Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction

Pharmacognosy Research

Volumn 5, Issue 2, 2013, Pages 71-79

  Chandrasekaran, Chinampudur ^a   Sundarajan, Kannan ^a   Edwin, Jothie ^a   Gururaja, Giligar ^a   Mundkinajeddu, Deepak ^a   Agarwal, Amit ^a  

^a Natural Remedies Pvt Ltd Bengaluru   (India)

Author keywords

Curcuma longa; immunomodulation; inflammation; pain; polysaccharides; Turmacin

Indexed keywords

ANTIINFLAMMATORY AGENT; CONCANAVALIN A; CURCUMA LONGA EXTRACT; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; POLYSACCHARIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; TURMACIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD LEVEL; CELL COUNT; CELL LINE; CELL PROLIFERATION; CURCUMA LONGA; CYTOKINE RELEASE; IMMUNOMODULATION; IMMUNOSTIMULATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; SPLEEN CELL;

EID: 84877307756     PISSN: None     EISSN: 09748490     Source Type: Journal    
DOI: 10.4103/0974-8490.110527     Document Type: Article

References (38)

1. Khanna NM. Turmeric, Nature's precious gift. Curr Sci 1999;76:1351-6.
2. Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane). J Biol Chem 1995;270:24995-5000.
3. Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S, et al. Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene 1999;18:6013-20. (Pubitemid 29535013)
4. Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol 2006;69:195-206. (Pubitemid 43048906)
5. Bhaumik S, Jyothi MD, Khar A. Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells. FEBS Lett 2000;483:78-82.
6. Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM. Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile. J Surg Res 2000;89:169-75. (Pubitemid 30196521)
7. Jagetia GC, Aggarwal BB. Spicing up of the immune system by curcumin. J Clin Immunol 2007;27:19-35.
8. He XG, Lin LZ, Lian LZ, Lindenmaier M. Liquid chromatographyelectrospray mass spectrometric analysis of curcuminoids and sesquiterpenoids in turmeric (Curcuma longa). J Chromatogr 1998;818:127-32. (Pubitemid 28401441)
9. Yue GG, Chan BC, Hon PM, Kennelly EJ, Yeung SK, Cassileth BR, et al. Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa. Int J Biol Macromol 2010;47:342-7.
10. Gonda R, Tomoda M, Shimizu N, Kanari M. Characterization of polysaccharides having activity on the reticuloendothelial system from the rhizome of Curcuma longa. Chem Pharm Bull (Tokyo) 1990;38:482-6. (Pubitemid 20161722)
11. Gonda R, Takeda K, Shimizu N, Tomoda M. Characterization of a neutral polysaccharide having activity on the reticuloendothelial system from the rhizome of Curcuma longa. Chem Pharm Bull (Tokyo) 1992;40:185-8.
12. Gonda R, Tomoda M, Takada K, Ohara N, Shimizu N. The core structure of ukonan A, a phagocytosis-Activating polysaccharide from the rhizome of Curcuma longa, and immunological activities of degradation products. Chem Pharm Bull (Tokyo) 1992;40:990-3.
13. Gonda R, Tomoda M, Ohara N, Takada K. Arabinogalactan core structure and immunological activities of ukonan C, an acidic polysaccharide from the rhizome of Curcuma longa. Biol Pharm Bull 1993;16:235-8. (Pubitemid 23142892)
14. Tomoda M, Gonda R, Shimizu N, Kanari M, Kimura M. A reticuloendothelial system activating glycan from the rhizomes of Curcuma longa. Phytochemistry 1990;29:1083-6.
15. Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 2002;60:258-74.
16. Jeon YJ, Kim HM. Experimental evidences and signal transduction pathways involved in the activation of NF-kappa B/Rel by angelan in murine macrophages. Int Immunopharmacol 2001;1:1331-9. (Pubitemid 32522986)
17. Yoon YD, Kang JS, Han SB, Park SK, Lee HS, Kang JS, et al. Activation of mitogen-Activated protein kinases and AP-1 by polysaccharide isolated from the radix of Platycodon grandiflorum in RAW 264.7 cells. Int Immunopharmacol 2004;4:1477-87. (Pubitemid 39200597)
18. Ramberg JE, Nelson ED, Sinnott RA. Immunomodulatory dietary polysaccharides: A systematic review of the literature. Nutr J 2010;9:54.
19. Trnovec T, Hrmová M. Immunomodulator polysaccharides: Chemistry, disposition and metabolism. Biopharm Drug Dispos 1993;14:187-98. (Pubitemid 23100000)
20. Mohankumar S, McFarlane Jr. An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro. Phytother Res 2011;25:396-401.
21. Deshpande SS, Ingle AD, Maru GB. Chemopreventive efficacy of curcumin-free aqueous turmeric extract in 7,12-dimethylbenz a anthracene-induced rat mammary tumorigenesis. Cancer Lett 1998;123:35-40. (Pubitemid 28046206)
22. Yu ZF, Kong LD, Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. J Ethnopharmacol 2002;83:161-5. (Pubitemid 36164742)
23. Selvam R, Subramanian L, Gayathri R, Angayarkanni N. The anti-oxidant activity of turmeric (Curcuma longa). J Ethnopharmacol 1995;47:59-67.
24. Anbu Jeba Sunilson J, Suraj R, Rejitha G, Anandarajagopal K, Anita Gnana Kumari, AV, Promwichit P. In vitro antimicrobial evaluation of Zingiber officinale, Curcuma longa and Alpinia galanga extracts as natural food preservatives. Am J Food Technol 2009;4:192-200.
25. Mishra RK, Singh SK. Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice. Contraception 2009;79:479-87.
26. Subramanian L, Selvam R. Prevention of C4-induced hepatotoxicity by aqueous extract of turmeric. Nutr Res 1999;19:429-41. (Pubitemid 29164845)
27. Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial. Inflammopharmacology 2013;21:129-36.
28. Gomis DB, Tamayo DM, Alonso JM. Determination of monosaccharides in cider by reversed-phase liquid chromatography. Anal Chim Acta 2001;436:173-80.
29. United States Pharmacopeia (USP) 35-NF30, Vol. 1. 2012. 957.
30. Chandrasekaran CV, Sundarajan K, David K, Agarwal A. In vitro efficacy and safety of poly-herbal formulations. Toxicol in vitro 2010;24:885-97.
31. Chandrasekaran CV, Edwin Jothie R, Kapoor P, Gupta A, Agarwal A. Optimization of cell-based assays to quantify the anti-inflammatory/allergic potential of test substances in 96-well format. Inflammopharmacology 2011;19:169-81.
32. Plaeger SF. Clinical immunology and traditional herbal medicines. Clin Diagn Lab Immunol 2003;10:337-8. (Pubitemid 36592955)
33. Jayathirtha MG, Mishra SH. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine 2004;11:361-5. (Pubitemid 38657468)
34. Kim KI, Shin KS, Jun WJ, Hong BS, Shin DH, Cho HY, et al. Effects of polysaccharides from rhizomes of Curcuma zedoaria on macrophage functions. Biosci Biotechnol Biochem 2001;65:2369-77. (Pubitemid 33615697)
35. Kim AJ, Kim YO, Shim JS, Hwang JK. Immunostimulating activity of crude polysaccharide extract isolated from Curcuma xanthorrhiza Roxb. Biosci Biotechnol Biochem 2007;71:1428-38.
36. Madan B, Gade WN, Ghosh B. Curcuma longa activates NF-kappaB and promotes adhesion of neutrophils to human umbilical vein endothelial cells. J Ethnopharmacol 2001;75:25-32. (Pubitemid 32224869)
37. Zhai Z, Liu Y, Wu L, Senchina DS, Wurtele ES, Murphy PA, et al. Enhancement of innate and adaptive immune functions by multiple Echinacea species. J Med Food 2007;10:423-34. (Pubitemid 47493488)
38. Yegnanarayan R, Saraf AP, Balwani JH. Comparison of anti-inflammatory activity of various extracts of Curcuma longa (Linn.). Indian J Med Res 1976;64:601-8.