Increased 99mTc-sestamibi washout reflects impaired myocardial contractile and relaxation reserve during dobutamine stress due to mitochondrial dysfunction in dilated cardiomyopathy patients

Journal of the American College of Cardiology

Volumn 61, Issue 19, 2013, Pages 2007-2017

  Hayashi, Daisuke ^a,b   Ohshima, Satoru ^a,c   Isobe, Satoshi ^a   Cheng, Xian Wu ^a   Unno, Kazumasa ^a   Funahashi, Hidehito ^a,c   Shinoda, Norihiro ^a   Okumura, Takahiro ^a   Hirashiki, Akihiro ^a   Kato, Katsuhiko ^a   Murohara, Toyoaki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Tokai Central Hospital of Japan Mutual Aid Association of Public School Teachers   (Japan)

^c Tsushima City Hospital   (Japan)

Author keywords

99mTc sestamibi scintigraphy; dilated cardiomyopathy; dobutamine stress test; mitochondrial dysfunction; myocardial contractile reserve

Indexed keywords

DOBUTAMINE; MESSENGER RNA; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; NORADRENALIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE SEVERITY; ELECTRON MICROSCOPY; ELECTRON TRANSPORT; FEMALE; GLYCOGEN METABOLISM; HEART CATHETERIZATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE BIOPSY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; HEART SCINTISCANNING; HUMAN; HUMAN TISSUE; MALE; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRESS;

ADULT; AGED; CARDIOMYOPATHY, DILATED; ECHOCARDIOGRAPHY, STRESS; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; FEMALE; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA, HEART; MYOCARDIAL CONTRACTION; MYOCARDIUM; RNA, MESSENGER; TECHNETIUM TC 99M SESTAMIBI;

EID: 84877280034     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.01.074     Document Type: Article

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