Amyloid fibrils from readily available sources: Milk casein and lens crystallin proteins

Methods in Molecular Biology

Volumn 996, Issue , 2013, Pages 103-117

  Ecroyd, Heath ^a   Garvey, Megan ^b,c   Thorn, David C ^c   Gerrard, Juliet A ^d,e   Carver, John A ^c  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b MAX PLANCK RESEARCH UNIT FOR ENZYMOLOGY OF PROTEIN FOLDING   (Germany)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d UNIVERSITY OF CANTERBURY   (New Zealand)

^e CALLAGHAN INNOVATION   (New Zealand)

Author keywords

Amyloid fibrils; Bionanomaterials; Caseins; Crystallins; Lens proteins; Milk proteins; Protein aggregation; Small heat shock proteins

Indexed keywords

AMYLOID; BIOMIMETIC MATERIAL; CASEIN; CRYSTALLIN; LENS PROTEIN; MILK PROTEIN;

ARTICLE; BIOCOMPATIBILITY; BIOSENSOR; COW; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION;

EID: 84877148754     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-354-1_6     Document Type: Article

References (18)

1. Chiti F, Dobson CM (2006) Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem 75:333-366
2. Ecroyd H, Carver JA (2008) Unraveling the mysteries of protein folding and misfolding. IUBMB Life 60:769-774
3. Jiménez JL, Nettleton EJ, Bouchard M, Robinson CV, Dobson CM, Saibil HR (2002) The proto filament structure of insulin amyloid fibrils. Proc Natl Acad Sci USA 99:9196-9201
4. Fowler DM, Koulov AV, Balch WE, Kelly JW (2007) Functional amyloid - from bacteria to humans. Trends Biochem Sci 32:217-224
5. Garvey M, Gras SL, Meehan S, Meade SJ, Carver JA, Gerrard JA (2009) Protein nano fibres of de fined morphology prepared from mixtures of crude crystallins. Int J Nanotech 6:258-273
6. Gras SL (2007) Amyloid fibrils: From disease to design. New biomaterial applications for self-assembling cross beta- fibrils. Aust J Chem 60:333-342
7. Cherny I, Gazit E (2008) Amyloids: Not only pathological agents but also ordered nanomaterials. Angew Chem Int Ed Engl 47:4062-4069
8. Bloemendal H, de Jong W, Jaenicke R, Lubsen NH, Slingsby C, Tardieu A (2004) Ageing and vision: Structure, stability and function of lens crystallins. Prog Biophys Mol Biol 86:407-485
9. Meehan S, Berry Y, Luisi B, Dobson CM, Carver JA, MacPhee CE (2004) Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation. J Biol Chem 279:3413-3419
10. Meehan S, Knowles TP, Baldwin AJ, Smith JF, Squires AM, Clements P, Treweek TM, Ecroyd H, Tartaglia GG, Vendruscolo M, Macphee CE, Dobson CM, Carver JA (2007) Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins. J Mol Biol 372:470-484
11. Horwitz J, Huang QL, Ding L, Bova MP (1998) Lens alpha-crystallin: Chaperone-like properties. Methods Enzymol 290:365-383
12. Thorn DC, Ecroyd H, Carver JA (2009) The two-faced nature of milk casein proteins: Amyloid fibril formation and chaperone-like activity. Aust J Dairy Technol 64:36-40
13. Thorn DC, Ecroyd H, Sunde M, Poon S, Carver JA (2008) Amyloid fibril formation by bovine milk alphaS2-casein occurs under physiological conditions yet is prevented by its natural counterpart, alphaS1-casein. Biochemistry 47:3926-3936
14. Thorn DC, Meehan S, Sunde M, Rekas A, Gras SL, MacPhee CE, Dobson CM, Wilson MR, Carver JA (2005) Amyloid fibril formation by bovine milk kappa-casein and its inhibition by the molecular chaperones alpha(S)- and beta-casein. Biochemistry 44:17027-17036
15. Morgan PE, Treweek TM, Lindner RA, Price WE, Carver JA (2005) Casein proteins as molecular chaperones. J Agric Food Chem 53:2670-2683
16. Ecroyd H, Thorn DC, Liu Y, Carver JA (2010) The dissociated form of kappa-casein is the precursor to its amyloid fibril formation. Biochem J 429:251-260
17. Ecroyd H, Koudelka T, Thorn DC, Williams DM, Devlin G, Hoffmann P, Carver JA (2008) Dissociation from the oligomeric state is the rate-limiting step in amyloid fibril formation by kappa-casein. J Biol Chem 283: 9012-9022
18. Carver JA, Duggan PJ, Ecroyd H, Liu Y, Meyer AG, Tranberg CE (2010) Carboxymethylated-kappa-casein: A convenient tool for the identi fication of polyphenolic inhibitors of amyloid fibril formation. Bioorg Med Chem 18:222-228