Short report: Mobile phone microscopy for the diagnosis of soil-transmitted helminth infections: A proof-of-concept study

American Journal of Tropical Medicine and Hygiene

Volumn 88, Issue 4, 2013, Pages 626-629

  Bogoch, Isaac I ^a   Andrews, Jason R ^b   Speich, Benjamin ^c,d   Utzinger, Jürg ^c,d   Ame, Shaali M ^e   Ali, Said M ^e   Keiser, Jennifer ^c  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e Public Health Laboratory   (Tanzania)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE;

ARTICLE; ASCARIS LUMBRICOIDES; CAMERA; CHILD; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC LENS AND PRISM; DIAGNOSTIC TEST ACCURACY STUDY; FECES ANALYSIS; HELMINTHIASIS; HOOKWORM; HUMAN; MAJOR CLINICAL STUDY; MICROSCOPE; MICROSCOPY; MOBILE PHONE; MOBILE PHONE MICROSCOPY; NONHUMAN; PARASITE IDENTIFICATION; PARASITE TRANSMISSION; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; TRICHURIS TRICHIURA; ANIMAL; ASCARIASIS; CLINICAL TRIAL; COMPARATIVE STUDY; EQUIPMENT; FECES; HOOKWORM INFECTION; ISOLATION AND PURIFICATION; METHODOLOGY; PARASITOLOGY; REPRODUCIBILITY; SOIL; TRICHURIASIS; TRICHURIS;

ANCYLOSTOMATOIDEA; ANIMALS; ASCARIASIS; ASCARIS LUMBRICOIDES; CELLULAR PHONE; CHILD; FECES; HOOKWORM INFECTIONS; HUMANS; MICROSCOPY; PARASITE EGG COUNT; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOIL; TRICHURIASIS; TRICHURIS;

MLCS; MLOWN;

EID: 84877140764     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.12-0742     Document Type: Article

References (19)

1. Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J, 2008. Helminth infections: the great neglected tropical diseases. J Clin Invest 118: 1311-1321. (Pubitemid 351500423)
2. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ, 2006. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 367: 1521-1532.
3. Knopp S, Steinmann P, Keiser J, Utzinger J, 2012. Nematode infections: soil-transmitted helminths and Trichinella. Infect Dis Clin North Am 26: 341-358.
4. Katz N, Chaves A, Pellegrino J, 1972. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop São Paulo 14: 397-400.
5. Knopp S, Mgeni AF, Khamis IS, Steinmann P, Stothard JR, Rollinson D, Marti H, Utzinger J, 2008. Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques. PLoS Negl Trop Dis 2: e331.
6. Smith ZJ, Chu K, Espenson AR, Rahimzadeh M, Gryshuk A, Molinaro M, Dwyre DM, Lane S, Matthews D, Wachsmann-Hogiu S, 2011. Cell-phone-based platform for biomedical device development and education applications. PLoS One 6: e17150.
7. World Health Organization, 2002. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO expert committee. WHO Tech Rep Ser 912: 1-57.
8. Speich B, Ame SM, Ali SM, Alles R, Hattendorf J, Utzinger J, Albonico M, Keiser J, 2012. Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial. PLoS Negl Trop Dis 6: e1685.
9. Pai NP, Vadnais C, Denkinger C, Engel N, Pai M, 2012. Point-of-care testing for infectious diseases: diversity, complexity, and barriers in low- and middle-income countries. PLoS Med 9: e1001306.
10. Tuijn CJ, Hoefman BJ, van Beijma H, Oskam L, Chevrollier N, 2011. Data and image transfer using mobile phones to strengthen microscopy-based diagnostic services in low and middle income country laboratories. PLoS One 6: e28348.
11. Martin LK, Beaver PC, 1968. Evaluation of Kato thick-smear technique for quantitative diagnosis of helminth infections. Am J Trop Med Hyg 17: 382-391.
12. Keiser J, Utzinger J, 2008. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299: 1937-1948. (Pubitemid 351574924)
13. Hürlimann E, Schur N, Boutsika K, Stensgaard AS, Laserna de Himpsl M, Ziegelbauer K, Laizer N, Camenzind L, Di Pasquale A, Ekpo UF, Simoonga C, Mushinge G, Saarnak CF, Utzinger J, Kristensen TK, Vounatsou P, 2011. Toward an open-access global database for mapping, control, and surveillance of neglected tropical diseases. PLoS Negl Trop Dis 5: e1404.
14. Pullan RL, Brooker SJ, 2012. The global limits and population at risk of soil-transmitted helminth infections in 2010. Parasit Vectors 5: 81.
15. Isikman SO, Greenbaum A, Lee M, Bishara W, Mudanyali O, Su TW, Ozcan A, 2012. Lensfree computational microscopy tools for cell and tissue imaging at the point-of-care and in low-resource settings. Anal Cell Pathol (Amst) 35: 229-247.
16. Lee M, Yaglidere O, Ozcan A, 2011. Field-portable reflection and transmission microscopy based on lensless holography. Biomed Opt Express 2: 2721-2730.
17. Greenbaum A, Sikora U, Ozcan A, 2012. Field-portable wide-field microscopy of dense samples using multi-height pixel super-resolution based lensfree imaging. Lab Chip 12: 1242-1245.
18. Breslauer DN, Maamari RN, Switz NA, Lam WA, Fletcher DA, 2009. Mobile phone based clinical microscopy for global health applications. PLoS One 4: e6320.
19. Linder E, Lundin M, Thors C, Lebbad M, Winiecka-Krusnell J, Helin H, Leiva B, Isola J, Lundin J, 2008. Web-based virtual microscopy for parasitology: a novel tool for education and quality assurance. PLoS Negl Trop Dis 2: e315.