine hypersensitivity. The Cochrane Library 2008 no. 4
10. Cummins D., Dentin hypersensitivity: from diagnosis to a breakthrough therapy for everyday sensitivity relief. Journal of Clinical Dentistry 2009 20 1 1 9 2-s2.0-67650215339
11. Cummins D., Recent advances in dentin hypersensitivity: clinically proven treatments for instant and lasting sensitivity relief. American Journal of Dentistry 2010 23 3A 13A 2-s2.0-78650531871
12. Greenspan D. C., NovaMinand tooth sensitivity-an overview. Journal of Clinical Dentistry 2010 21 3 61 65 2-s2.0-78751518438
13. Hsui Y., The prevalence of root sensitivity following periodontal therapy: a systematic review [MClinDent Thesis] 2010 London, UK
14. Higgins J. P. T., Green S.,. Cochrane Handbook for Systematic Reviews of Intervention 4. 2. 6, 2006
15. Addy M., Mostafa P., Newcombe R., Dentine hypersensitivity: a comparison of five toothpastes used during a 6-week treatment period. British Dental Journal 1987 163 2 45 51 2-s2.0-0023664663
16. Blitzer B., A consideration of the possible causes of dental hypersensitivity: treatment by a strontium-ion dentifrice. Periodontics 1967 5 6 318 321 2-s2.0-0014151563
17. Carrasco H. P., Strontium chloride toothpaste-effectiveness as related to duration of use. Pharmacology and Therapeutics in Dentistry 1971 1 4 209 215 2-s2.0-0015070218
18. Dabsie F., Gregoire G., Sixou M., Sharrock P., Does strontium play a role in the cariostatic activity of glass ionomer?. Strontium diffusion and antibacterial activity. Journal of Dentistry 2009 37 7 554 559 2-s2.0-65549151923 10.1016/j.jdent.2009.03.013
19. Earl J. S., Ward M. B., Langford R. M., Investigation of dentinal tubule occlusion using FIB-SEM milling and EDX. Journal of Clinical Dentistry 2010 21 2 37 41 2-s2.0-77955903693
20. Gedalia I., Almog D., Yariv S., Effects of strontium and fluoride uptakes on the solubility of powdered enamel. Caries Research 1977 11 5 287 292 2-s2.0-0017414288 (Pubitemid 8129848)
21. Gedalia I., Brayer L., Kalter N., The effect of fluoride and strontium application on dentin: in vivo and in vitro studies. Journal of Periodontology 1978 49 5 269 272 2-s2.0-0017816781 (Pubitemid 8358386)
22. Gillam D. G., Newman H. N., Davies E. H., Bulman J. S., Clinical efficacy of a low abrasive dentifrice for the relief of cervical dentinal hypersensitivity. Journal of Clinical Periodontology 1992 19 3 197 201 2-s2.0-0026560010
23. Gillam D. G., Newman H. N., Bulman J. S., Davies E. H., Dentifrice abrasivity and cervical dentinal hypersensitivity. Results 12 weeks following cessation of 8 weeks' supervised use. Journal of Periodontology 1992 63 1 7 12 2-s2.0-0026494140
24. Goldie M. P., Potassium nitrate, sodium fluoride, strontium chloride, and NovaMin technologies for dentin hypersensitivity. Minimal Intervention Dentistry 2011 5 4
25. Gutentag H., The effect of strontium chloride on peripheral nerve in comparison to the action of "stabilizer" and "labilizer" compounds. The Penn Dental Journal 1965 68 2 37 43 2-s2.0-0141634777
26. Hughes N., Mason S., Jeffery P., Welten H., Tobin M., O'Shea C., Browne M., A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. Journal of Clinical Dentistry 2010 21 2 49 55 2-s2.0-77955870209
27. Kanapka J. A., Over-the-counter dentifrices in the treatment of tooth hypersensitivity. Review of clinical studies. Dental Clinics of North America 1990 34 3 545 560 2-s2.0-0025454252
28. Kishore A., Mehrotra K. K., Saimbi C. S., Effectiveness of desensitizing agents. Journal of Endodontics 2002 28 1 34 35 2-s2.0-0036365752
29. Kobler A., Kuß O., Schaller H. G., Gernhardt C. R., Clinical effectiveness of a strontium chloride-containing desensitizing agent over 6 months: a randomized, double-blind, placebo-controlled study. Quintessence International 2008 39 4 321 325 2-s2.0-40649101896
30. Markowitz K., The original desensitizers: strontium and potassium salts. Journal of Clinical Dentistry 2009 20 5 145 151 2-s2.0-70449480608
31. Mason S., Hughes N., Sufi F., Bannon L., Maggio B., North M., Holt J., A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. Journal of Clinical Dentistry 2010 21 2 42 48 2-s2.0-77955904045
32. Parkinson C. R., Butler A., Willson R. J., Development of an acid challenge-based in vitro dentin disc occlusion model. Journal of Clinical Dentistry 2010 21 2 31 36 2-s2.0-77955911887
33. Pearce N. X., Addy M., Newcombe R. G., Dentine hypersensitivity: a clinical trial to compare 2 strontium densensitizing toothpastes with a conventional fluoride toothpaste. Journal of Periodontology 1994 65 2 113 119 2-s2.0-0028380874
34. Pol D. G., Jonnala J., Chute M., Gunjikar T., Pol S., Desensitising agents, "what is more preferable.dentifrice or mouthwash?" Journal of the Indian Dental Association 2010 4 22 486 487
35. Ross M. R., Hypersensitive teeth: effect of strontium chloride in a compatible dentifrice. Journal of Periodontology 1961 32 49 53
36. Shapiro W. B., Kaslick R. S., Chasens A. I., The effect of a strontiumhloridetoothpaste on root hypersensitivity in a controlled clinical study. Journal of Periodontology 1970 41 12 702 703 2-s2.0-0014888908
37. Shapiro W. B., Kaslick R. S., Chasens A. I., Weinstein D., Controlled clinical comparison between a strontium chloride and a sodium monofluorophosphate toothpaste in diminishing root hypersensitivity. Journal of Periodontology 1970 41 9 523 525 2-s2.0-0014848763
38. Stazen P. J., Foreman D. W., Diffusion of strontium from desensitizing agents into human dentin as determined by energy-dispersive analysis. Journal of Dental Research 1977 56 1 28 35 2-s2.0-0017445267
39. Surdacka A., Stopa J., Torlinski L., In situ effect of strontium toothpaste on artificially decalcified human enamel. Biological Trace Element Research 2007 116 2 147 153 2-s2.0-34547567091 10.1007/s12011-007-9024-0 (Pubitemid 47196786)
40. Tarbet W. J., Silverman G., Fratarcangelo P. A., Kanapka J. A., Home treatment for dentinal hypersensitivity: a comparative study. The Journal of the American Dental Association 1982 105 2 227 230 2-s2.0-0020170310
41. Uchida A., Wakano Y., Fukuyama O., Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery. Journal of Periodontology 1980 51 10 578 581 2-s2.0-0019157489 (Pubitemid 11211084)
42. West N. X., Dentine hypersensitivity and the placebo response A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastes. Journal of Clinical Periodontology 1997 24 4 209 215 2-s2.0-0031113548 (Pubitemid 127731516)
43. West N. X., Addy M., Jackson R. J., Ridge D. B., Comparison of strontium acetate and potassium nitrate dentifrices on dentine hypersensitivity. Journal of Dental Research 1996 75 1150, Abstract no. 161
44. Collins J. F., Perkins L., Clinical evaluation of the effectiveness of three dentifrices in relieving dentin sensitivity. Journal of Periodontology 1984 55 12 720 725 2-s2.0-0021668191
45. Kumar R. V., Shubhashini N., Sheshan H., Kranti K., A clinical trial comparing a stannous fluoride based dentifrice and a strontium chloride based dentifrice in alleviating dentinal hypersensitivity. Journal of International Oral Heath 2010 2 37 50
46. Ajcharanukul O., Kraivaphan P., Wanachantararak S., Vongsavan N., Matthews B., Effects of potassium ions on dentine sensitivity in man. Archives of Oral Biology 2007 52 7 632 639 2-s2.0-34247862176 10.1016/j.archoralbio.2006. 12.015 (Pubitemid 46695847)
47. Andreana S., Zanna S., De Carlo B., Pitzolu G., Sauro S., Piana G., Mongiorgi R., Dentin permeability after Zinc-carbonate-hydroxyapatite paste treatment: in vitro evaluation. Journal of Dental Research 2009 87 Abstract no. 1887
48. Aris A., Gillam D., Newman H. N., Ley F., Swern A., Friedman M., Curro F., Assessment of the tactile response in an 8 week hypersensitivity study. Journal of Dental Research 2000 79 576, Abstract no. 3459
49. Ayad F., Ayad N., Zhang Y. P., DeVizio W., Cummins D., Mateo L. R., Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian adults. Journal of Clinical Dentistry 2009 20 1 10 16 2-s2.0-67650242375
50. Ayad F., Berta R., De Vizio W., McCool J., Petrone M. E., Volpe A. R., Comparative efficacy of two dentifrices containing 5% potassium nitrate on dentinal sensitivity: a twelve-week clinical study. Journal of Clinical Dentistry 1994 5 97 101 2-s2.0-0028649523
51. Bohen F., Lafont J., Dentinal hypersensitivity: clinical evaluation about the efficiency of a new desensitization agent. http://www.septodontusa.com/ sites/default/files/Isodan-2.pdf
52. Browning W. D., Chan D. C. N., Frazier K. B., Callan R. S., Blalock J. S., Safety and efficacy of a nightguard bleaching agent containing sodium fluoride and potassium nitrate. Quintessence International 2004 35 9 693 698 2-s2.0-4544234103 (Pubitemid 39233417)
53. Charig A. J., Xu Y., Thong S., Winston A. E., Comparison of mechanism of action of desensitizing treatments. Journal of Dental Research 2008 86 Abstract no. 3160
54. Conforti N., Battista G. W., Petrone D. M., Petrone M. E., Chaknis P., Zhang Y. P., DeVizio W., Volpe A. R., Proskin H. M., Comparative investigation of the desensitizing efficacy of a new dentifrice: a 14-day clinical study. Compendium of Continuing Education in Dentistry 2000 27 17 28 2-s2.0-0034584531
55. Cooley R. L., Sandoval V. A., Effectiveness of potassium oxalate treatment on dentin hypersensitivity. General Dentistry 1989 37 4 330 333 2-s2.0-0024692212
56. Docimo R., Montesani L., Maturo P., Costacurta M., Bartolino M., DeVizio W., Zhang Y. P., Cummins D., Dibart S., Mateo L. R., Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy. Journal of Clinical Dentistry 2009 20 1 17 22 2-s2.0-67650248903
57. Frechoso S. C., Menéndez M., Guisasola C., Arregui I., Tejerina J. M., Sicilia A., Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial. Journal of Clinical Periodontology 2003 30 4 315 320 2-s2.0-0038488755 10.1034/j.1600-051X.2003.20077.x (Pubitemid 38019391)
58. Gillam D. G., Bulman J. S., Jackson R. J., Newman H. N., Efficacy of a potassium nitrate mouthwash in alleviating cervical dentine sensitivity (CDS). Journal of Clinical Periodontology 1996 23 11 993 997 2-s2.0-0030277573 (Pubitemid 126732070)
59. Gillam D. G., Bulman J. S., Jackson R. J., Newman H. N., Comparison of 2 desensitizing dentifrices with a commercially available fluoride dentifrice in alleviating cervical dentine sensitivity. Journal of Periodontology 1996 67 8 737 742 2-s2.0-0030203194 (Pubitemid 126569943)
60. Goncalves A. C. K., Pinto S. C. S., Silveira C. M. M., Pochapski M. T., Wambier D. S., Pilatti G. L., Santos F. A., Effects of desensitizing toothpastes on dentin permeability: an animal study. Journal of Dental Research 2011 89 Abstract no. 1309
61. Hall P. J., Horay C. P., Spradbery P. S., Hill D., Barlow A. P., Intra-oral potassium dispersion profile of a gel to foam toothpaste. Journal of Dental Research 2008 86 Abstract no. 0466
62. Van Haywood B., Frank Caughman W., Frazier K. B., Myers M. L., Tray delivery of potassium nitrate-fluoride to reduce bleaching sensitivity. Quintessence International 2001 32 2 105 109 2-s2.0-0035248640 (Pubitemid 33713992)
63. Haywood V. B., Cordero R., Wright K., Gendreau L., Rupp R., Kotler M., Littlejohn S., Fabyanski J., Smith S., Brushing with a potassium nitrate dentifrice to reduce bleaching sensitivity. Journal of Clinical Dentistry 2005 16 1 17 22 2-s2.0-19044383134 (Pubitemid 40712439)
64. Hodosh M., A superior desensitizer-potassium nitrate. The Journal of the American Dental Association 1974 88 4 831 832 2-s2.0-0016053024
65. Hodosh M., Current treatment for dentinal hypersensitivity. Potassium nitrate as a desensitizer. The Compendium of Continuing Education in Dentistry 1982 3 S120 121 2-s2.0-0020430942
66. Jalalian E., Meraji N., Mirzaei M., A comparison of the efficacy of potassium nitrate and gluma desensitizer in the reduction of hypersensitivity in teeth with full-crown preparations. Journal of Contemporary Dental Practice 2009 10 1 66 73 2-s2.0-58649092403
67. Kawamata H., Ohta K., Saito T., Hayman R., Potassium nitrate enhances occlusion of dentinal tubules by nano-hydroxyapatite. Journal of Dental Research 2008 86 Abstract no. 2265
68. Lecointre C., Apiou J., Marty P., Poitou P., Controlled trial of the action of a toothpaste containing nicomethanol hydrofluoride in the treatment of dentine hypersensitivity. Journal of International Medical Research 1986 14 4 217 222 2-s2.0-0022482113 (Pubitemid 16036552)
69. Manochehr-Pour M., Bhat M., Bissada N., Clinical evaluation of two potassium nitrate toothpastes for the treatment of dental hypersensitivity. Periodontal Case Reports 1984 6 1 25 30 2-s2.0-0021118807
70. McCormack K., Davies R., The enigma of potassium ion in the management of dentine hypersensitivity: is nitric oxide the elusive second messenger? Pain 1996 68 1 5 11 2-s2.0-0030275502 10.1016/S0304-3959(96)03142-9 (Pubitemid 126407750)
71. Mordan N. J., Gillam D. G., Bock N. J., Ley F., Curro F. A., ESEM vs. SEM evaluation of desensitising dental products on dentine. Journal of Dental Research 2002 81 Special Issue A, A-373, Abstract no. 3001
72. Morris A., Gallob J., Amini P., Santos S., Qaquish J., Peng P., McGuire J., Efficacy of a potassium nitrate mouthrinse for relieving dentinal hypersensitivity. Journal of Dental Research 2009 87 Abstract no. 1575
73. Pamir T., Özyazici M., Balolu E., Önal B., The efficacy of three desensitizing agents in treatment of dentine hypersensitivity. Journal of Clinical Pharmacy and Therapeutics 2005 30 1 73 76 2-s2.0-23844509593 10.1111/j.1365-2710.2004.00613.x (Pubitemid 41602094)
74. Peacock J. M., Orchardson R., Effects of potassium ions on action potential conduction in A- and C-fibers of rat spinal nerves. Journal of Dental Research 1995 74 2 634 641 2-s2.0-0029246955
75. Peacock J. M., Orchardson R., Action potential conduction block of nerves in vitro by potassium citrate, potassium tartrate and potassium oxalate. Journal of Clinical Periodontology 1999 26 1 33 37 2-s2.0-0032615692
76. Pereira J. C., Segala A. D., Gillam D. G., Effect of desensitizing agents on the hydraulic conductance of human dentin subjected to different surface pre-treatments-an in vitro study. Dental Materials 2005 21 2 129 138 2-s2.0-12344279964 10.1016/j.dental.2004.02.007 (Pubitemid 40135740)
77. Pillon F. D., Romani I. G., Schmidt É. R., Effect of a 3% potassium oxalate topical application on dentinal hypersensitivity after subgingival scaling and root planing. Journal of Periodontology 2004 75 11 1461 1464 2-s2.0-10944226484 10.1902/jop.2004.75.11.1461 (Pubitemid 40012328)
78. Pol D. G., Jonnala J., Chute M., Gunjikar T., Pol S., Potassium nitrate in the treatment of dentinal hypersensitivity-a mini analysis of studies. Journal of the Indian Dental Association 2010 4 399 403
79. Prasad K. V. V., Sohoni R., Tikare S., Yalamalli M., Rajesh G., Javali S. B., Efficacy of two commercially available dentifrices in reducing dentinal hypersensitivity. Indian Journal of Dental Research 2010 21 2 224 230 2-s2.0-78049360487 10.4103/0970-9290.66639
80. Reinhart T. C., Killoy W. J., Love J., Overman P. R., Sakumura J. S., The effectiveness of a patient-applied tooth desensitizing gel. A pilot study. Journal of Clinical Periodontology 1990 17 2 123 127 2-s2.0-0025008727 (Pubitemid 20078168)
81. Salian S., Thakur S., Kulkarni S., Latorre G., A randomized controlled clinical study evaluating the efficacy of two desensitizing dentifrices. Journal of Clinical Dentistry 2010 21 3 82 87 2-s2.0-78751511846
82. Salvato A. R., Clark G. E., Gingold J., Curro F. A., Clinical effectiveness of a dentifrice containing potassium chloride as a desensitizing agent. American Journal of Dentistry 1992 5 6 303 306 2-s2.0-0027025043
83. Sharma N., A randomized, parallel group clinical study evaluating the efficacy of three desensitizing dentifrices. 2010. http://www.oralscience.ca/fr/ documentation/education/A-Randomized-Parallel-Group-Clinical-Study-Evaluating- the-Efficacy-of-three-Desensitizing-Dentifrices.pdf
84. Sharma N., Roy S., Kakar A., Greenspan D. C., Scott R., A clinical study comparing oral formulations containing 7.5% calcium sodium phosphosilicate (novamin), 5% potassium nitrate, and 0.4% stannous fluoride for the management of dentin hypersensitivity. Journal of Clinical Dentistry 2010 21 3 88 92 2-s2.0-78751505042
85. Silverman G., The sensitivity-reducing effect of brushing with a potassium nitrate-sodium monofluorophosphate dentifrice. The Compendium of Continuing Education in Dentistry 1985 6 2 131 136 2-s2.0-0022018701
86. Silverman G., Gingold J., Curro F. A., Desensitizing effect of a potassium chloride dentifrice. American Journal of Dentistry 1994 7 1 9 12 2-s2.0-0028382152
87. Sowinski J. A., Bonta Y., Battista G. W., Petrone D., DeVizio W., Petrone M., Proskin H. M., Desensitizing efficacy of colgate sensitive maximum strength and fresh mint sensodyne dentifrices. American Journal of Dentistry 2000 13 3 116 120 2-s2.0-0034209249
88. Sowinski J., Ayad F., Petrone M., DeVizio W., Volpe A., Ellwood R., Davies R., Comparative investigations of the desensitising efficacy of a new dentifrice. Journal of Clinical Periodontology 2001 28 11 1032 1036 2-s2.0-0035515537 (Pubitemid 33757266)
89. Stead W. J., Orchardson R., Warren P. B., A mathematical model of potassium ion diffusion in dentinal tubules. Archives of Oral Biology 1996 41 7 679 687 2-s2.0-0030186775 10.1016/S0003-9969(96)00073-8 (Pubitemid 27089666)
90. Tarbet W. J., Silverman G., Stolman J. M., Fratarcangelo P. A., Clinical evaluation of a new treatment for dentinal hypersensitivity. Journal of Periodontology 1980 51 9 535 540 2-s2.0-0019149858 (Pubitemid 11255718)
91. Tarbet W. J., Buckner A., Stark M. M., The pulpal effects of brushing with a 5 percent potassium nitrate paste used for desensitization. Oral Surgery Oral Medicine and Oral Pathology 1981 51 6 600 602 2-s2.0-0019515058 (Pubitemid 11089002)
92. Touyz L. Z., Stern J., Hypersensitive dentinal pain attenuation with potassium nitrate. General Dentistry 1999 47 1 42 45 2-s2.0-0032609124
93. Wang W. J., Rong W. S., Liang Y., Desensitizing effect of a toothpaste containing potassium citrate. Journal of Dental Research 2010 87 Abstract no. 2555
94. Wara-aswapati N., Krongnawakul D., Jiraviboon D., Adulyanon S., Karimbux N., Pitiphat W., The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health, plaque formation and dentine hypersensitivity. Journal of Clinical Periodontology 2005 32 1 53 58 2-s2.0-13244259352 10.1111/j.1600-051X.2004.00631.x (Pubitemid 40187426)
95. Yates R., West N. X., Addy M., Marlow I., The effects of a potassium citrate, cetylpyridinium chloride, sodium fluoride mouthrinse on dentine hypersensitivity, plaque and gingivitis. A placebo-controlled study. Journal of Clinical Periodontology 1998 25 10 813 820 2-s2.0-0032184990 (Pubitemid 128705985)
96. Yates R., Ferro R., Newcombe R. G., Addy M., A comparison of a reformulated potassium citrate desensitising toothpaste with the original proprietary product. Journal of Dentistry 2005 33 1 19 25 2-s2.0-11844288282 10.1016/j.jdent.2004.07.004 (Pubitemid 40093558)
97. Orsini G., Procaccini M., Manzoli L., Giuliodori F., Lorenzini A., Putignano A., A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice. Journal of Clinical Periodontology 2010 37 6 510 517 2-s2.0-77952342802 10.1111/j.1600-051X.2010.01558.x
98. Pradeep A. R., Sharma A., Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial. Journal of Periodontology 2010 81 8 1167 1173 2-s2.0-77955345212 10.1902/jop.2010.100056
99. Minkoff S., Axelrod S., Efficacy of strontium chloride in dental hypersensitivity. Journal of Periodontology 1987 58 7 470 474 2-s2.0-0023627478 (Pubitemid 17143421)
100. Nagata T., Ishida H., Shinohara H., Nishikawa S., Kasahara S., Wakano Y., Daigen S., Troullos E. S., Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity. Journal of Clinical Periodontology 1994 21 3 217 221 2-s2.0-0028400050
101. Schiff T., Dotson M., Cohen S., De Vizio W., McCool J., Volpe A., Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. Journal of Clinical Dentistry 1994 5 87 92 2-s2.0-0028618879
102. Schiff T., Dos Santos M., Laffi S., Yoshioka M., Baines E., Do Brasil K., McCool J. J., De Vizio W., Efficacy of a dentifrice containing 5% potassium nitrate and 1500 PPM sodium monofluorophosphate in a precipitated calcium carbonate base on dentinal hypersensitivity. Journal of Clinical Dentistry 1998 9 1 22 25 2-s2.0-0031987165 (Pubitemid 128505872)
103. Schiff T., Zhang Y. P., DeVizio W., Stewart B., Chaknis P., Petrone M. E., Volpe A. R., Proskin H. M., A randomized clinical trial of the desensitizing efficacy of three dentifrices. Compendium of Continuing Education in Dentistry 2000 27 4 28 2-s2.0-0034584848
104. Silverman G., Berman E., Hanna C. B., Salvato A., Fratarcangelo P., Bartizek R. D., Bollmer B. W., Campbell S. L., Lanzalaco A. C., Mackay B. J., Mcclanahan S. F., Perlich M. A., Shaffer J. B., Assessing the efficacy of three dentifrices in the treatment of dentinal hypersensitivity. Journal of the American Dental Association 1996 127 2 191 201 2-s2.0-0030076073 (Pubitemid 126432984)
105. Sowinski J. A., Battista G. W., Petrone M. E., Chaknis P., Zhang Y. P., DeVizio W., Volpe A. R., Proskin H. M., A new desensitizing dentifrice-an 8-week clinical investigation. Compendium of Continuing Education in Dentistry 2000 27 11 28 2-s2.0-0034584297
106. Tarbet W. J., Silverman G., Stolman J. M., Fratarcangelo P. A., An evaluation of two methods for the quantitation of dentinal hypersensitivity. The Journal of the American Dental Association 1979 98 6 914 918 2-s2.0-0018484338
107. Schulz K. F., Assessing allocation concealment and blinding in randomised controlled trials: why bother? Evidence-Based Mental Health 2000 3 1 4 5 2-s2.0-15944365823 10.1136/ebmh.3.1.4
108. Bowers D., Testing hypotheses about the difference between two population parameters. Medical Statistics from Scratch: An Introduction for Health Professionals 2008 chapter 12 London, UK John Wiley & Sons 141 145
109. Bowers D., Doing it right first time-designing a study. Medical Statistics from Scratch: An Introduction for Health Professionals 2008 chapter 6 London, UK John Wiley & Sons 71 90
110. Gillam D., Making sense of dentine hypersensitivity. Dental Practice 2009 47 10 12
111. Gillam D. G., Diagnosis and management of dentine hypersensitivity. Dental Tribune 2009 10 7 11 12
112. Gillam D. G., Management of dentine hypersensitivity: a guide to treatment options. Oral Health Report 2010 3 8 12
113. Zappa U., Self-applied treatments in the management of dentine hypersensitivity. Archives of Oral Biology 1994 39 1 S107 S112 2-s2.0-0028708047 10.1016/0003-9969(94)90196-1 (Pubitemid 124007939)
114. Addy M., Mostafa P., Dentine hypersensitivity. II. Effects produced by the uptake in vitro of toothpastes onto dentine. Journal of Oral Rehabilitation 1989 16 1 35 48 2-s2.0-0024387976
115. Ide M., Wilson R. F., Ashley F. P., The reproducibility of methods of assessment for cervical dentine hypersensitivity. Journal of Clinical Periodontology 2001 28 1 16 22 2-s2.0-0035219304 (Pubitemid 33755228)
116. Curro F. A., Friedman M., Leight R. S., Addy M., Embery G., Edgar W. M., Orchardson R., Design and conduct of clinical trials on dentine hypersensitivity. Tooth Wear and Sensitivity 2000 London, UK Martin Dunitz 299 314