메뉴 건너뛰기




Volumn 13, Issue 6 SUPPL., 2013, Pages 11-19

13 years of trabectedin, 5 years of Yondelis®: What have we learnt?

Author keywords

doxorubicin; front line therapy; ifosfamide; safety; soft tissue sarcoma; targeted therapy; trabectedin; Yondelis

Indexed keywords

DOXORUBICIN; IFOSFAMIDE; TRABECTEDIN;

EID: 84877297872     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.13.49     Document Type: Conference Paper
Times cited : (11)

References (35)
  • 1
    • 70249101414 scopus 로고    scopus 로고
    • Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized Phase II study of two different schedules
    • Demetri GD, Chawla SP, von Mehren M et al. Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized Phase II study of two different schedules. J. Clin. Oncol. 27(25), 4188-4196 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.25 , pp. 4188-4196
    • Demetri, G.D.1    Chawla, S.P.2    Von Mehren, M.3
  • 2
    • 0036189675 scopus 로고    scopus 로고
    • Progression-free rate as the principal end-point for Phase II trials in soft tissue sarcomas
    • EORTC Soft Tissue and Bone Sarcoma Group
    • Van Glabbeke M, Verweij J, Judson I, Nielsen OS; EORTC Soft Tissue and Bone Sarcoma Group. Progression-free rate as the principal end-point for Phase II trials in soft tissue sarcomas. Eur. J. Cancer 38(4), 543-549 (2002).
    • (2002) Eur. J. Cancer , vol.38 , Issue.4 , pp. 543-549
    • Van Glabbeke, M.1    Verweij, J.2    Judson, I.3    Nielsen, O.S.4
  • 3
    • 70350068771 scopus 로고    scopus 로고
    • Mapping the literature: Role of trabectedin as a new chemotherapy option in advanced pretreated soft tissue sarcoma
    • Le Cesne A, Domont J, Cioffi A et al. Mapping the literature: role of trabectedin as a new chemotherapy option in advanced pretreated soft tissue sarcoma. Drugs Today (Barc). 45(6), 403-421 (2009).
    • (2009) Drugs Today (Barc) , vol.45 , Issue.6 , pp. 403-421
    • Le Cesne, A.1    Domont, J.2    Cioffi, A.3
  • 4
    • 20044372153 scopus 로고    scopus 로고
    • Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial
    • Le Cesne A, Blay JY, Judson I et al. Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial. J. Clin. Oncol. 23(3), 576-584 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.3 , pp. 576-584
    • Le Cesne, A.1    Blay, J.Y.2    Judson, I.3
  • 5
    • 1542398698 scopus 로고    scopus 로고
    • Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients
    • Yovine A, Riofrio M, Blay JY et al. Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients. J. Clin. Oncol. 22(5), 890-899 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.5 , pp. 890-899
    • Yovine, A.1    Riofrio, M.2    Blay, J.Y.3
  • 6
    • 2342461682 scopus 로고    scopus 로고
    • Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy
    • Garcia-Carbonero R, Supko JG, Manola J et al. Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy. J. Clin. Oncol. 22(8), 1480-1490 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.8 , pp. 1480-1490
    • Garcia-Carbonero, R.1    Supko, J.G.2    Manola, J.3
  • 7
    • 0242522296 scopus 로고    scopus 로고
    • Therapeutic impact of ET-743 (Yondelis; trabectedin), a new marine-derived compound, in sarcoma
    • Jimeno J, Maki RG, Casali P et al. Therapeutic impact of ET-743 (Yondelis; trabectedin), a new marine-derived compound, in sarcoma. Curr. Opin. Orthop. 14(6), 419-428 (2003).
    • (2003) Curr. Opin. Orthop. , vol.14 , Issue.6 , pp. 419-428
    • Jimeno, J.1    Maki, R.G.2    Casali, P.3
  • 8
    • 57349160298 scopus 로고    scopus 로고
    • Translating targets into treatment: Changes in trial methodology and treatment approaches for soft tissue sarcomas
    • Perry MC (Ed.) American Society of Clinical Oncology, Alexandria, VA, USA
    • Verweij J, van Glabbeke M. Translating targets into treatment: changes in trial methodology and treatment approaches for soft tissue sarcomas. In: Classification and Treatment of Soft Tissue Sarcomas Educational Book. Perry MC (Ed.). American Society of Clinical Oncology, Alexandria, VA, USA, 522-530 (2003).
    • (2003) Classification and Treatment of Soft Tissue Sarcomas Educational Book , pp. 522-530
    • Verweij, J.1    Van Glabbeke, M.2
  • 9
    • 79957579501 scopus 로고    scopus 로고
    • Topoisomerase II-alpha protein expression and histological response following doxorubicin-based induction chemotherapy predict survival of locally advanced soft tissues sarcomas
    • Ruiz-Soto R, Auger N, Tournay E. Topoisomerase II-alpha protein expression and histological response following doxorubicin-based induction chemotherapy predict survival of locally advanced soft tissues sarcomas. Eur. J. Cancer 47(9), 1319-1327 (2011).
    • (2011) Eur. J. Cancer , vol.47 , Issue.9 , pp. 1319-1327
    • Ruiz-Soto, R.1    Auger, N.2    Tournay, E.3
  • 10
    • 34347214071 scopus 로고    scopus 로고
    • Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: A retrospective study
    • Grosso F, Jones RL, Demetri GD et al. Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study. Lancet Oncol. 8(7), 595-602 (2007).
    • (2007) Lancet Oncol , vol.8 , Issue.7 , pp. 595-602
    • Grosso, F.1    Jones, R.L.2    Demetri, G.D.3
  • 11
    • 84873733013 scopus 로고    scopus 로고
    • Growth modulation index as metric of clinical benefit assessment among advanced soft tissue sarcoma patients receiving trabectedin as a salvage therapy
    • Penel N, Demetri GD, Blay JY et al. Growth modulation index as metric of clinical benefit assessment among advanced soft tissue sarcoma patients receiving trabectedin as a salvage therapy. Ann. Oncol. 24(2), 537-42 (2012).
    • (2012) Ann. Oncol. , vol.24 , Issue.2 , pp. 537-542
    • Penel, N.1    Demetri, G.D.2    Blay, J.Y.3
  • 12
    • 84877309364 scopus 로고    scopus 로고
    • Growth modulation index and RECIST-based STBSG-EORTC criteria for the assessment of drug activity in advanced soft tissue sarcoma (ASTS) patients (pts)
    • Abstract 10014
    • Cousin S, Blay JY, Bertucci F et al. Growth modulation index and RECIST-based STBSG-EORTC criteria for the assessment of drug activity in advanced soft tissue sarcoma (ASTS) patients (pts). J. Clin. Oncol. 30(Suppl.), Abstract 10014 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL.
    • Cousin, S.1    Blay, J.Y.2    Bertucci, F.3
  • 13
    • 84864348875 scopus 로고    scopus 로고
    • A retrospective pooled analysis of trabectedin safety in 1,132 patients with solid tumors treated in Phase II clinical trials
    • Le Cesne A, Yovine A, Blay JY et al. A retrospective pooled analysis of trabectedin safety in 1,132 patients with solid tumors treated in Phase II clinical trials. Invest. New Drugs 30(3), 1193-1202 (2012).
    • (2012) Invest. New Drugs , vol.30 , Issue.3 , pp. 1193-1202
    • Le Cesne, A.1    Yovine, A.2    Blay, J.Y.3
  • 14
    • 18144448739 scopus 로고    scopus 로고
    • Randomized Phase II study of docetaxel versus doxorubicin in first- and second-line chemotherapy for locally advanced or metastatic soft tissue sarcomas in adults: A study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
    • Verweij J, Lee SM, Ruka W et al. Randomized Phase II study of docetaxel versus doxorubicin in first- and second-line chemotherapy for locally advanced or metastatic soft tissue sarcomas in adults: a study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J. Clin. Oncol. 18(10), 2081-2086 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , Issue.10 , pp. 2081-2086
    • Verweij, J.1    Lee, S.M.2    Ruka, W.3
  • 15
    • 18844475497 scopus 로고    scopus 로고
    • Effect of high-dose ifosfamide in advanced soft tissue sarcomas. A multicentre Phase II study of the EORTC Soft Tissue and Bone Sarcoma Group
    • Nielsen OS, Judson I, van Hoesel Q et al. Effect of high-dose ifosfamide in advanced soft tissue sarcomas. A multicentre Phase II study of the EORTC Soft Tissue and Bone Sarcoma Group. Eur. J. Cancer 36(1), 61-67 (2000).
    • (2000) Eur. J. Cancer , vol.36 , Issue.1 , pp. 61-67
    • Nielsen, O.S.1    Judson, I.2    Van Hoesel, Q.3
  • 16
    • 18844475615 scopus 로고    scopus 로고
    • Randomised Phase II trial of PEGylated liposomal doxorubicin (DOXIL/CAELYX) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: A study by the EORTC Soft Tissue and Bone Sarcoma Group
    • Judson I, Radford JA, Harris M et al. Randomised Phase II trial of PEGylated liposomal doxorubicin (DOXIL/CAELYX) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: a study by the EORTC Soft Tissue and Bone Sarcoma Group. Eur. J. Cancer 37(7), 870-877 (2001).
    • (2001) Eur. J. Cancer , vol.37 , Issue.7 , pp. 870-877
    • Judson, I.1    Radford, J.A.2    Harris, M.3
  • 17
    • 0029001008 scopus 로고
    • High-dose ifosfamide: Circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas
    • Le Cesne A, Antoine E, Spielmann M et al. High-dose ifosfamide: circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas. J. Clin. Oncol. 13(7), 1600-1608 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , Issue.7 , pp. 1600-1608
    • Le Cesne, A.1    Antoine, E.2    Spielmann, M.3
  • 18
    • 81155149886 scopus 로고    scopus 로고
    • Trabectedin in advanced uterine leiomyosarcomas: A retrospective case series analysis from two reference centers
    • Sanfilippo R, Grosso F, Jones RL et al. Trabectedin in advanced uterine leiomyosarcomas: a retrospective case series analysis from two reference centers. Gynecol. Oncol. 123(3), 553-556 (2011).
    • (2011) Gynecol. Oncol. , vol.123 , Issue.3 , pp. 553-556
    • Sanfilippo, R.1    Grosso, F.2    Jones, R.L.3
  • 19
    • 77956287630 scopus 로고    scopus 로고
    • Trabectedin: An emerging therapeutic option in soft tissue sarcoma
    • Blay JY. Trabectedin: an emerging therapeutic option in soft tissue sarcoma. Eur. J. Clin. Med. Oncol. 1(2) (2009).
    • (2009) Eur. J. Clin. Med. Oncol. , vol.1 , Issue.2
    • Blay, J.Y.1
  • 20
    • 84655170216 scopus 로고    scopus 로고
    • Activity of trabectedin in desmoplastic small round cell tumor
    • López-González A, Cantos B, Tejerina E, Provencio M. Activity of trabectedin in desmoplastic small round cell tumor. Med. Oncol. 28(Suppl. 1), S644-S646 (2011).
    • (2011) Med. Oncol. , vol.28 , Issue.SUPPL. 1
    • López-González, A.1    Cantos, B.2    Tejerina, E.3    Provencio, M.4
  • 21
    • 77955228557 scopus 로고    scopus 로고
    • Response to trabectedin treatment in a highly pretreated patient with an advanced meningeal hemangiopericytoma
    • Martinez-Trufero J, Alfaro J, Felipo F, Alvarez M, Madani J, Cebollero A. Response to trabectedin treatment in a highly pretreated patient with an advanced meningeal hemangiopericytoma. Anticancer Drugs 21(8), 795-798 (2010).
    • (2010) Anticancer Drugs , vol.21 , Issue.8 , pp. 795-798
    • Martinez-Trufero, J.1    Alfaro, J.2    Felipo, F.3    Alvarez, M.4    Madani, J.5    Cebollero, A.6
  • 22
    • 79960983277 scopus 로고    scopus 로고
    • Efficacy of trabectedin in metastatic solitary fibrous tumor
    • Chaigneau L, Kalbacher E, Thiery-Vuillemin A et al. Efficacy of trabectedin in metastatic solitary fibrous tumor. Rare Tumors 3(3), e29 (2011).
    • (2011) Rare Tumors , vol.3 , Issue.3
    • Chaigneau, L.1    Kalbacher, E.2    Thiery-Vuillemin, A.3
  • 23
    • 84867579960 scopus 로고    scopus 로고
    • A retrospective analysis of antitumour activity with trabectedin in translocationrelated sarcomas
    • Le Cesne AL, Cresta S, Maki RG et al. A retrospective analysis of antitumour activity with trabectedin in translocationrelated sarcomas. Eur. J. Cancer 48(16), 3036-3044 (2012).
    • (2012) Eur. J. Cancer , vol.48 , Issue.16 , pp. 3036-3044
    • Le Cesne, A.L.1    Cresta, S.2    Maki, R.G.3
  • 24
    • 84857530639 scopus 로고    scopus 로고
    • Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma
    • Gronchi A, Bui BN, Bonvalot S et al. Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma. Ann. Oncol. 23(3), 771-776 (2012).
    • (2012) Ann. Oncol. , vol.23 , Issue.3 , pp. 771-776
    • Gronchi, A.1    Bui, B.N.2    Bonvalot, S.3
  • 25
    • 84877246705 scopus 로고    scopus 로고
    • Trabectedin (T) in advanced, pre-treated synovial sarcoma (SS): A retrospective analysis of 61 patients from four European institutions and from the Italian Rare Cancer Network
    • Prague, Czech Republic, 14-17 November 2012
    • Sanfilippo R, Dileo P, Blay JY et al. Trabectedin (T) in advanced, pre-treated synovial sarcoma (SS): a retrospective analysis of 61 patients from four European institutions and from the Italian Rare Cancer Network. Presented at: 17th Annual Meeting of the Connective Tissue Oncology Society. Prague, Czech Republic, 14-17 November 2012.
    • 17th Annual Meeting of the Connective Tissue Oncology Society
    • Sanfilippo, R.1    Dileo, P.2    Blay, J.Y.3
  • 26
    • 84878730984 scopus 로고    scopus 로고
    • Trabectedin in soft tissue sarcomas (STS) carrying a chromosomal translocation: An exploratory analysis
    • Seattle, WA, USA, 1-3 November 2007 (Abstract 900)
    • Grosso F, Jones RL, Blay JY et al. Trabectedin in soft tissue sarcomas (STS) carrying a chromosomal translocation: an exploratory analysis. Presented at: 13th Annual Meeting of the Connective Tissue Oncology Society. Seattle, WA, USA, 1-3 November 2007 (Abstract 900).
    • 13th Annual Meeting of the Connective Tissue Oncology Society
    • Grosso, F.1    Jones, R.L.2    Blay, J.Y.3
  • 27
    • 84877308031 scopus 로고    scopus 로고
    • Randomized multicenter Phase III trial of trabectedin (T) versus doxorubicin-based chemotherapy as first-line therapy in patients with translocation-related sarcoma (TRS)
    • Abstract TPS10101
    • Blay JY, Leahy MG, Bui BN et al. Randomized multicenter Phase III trial of trabectedin (T) versus doxorubicin-based chemotherapy as first-line therapy in patients with translocation-related sarcoma (TRS). J. Clin. Oncol. 30(Suppl.), Abstract TPS10101 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL.
    • Blay, J.Y.1    Leahy, M.G.2    Bui, B.N.3
  • 28
    • 24944460785 scopus 로고    scopus 로고
    • Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: Multicenter Phase II and pharmacokinetic study
    • Garcia-Carbonero R, Supko JG, Maki RG et al. Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: multicenter Phase II and pharmacokinetic study. J. Clin. Oncol. 23(24), 5484-5492 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.24 , pp. 5484-5492
    • Garcia-Carbonero, R.1    Supko, J.G.2    Maki, R.G.3
  • 29
    • 58149186082 scopus 로고    scopus 로고
    • Phase i combination study of trabectedin and doxorubicin in patients with soft tissue sarcoma
    • Blay JY, von Mehren M, Samuels BL et al. Phase I combination study of trabectedin and doxorubicin in patients with soft tissue sarcoma. Clin. Cancer Res. 14(20), 6656-6662 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.20 , pp. 6656-6662
    • Blay, J.Y.1    Von Mehren, M.2    Samuels, B.L.3
  • 30
    • 84873261540 scopus 로고    scopus 로고
    • Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: An analysis of 181 patients of the French ATU compassionate use program
    • Blay JY, Italiano A, Ray-Coquard I et al. Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: an analysis of 181 patients of the French ATU compassionate use program. BMC Cancer 13, 64 (2013).
    • (2013) BMC Cancer , vol.13 , pp. 64
    • Blay, J.Y.1    Italiano, A.2    Ray-Coquard, I.3
  • 31
    • 84877263756 scopus 로고    scopus 로고
    • Rechallenge with trabectedin in patients with locally advanced or metastatic soft tissue sarcoma following drug holiday: The experience of the French Sarcoma Group (FSG)
    • Abstract 10062
    • Saada E, Rahal C, Ray-Coquard I et al. Rechallenge with trabectedin in patients with locally advanced or metastatic soft tissue sarcoma following drug holiday: the experience of the French Sarcoma Group (FSG). J. Clin. Oncol. 30(Suppl.), Abstract 10062 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL.
    • Saada, E.1    Rahal, C.2    Ray-Coquard, I.3
  • 34
    • 84877311310 scopus 로고    scopus 로고
    • Institut de cancérologie Gustave Roussy willejuif
    • Institut de cancérologie Gustave Roussy willejuif. Les essais cliniques à l'IGR. www.igr.fr/index.php?p-m=igrinter&p- a=essai&p-sa=cancer-12
    • Les Essais Cliniques À l'Igr


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.