99mTc-sestamibi kinetics predict myocardial viability in a perfused rat heart model

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 35, Issue 3, 2008, Pages 570-578

  Liu, Zhonglin ^b   Okada, David R ^a   Johnson III, Gerald ^a   Hocherman, Sonia D ^a   Beju, Delia ^c   Okada, Robert D ^a  

^a UNIVERSITY OF TULSA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

99mTc sestamibi; Ischemia; Kinetics; Myocardium; Reperfusion; Viability

Indexed keywords

CALCIUM; CREATINE KINASE; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; TRIPHENYLTETRAZOLIUM; DIAGNOSTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORRELATION ANALYSIS; DRUG INFUSION; ENZYME ASSAY; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART PERFUSION; ISOLATED HEART; KINETICS; MALE; MODEL; NONHUMAN; PREDICTION; QUANTITATIVE ANALYSIS; RAT; SPECTRUM; STAINING; STATISTICAL SIGNIFICANCE; STUNNED HEART MUSCLE; TRANSMISSION ELECTRON MICROSCOPY; UREA CYCLE; ANIMAL; COMPUTER ASSISTED DIAGNOSIS; DISEASE MODEL; EVALUATION; HEART; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; PERFUSION; REPERFUSION INJURY; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT;

ANIMALS; DISEASE MODELS, ANIMAL; HEART; IMAGE INTERPRETATION, COMPUTER-ASSISTED; KINETICS; MALE; METABOLIC CLEARANCE RATE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TECHNETIUM TC 99M SESTAMIBI;

EID: 43349088834     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-007-0549-4     Document Type: Article

References (28)

1. Verani MS, Jeroudi M, Mahmarian JJ, Boyce TM, Borges-Neto S, Patel B, et al. Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technitium-99m hexakis 2-methoxyisobutyl isonitrile. J Am Coll Cardiol 1988;12:1573-81.
2. Sinusas AJ, Trautman KA, Bergin JD, Watson DD, Ruiz M, Smith WH, et al. Quantification of area at risk during coronary occlusion and degree of myocardial salvage after reperfusion with technetium-99m methoxyisobutyl isonitrile. Circulation 1990;82:1424-37.
3. Beanlands RSB, Dawood F, Wen W-H, McLaughlin PR, Butany J, D'Amati G, et al. Are the kinetics of technetium-99m methoxyisobutyl isonitrile affected by cell metabolism and viability? Circulation 1990;82:1802-14.
4. Okada RD, Glover DK, Nguyen KN, Johnson G III. Technetium-99m sestamibi kinetics in reperfused canine myocardium. Eur J Nucl Med 1995;22:600-7.
5. Freeman I, Gunwald AM, Hoory S, Bodenheimer MM. Effect of coronary occlusion and myocardial viability on myocardial activity of technetium-99m-sestamibi. J Nucl Med 1991;32:292-8.
6. Glover D, Okada RD. Myocardial technetium 99m sestamibi kinetics after reperfusion in a canine model. Am Heart J 1993;125:657.
7. Takehana K, Ruiz M, Petruzella FD, Watson DD, Beller GA, Glover DK. 99mTc-sestamibi defect magnitude predicts the amount of viable myocardium after coronary reperfusion despite the presence of severe residual stenosis. J Nucl Cardiol 2001;8:40-8.
8. Liu Z, Johnson G III, Beju D, Okada RD. Detection of myocardial viability in ischemic-reperfused rat hearts by Tc-99m sestamibi kinetics. J Nucl Cardiol 2001;8:677-86.
9. Kaufman GJ, Boyne TS, Watson DD, Smith WH, Beller GA. Comparison of rest thallium-201 imaging and rest technetium-99m sestamibi imaging for assessment of myocardial viability in patients with coronary artery disease and severe left ventricular dysfunction. J Am Coll Cardiol 1996;27:1592-7.
10. 18FDG PET on clinical outcome in coronary artery disease. J Nucl Med 1997;38:742-8.
11. Chin BB, Esposito G, Kraitchman DL. Myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine (99m)Tc-sestamibi SPECT in canine stunning and subendocardial infarction. J Nucl Med 2002;43:540-50.
12. Maublant JC, Gachon P, Moins N. Hexakis (2-methoxy isobutylisonitrile) technetium-99m and thallium-201 chloride: uptake and release in cultured myocardial cells. J Nucl Med 1988;29:48-54.
13. Morguet A, Munz D, Klein H, Pich S, Conrady A, Nebendahl K, et al. Myocardial distribution of indium-111-antimyosin Fab and technetium-99m- sestamibi in experimental nontransmural infarction. J Nucl Med 1992;33:223-8.
14. Merhi Y, Arsenault A, Latour J. Time course of technetium-99m sestamibi myocardial distribution in dogs with a permanent or transient coronary occlusion. Eur J Nucl Med 1994;21:481-7.
15. Piwnica-Worms D, Kronauge JF, Delmon L, Holman BL, Marsh JD, Jones AG. Effect of metabolic inhibition on technetium-99m-MIBI kinetics in cultured check myocardial cells. J Nucl Med 1990;31:464-72.
16. Merhi Y, Latour JG, Arsenault A, Rousseau G. Effect of coronary reperfusion on technetium-99m methoxyisobutylisonitrile uptake by viable and necrotic myocardium in the dog. Eur J Nucl Med 1992;19:503-10.
17. Weinstein H, Reinhardt CP, Wironen JF, Leppo JA. Myocardial uptake of thallium 201 and technetium 99m-labeled sestamibi after ischemia and reperfusion: comparison by quantitative dual-tracer autoradiography in rabbits. J Nucl Cardiol 1994;1:351-64.
18. DeCoster PM, Wijns W, Cauwe F, Robert A, Beckers C, Melin JA. Technetium-99m-hexakis-2-methoxyisobutyl isonitrile in experimental myocardial infarction. Circulation 1990;82:2152-62.
19. Li QS, Soot G, Franceschi D, Wagner HN, Becker LC. Comparison of RP-30 and SQ 32014: myocardial uptake and redistribution in dogs with temporary coronary artery occlusion (abstract). J Nucl Med 1988;29:819.
20. 99mTc-sestamibi with thallium reinjection and [18F]-fluorodeoxyglucose. Circulation 1994;89:578-87.
21. Leon AR, Eisner RL, Martin SE, Schmarkey LS, Aaron AM, Boyers AS, et al. Comparison of single photon emission computed tomography (SPECT) myocardial imaging with thallium-201 and technetium-99m-sestamibi defects. J Am Coll Cardiol 1992;20:1612-25.
22. Sawata SG, Allman KC, Muzik O, Beanlands RSWB, Wolfe ER Jr, Gross M, et al. Positron emission tomography detects evidence of viability in rest technetium-99m sestamibi defects. J Am Coll Cardiol 1994;23:92-8.
23. Ford WR, Clanachan AS, Hiley CR, Jugdutt BI. Angiotensin II reduces infarct size and has no effect on post-ischaemic contractile dysfunction in isolated rat hearts. Br J Pharmacol 2001;134 1:38-45.
24. Carvalho M, Chiu ML, Kronauge JF, Kawamura M, Jones AG, Holman BL, et al. Subcellular distribution and analysis of technetium-99m MIBI in isolated perfused rat hearts. J Nucl Med 1992;33:1516-21.
25. Chiu ML, Kronauge JF, Piwnica-Worms D. Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts. J Nucl Med 1990;31:1646-53.
26. Piwnica-Worms D, Chiu ML, Kronauge JF. Divergent kinetics of 201Tl and 99mTc-sestamibi in cultured chick ventricular myocytes during ATP depletion. Circulation 1992;85:1531-41.
27. 99mTc-sestamibi uptake and retention during myocardial ischemia and reperfusion. Circulation 1993;87:2033-42.
28. Sinusas AJ, Watson DD, Cannon JM Jr, Beller GA. Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201. J Am Coll Cardiol 1989;14:1785-93.