Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients

Clinical Infectious Diseases

Volumn 56, Issue 10, 2013, Pages 1394-1400

  Oakes, Brendan ^a,b   Hoagland Henefield, Matthias ^b   Komaroff, Anthony L ^c   Erickson, Jessica L ^c   Huber, Brigitte T ^b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

CFS; HERV K18; HHV 6; HHV 7

Indexed keywords

COMPLEMENTARY DNA; SUPERANTIGEN; VIRUS DNA;

ANTIGEN EXPRESSION; ARTICLE; CHRONIC FATIGUE SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOGENOUS RETROVIRUS; GENE EXPRESSION; HUMAN; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SALIVA; VIRUS LOAD;

CASE-CONTROL STUDIES; COHORT STUDIES; DNA, VIRAL; ENDOGENOUS RETROVIRUSES; FATIGUE SYNDROME, CHRONIC; HERPESVIRUS 6, HUMAN; HERPESVIRUS 7, HUMAN; HUMANS; RNA, VIRAL; ROSEOLOVIRUS INFECTIONS; STATISTICS, NONPARAMETRIC; SUPERANTIGENS; VIRAL LOAD; VIRAL PROTEINS;

EID: 84877294867     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cit086     Document Type: Article

References (40)

1. Jason L, Richman J, Rademaker A, et al. A community-based study of chronic fatigue syndrome. Arch Intern Med 1999; 159:2129-37.
2. Prins JB, van der Meer JWM, Bleijenberg G. Chronic fatigue syndrome. Lancet 2006; 367:346-55.
3. Afari N, Buchwald D. Chronic fatigue syndrome: a review. Am J Psych 2003; 160:221-36.
4. Hickie I, Davenport T, Wakefield D, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ 2006; 333:575.
5. Lorusso L, Mikhaylova SV, Capelli E, Ferrari D, Ngonga GK, Ricevuti G. Immunological aspects of chronic fatigue syndrome. Autoimmun Rev 2009; 8:287-91.
6. Enbom M, Linde A, Evengård B. No evidence of active infection with human herpesvirus 6 (HHV-6) or HHV-8 in chronic fatigue syndrome. J Clin Microbiol 2000; 38:2457.
7. Josephs SF, Henry B, Balachandran N, et al. HHV-6 reactivation in chronic fatigue syndrome. Lancet 1991; 337:1346-7.
8. Di Luca D, Zorzenon M, Mirandola P, Colle R, Botta GA, Cassai E. Human herpesvirus 6 and human herpesvirus 7 in chronic fatigue syndrome. J Clin Microbiol 1995; 33:1660-61.
9. Sairenji T, Yamanishi K, Tachibana Y, Bertoni G, Kurata T. Antibody responses to Epstein-Barr virus, human herpesvirus 6 and human herpesvirus 7 in patients with chronic fatigue syndrome. Intervirology 1995; 38:269-73.
10. Ablashi DV, Eastman HB, Owen CB, et al. Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients. J Clin Virol 2000; 16:179-91.
11. Nicolson GL, Gan R, Haier J. Multiple co-infections (mycoplasma, chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms. APMIS 2003; 111:557-66.
12. Chapenko S, Krumina A, Kozireva S, et al. Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome. J Clin Virol 2006; 37(Supplement 1):S47-51.
13. Komaroff AL. Is human herpesvirus-6 a trigger for chronic fatigue syndrome? J Clin Virol 2006; 37(Supplement 1):S39-46.
14. Buchwald D, Cheney P, Peterson D, et al. A Chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Ann Intern Med 1992; 116:103-13.
15. Zorzenon M, Rukh G, Botta GA, Colle R, Barsanti LA, Ceccherini-Nelli L. Active HHV-6 infection in chronic fatigue syndrome patients from Italy. J Chron Fatigue Syndr 1996; 2:3-12.
16. Patnaik M, Komaroff A, Conley E, Ojo-Amaize E, Peter J. Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with chronic fatigue syndrome. J Infect Dis 1995; 172:1364-67.
17. Wagner M, Krueger GRF, Ablashi DV, Whitman JE. Chronic fatigue syndrome (CFS): a critical evaluation of testing for active human herpesvirus-6 (HHV-6) infection. JChron Fatigue Syndr 1996; 2:3-16.
18. Chapenko S, Krumina A, Logina I, et al. Association of active human herpesvirus-6,-7 and parvovirus B19 infection with clinical outcomes in patients with myalgic encephalomyelitis/chronic fatigue syndrome. Advances in Virology 2012; 2012:7.
19. Koelle DM, Barcy S, Huang M-L, et al. Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome. Clin Infect Dis 2002; 35:518-25.
20. Cameron B, Flamand L, Juwana H, et al. Serological and virological investigation of the role of the herpesviruses EBV, CMV, and HHV-6 in post-infective fatigue syndrome. J Med Virol 2010; 82:1684-88.
21. Reeves WC, Stamey FR, Black JB, Mawle AC, Stewart JA, Pellett PE. Human herpesviruses 6 and 7 in chronic fatigue syndrome: a casecontrol study. Clin Infect Dis 2000; 31:48-52.
22. Wallace Hn, Natelson B, Gause W, Hay J. Human herpesviruses in chronic fatigue syndrome. Clin Diagnos Lab Immunol 1999; 6:216-23.
23. Caselli E, Di Luca D. Molecular biology and clinical associations of roseoloviruses human herpesvirus 6 and human herpesvirus 7. New Microbiologica 2007; 30:173-87.
24. Sicat J, Sutkowski N, Huber BT. Expression of human endogenous retrovirus HERV-K18 superantigen is elevated in juvenile rheumatoid arthritis. J Rheumatol 2005; 32:1821-31.
25. Stauffer Y, Marguerat S, Meylan F, et al. Interferon-α-induced endogenous superantigen: a model linking environment and autoimmunity. Immunity 2001; 15:591-601.
26. Sutkowski N, Conrad B, Thorley-Lawson DA, Huber BT. Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen. Immunity 2001; 15:579-89.
27. Tai AK, Luka J, Ablashi D, Huber BT. HHV-6A infection induces expression of HERV-K18-encoded superantigen. J Clin Virol 2009; 46: 47-48.
28. Turcanova VL, Bundgaard B, Höllsberg P. Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigen. J Clin Virol 2009; 46:15-19.
29. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994; 121:953-9.
30. Hadinoto V, Shapiro M, Sun CC, Thorley-Lawson DA. The dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral output. PLoS Pathog 2009; 5:e1000496.
31. Oakes B, Tai A, Cingoz O, et al. Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences. Retrovirology 2010; 7:109.
32. Karlsson T, Mannonen L, Loginov R, Lappalainen M, Höckerstedt K, Lautenschlager I. Development of a new quantitative real-time HHV-6-PCR and monitoring of HHV-6 DNAaemia after liver transplantation. J Virolog Methods 2012; 181:25-36.
33. Lou J, Wu Y, Cai M, Wu X, Shang S. Subtype-specific, probe-based, real-time PCR for detection and typing of human herpesvirus-6 encephalitis from pediatric patients under the age of 2 years. Diagnostic Microbiol Infectious Dis 2011; 70:223-29.
34. Fernandez C, Boutolleau D, Manichanh C, Mangeney N, Agut H, Gautheret-Dejean A. Quantitation of HHV-7 genome by real-time polymerase chain reaction assay using MGB probe technology. J Virol Methods 2002; 106:11-6.
35. Hsiao FC, Lin M, Tai A, Chen G, Huber BT. Cutting edge: Epstein-Barr virus transactivates the HERV-K18 superantigen by docking to the human complement receptor 2 (CD21) on primary B cells. J Immunol 2006; 177:2056-60.
36. White PD, Thomas JM, Amess J, Grover SA, Kangro HO, Clare AW. The existence of a fatigue syndrome after glandular fever. Psycholog Med 1995; 25:907-16.
37. Bujak D, Dornbush R, Sabbeth B, Weinstein A. Fibromyalgia and chronic fatigue syndrome induced by Lyme disease. Arthritis Rheum 1993; 36(Suppl):S42.
38. Wildman MJ, Smith EG, Groves J, Beattie JM, Caul EO, Ayres JG. Chronic fatigue following infection by Coxiella burnetii (Q fever): 10-year follow-up of the 1989 UK outbreak cohort. QJM 2002; 95:527-38.
39. Kosuge H. HHV-6, 7 and their related diseases. J Dermatol Sci 2000; 22:205-12.
40. Komaroff A, Cho T. Role of infection and neurologic dysfunction in chronic fatigue syndrome. Semin Neurol 2011; 31:325-37.