Improvement of erectile function by Korean red ginseng (Panax ginseng) in a male rat model of metabolic syndrome

Asian Journal of Andrology

Volumn 15, Issue 3, 2013, Pages 395-399

  Kim, Sung Dae ^a   Kim, Young Joo ^a   Huh, Jung Sik ^a   Kim, Sae Woong ^b   Sohn, Dong Wan ^b  

^a Jeju National University School of Medicine   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Erectile dysfunction; Ginseng; Metabolic syndrome; Penis

Indexed keywords

ALDOSTERONE; CHOLESTEROL; CYCLIC GMP; FATTY ACID; GINSENG EXTRACT; GLUCOSE; INSULIN; TRANSFORMING GROWTH FACTOR BETA1;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; CHEMICAL PARAMETERS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORPUS CAVERNOSUM; ERECTILE DYSFUNCTION; FATTY ACID BLOOD LEVEL; GINSENG; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTRACAVERNOSAL PRESSURE; MALE; MEAN ARTERIAL PRESSURE; METABOLIC SYNDROME X; NONHUMAN; PENIS ERECTION; PLASMA RENIN ACTIVITY; PRESSURE MEASUREMENT; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ARTERIAL PRESSURE; CYCLIC GMP; DISEASE MODELS, ANIMAL; ERECTILE DYSFUNCTION; MALE; METABOLIC SYNDROME X; PANAX; PENILE ERECTION; PENIS; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, INBRED WKY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84877251436     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2012.159     Document Type: Article

References (29)

1. Pegge NC, Twomey AM, Vaughton K, Gravenor MB, Ramsey MW et al. The role of endothelial dysfunction in the pathophysiology of erectile dysfunction in diabetes and in determining response to treatment. Diabet Med 2006; 23: 873-8.
2. Ferrini MG, Kovanecz I, Sanchez S, Vernet D, Davila HH et al. Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat. Biol Reprod 2007; 76: 915-23.
3. Esposito K, Giugliano F, Martedi E, Feola G, Marfella R et al. High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care 2005; 28: 1201-3.
4. Kim SC. Insulin resistance and erectile dysfunction. Korean J Urol 2006; 47: 917-27.
5. Abate N, Chandalia M, Cabo-Chan AV Jr, Moe OW, Sakhaee K. The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Int 2004; 65: 386-92.
6. Lund Håheim L, Wisløff TF, Holme I, Nafstad P. Metabolic syndrome predicts prostate cancer in a cohort of middle-aged Norwegian men followed for 27 years. Am J Epidemiol 2006; 164: 769-74.
7. Kim SD, Cho SY, Sohn DW, Lee DS, Jeong MS et al. [The changes of the erectile function and histology of the corpus cavernosum in a rat model of metabolic syndrome]. Korean J Androl 2008; 26: 187-96.
8. Ko SH, Kwon HS, Kim SR, Moon SD, Ahn YB et al. Ramipril treatment suppresses islet fibrosis in otsuka long-evans tokushima fatty rats. Biochem Biophys Res Commun 2004; 316: 114-22.
9. Lee RK, Chughtai B, Te AE, Kaplan SA. Sexual function in men with metabolic syndrome. Urol Clin North Am 2012; 39: 53-62.
10. Corona G, Mannucci E, Ricca V, Lotti F, Boddi V et al. The age-related decline of testosterone is associated with different specific symptoms and signs in patients with sexual dysfunction. Int J Androl 2009; 32: 720-8.
11. Chughtai B, Lee RK, Te AE, Kaplan SA. Metabolic syndrome and sexual dysfunction. Curr Opin Urol 2011; 21: 514-8.
12. Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA et al. Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med 2000; 30: 328-38.
13. Heidler S, Temml C, Broessner C, Mock K, Rauchenwald M et al. Is the metabolic syndrome an independent risk factor for erectile dysfunction? J Urol 2007; 177: 651-4.
14. Matsuzaki G, Ishizaka N, Furuta K, Hongo M, Saito K et al. Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome. Eur J Pharmacol 2008; 587: 237-42.
15. Renna NF, Vazquez MA, Lama MC, Gonzalez ES, Miatello RM. Effect of chronic aspirin administration on an experimental model of metabolic syndrome. Clin Exp Pharmacol Physiol 2009; 36: 162-68.
16. Filippi S, Vignozzi L, Morelli A, Chavalmane AK, Sarchielli E et al. Testosterone partially ameliorates metabolic profile and erectile responsiveness to PDE5 inhibitors in an animal model of male metabolic syndrome. J Sex Med 2009; 6: 3274-88.
17. Vignozzi L, Morelli A, Sarchielli E, Comeglio P, Filippi S et al. Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbit. J Endocrinol 2012; 212: 71-84.
18. Morelli A, Comeglio P, Filippi S, Sarchielli E, Cellai I et al. Testosterone and farnesoid X receptor agonist INT-747 counteract high fat diet-induced bladder alterations in a rabbit model of metabolic syndrome. J Steroid Biochem Mol Biol 2012; 132: 80-92.
19. Lee WC, Chuang YC, Chiang PH, Chien CT, Yu HJ et al. Pathophysiological studies of overactive bladder and bladder motor dysfunction in a rat model of metabolic syndrome. J Urol 2011; 186: 318-25.
20. Cao J, Sodhi K, Puri N, Monu SR, Rezzani R et al. High fat diet enhances cardiac abnormalities in SHR rats: protective role of heme oxygenase-adiponectin axis. Diabetol Metab Syndr 2011; 3: 37.
21. Nagatomo F, Fujino H, Kondo H, Takeda I, Tsuda K et al. High-fat diet-induced reduction of peroxisome proliferator-activated receptor-c coactivator-1a messenger RNA levels and oxidative capacity in the soleus muscle of rats with metabolic syndrome. Nutr Res 2012; 32: 144-51.
22. Anraku M, Michihara A, Yasufuku T, Akasaki K, Tsuchiya D et al. The antioxidative and antilipidemic effects of different molecular weight chitosans in metabolic syndrome model rats. Biol Pharm Bull 2010; 33: 1994-8.
23. Blumentals WA, Gomez-Caminero A, Joo S, Vannappagari V. Should erectile dysfunction be considered as a marker for acute myocardial infarction? Results from a retrospective cohort study. Int J Impot Res 2004; 16: 350-3.
24. Choi Y, Park J, Choi H, Nam K. [Effects of composition of saponin fraction from Korean red ginseng in the relaxation of rabbit and rat corpus cavernosum]. J Ginseng Res 1999; 23: 13-20.
25. de Andrade E, de Mesquita AA, Claro Jde A, de Andrade PM, Ortiz V et al. Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian J Androl 2007; 9: 241-4.
26. Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK et al. Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction. Asian J Androl 2009; 11: 356-61.
27. Nehra A, Goldstein I, Pabby A, Nugent M, Huang YH et al. Mechanisms of venous leakage: A prospective clinicopathological correlation of corporeal function and structure. J Urol 1996; 156: 1320-9.
28. Ushiyama M, Morita T, Kuramochi T, Yagi S, Katayama S. Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide. Hypertens Res 2004; 27: 253-61.
29. Park K, Shin JW, Jeong SJ, Park DW, Son H et al. [Pathophysiologic investigation of vasculogenic erectile dysfunction using newly developed rat model]. Korean J Androl 2003; 21: 136-44.