A hydrophobic surface is essential to inhibit the aggregation of a tau-protein-derived hexapeptide

Journal of the American Chemical Society

Volumn 135, Issue 18, 2013, Pages 6846-6852

  Zheng, Jing ^a   Baghkhanian, Arya M ^a   Nowick, James S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEXAPEPTIDE; HYDROPHOBIC SURFACES; INHIBITION PROCESS; LEUCINE RESIDUES; MACROCYCLICS; SEQUENCE ISOMERS;

AMINO ACIDS; PEPTIDES; SURFACE CHEMISTRY;

HYDROPHOBICITY;

ALANINE; HEXAPEPTIDE; LEUCINE; LYSINE; MUTANT PROTEIN; PHF6 PEPTIDE; SERINE; TAU PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FLUORESCENCE ANALYSIS; HYDROPHOBICITY; INHIBITION KINETICS; PROTEIN AGGREGATION; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SURFACE PROPERTY;

HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OLIGOPEPTIDES; SURFACE PROPERTIES; TAU PROTEINS;

EID: 84877302095     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja310817d     Document Type: Article

References (18)

1. Mandelkow, E.; von Bergen, M.; Biernat, J.; Mandelkow, E. M. Brain Pathol. 2007, 17, 83-90
2. von Bergen, M.; Friedhoff, P.; Biernat, J.; Heberle, J.; Mandelkow, E. M.; Mandelkow, E. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 5129-5134
3. Sawaya, M. R.; Sambashivan, S.; Nelson, R.; Ivanova, M. I.; Sievers, S. A.; Apostol, M. I.; Thompson, M. J.; Balbirnie, M.; Wiltzius, J. J.; McFarlane, H. T.; Madsen, A. O.; Riekel, C.; Eisenberg, D. Nature 2007, 447, 453-457
4. Petkova, A. T.; Yau, W. M.; Tycko, R. Biochemistry 2006, 45, 498-512
5. Walsh, P.; Simonetti, K.; Sharpe, S. Structure 2009, 17, 417-426
6. A recent solid-state NMR study of tau fibrils reveals that the VQIVYK sequence is located in the β-sheet core of the fibril, and this core region shows parallel, in-register β-sheet structure. Daebel, V.; Chinnathambi, S.; Biernat, J.; Schwalbe, M.; Habenstein, B.; Loquet, A.; Akoury, E.; Tepper, K.; Müller, H.; Baldus, M.; Griesinger, C.; Zweckstetter, M.; Mandelkow, E.; Vijayan, V.; Lange, A. J. Am. Chem. Soc. 2012, 134, 13982-13989
7. Goux, W. J.; Kopplin, L.; Nguyen, A. D.; Leak, K.; Rutkofsky, M.; Shanmuganandam, V. D.; Sharma, D.; Inouye, H.; Kirschner, D. A. J. Biol. Chem. 2004, 279, 26868-26875
8. Friedhoff, P.; Schneider, A.; Mandelkow, E. M.; Mandelkow, E. Biochemistry 1998, 37, 10223-10230
9. Zheng, J.; Liu, C.; Sawaya, M. R.; Vadla, B.; Khan, S.; Woods, R. J.; Eisenberg, D.; Goux, W. J.; Nowick, J. S. J. Am. Chem. Soc. 2011, 133, 3144-3157
10. Nowick, J. S.; Lam, K. S.; Khasanova, T. V.; Kemnitzer, W. E.; Maitra, S.; Mee, H. T.; Liu, R. W. J. Am. Chem. Soc. 2002, 124, 4972-4973
11. Nowick, J. S.; Brower, J. O. J. Am. Chem. Soc. 2003, 125, 876-877
12. Woods, R. J.; Brower, J. O.; Castellanos, E.; Hashemzadeh, M.; Khakshoor, O.; Russu, W. A.; Nowick, J. S. J. Am. Chem. Soc. 2007, 129, 2548-2558
13. Toniolo, C.; Palumbo, M. Biopolymers 1977, 16, 219-224
14. 7 residue
15. Takahashi, T.; Mihara, H. Acc. Chem. Res. 2008, 41, 1309-1318
16. Funke, S. A.; Willbold, D. Curr. Pharm. Des. 2012, 18, 755-767
17. Rojas Quijano, F. A.; Morrow, D.; Wise, B. M.; Brancia, F. L.; Goux, W. J. Biochemistry 2006, 45, 4638-4652
18. Moore, C. L.; Huang, M. H.; Robbennolt, S. A.; Voss, K. R.; Combs, B.; Gamblin, T. C.; Goux, W. J. Biochemistry 2011, 50, 10876-10886