Tea tree oil (5%) body wash versus standard care (johnson's baby softwash) to prevent colonization with methicillin-resistant staphylococcus aureus in critically ill adults: A randomized controlled trial

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 5, 2013, Pages 1193-1199

  Blackwood, Bronagh ^a   Thompson, Gillian ^b   Mcmullan, Ronan ^b   Stevenson, Michael ^a   Riley, Thomas V ^c   Alderdice, Fiona A ^d   Trinder, T John ^e   Lavery, Gavin G ^b   Mcauley, Danny F ^a,b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ROYAL VICTORIA HOSPITAL   (United Kingdom)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^e ULSTER HOSPITAL   (United Kingdom)

Author keywords

Humans; Melaleuca alternifloria; MRSA

Indexed keywords

TEA TREE OIL;

ARTICLE; BACTEREMIA; BACTERIAL COLONIZATION; BACTERIUM; COMPARATIVE STUDY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; HUMAN; INTENSIVE CARE UNIT; IRELAND; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SKIN CARE;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTEREMIA; CARRIER STATE; CRITICAL ILLNESS; DISINFECTANTS; DISINFECTION; FEMALE; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; NORTHERN IRELAND; STAPHYLOCOCCAL INFECTIONS; TEA TREE OIL; TREATMENT OUTCOME;

EID: 84877138959     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks501     Document Type: Article

References (28)

1. Patel M, Weinheimer JD, Waites KB et al. Active surveillance to determine the impact of methicillin-resistant Staphylococcus aureus colonization on patients in intensive care units of a Veterans Affairs Medical Center. Infect Control Hosp Epidemiol 2008; 29: 503-9.
2. Theaker C, Ormonde-Walshe S, Azadian B et al. MRSA in the critically ill. J Hosp Infect 2001; 48: 98-102.
3. Merrer J, Santoli F, Appere de Vecchi C et al. "Colonisation pressure" and risk of acquisition of methicillin-resistant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol 2000; 21: 718-23.
4. Messager S, Hammer KA, Carson CF et al. Assessment of the antibacterial activity of tea tree oil using the European EN1276 and EN12054 standard suspension test. J Hosp Infect 2005; 59: 113-25.
5. Carson CF, Me BJ, Riley TV. Mechanisms of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill lysis, leakage, and salt tolerance assays and electronic microscopy. Antimicrob Agents Chemother 2002; 46: 1914-20.
6. Brady A, Loughlin R, Gilpin D et al. In vitro activity of tea-tree oil against clinical skin isolates of meticillin-resistant and -sensitive Staphylococcus aureus and coagulase-negative staphylococci growing planktonically and as biofilms. J Med Microbiol 2006; 55: 1375-80.
7. Dryden MS, Dailly S, Crouch M. A randomized, controlled trial of tea tree topical preparations versus a standard topical regimen for the clearance of MRSA colonization. J Hosp Infect 2004; 56: 283-6.
8. Caelli M, Porteous J, Carson CF et al. Tea tree oil as an alternative topical decolonisation agent for methicillin-resistant Staphylococcus aureus. J Hosp Infect 2000; 4: 236-7.
9. Holzer M, Cerchari E, Martens P et al. on behalf of the Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. New Engl J Med 2002; 346: 549-56.
10. Finfer S, Bellomo R, Boyce N et al. on behalf of the SAFE Study Investigators. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. New Engl J Med 2004; 350: 2247-56.
11. Harvey S, Harrison DA, Singer M et al. on behalf of the PAC-Man Study Collaboration. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet 2005; 366: 472-7.
12. Thompson G, Blackwood B, McMullan R et al. A randomized controlled trial of tea tree oil (5%) body wash versus JBS to prevent colonization with methicillin-resistant Staphylococcus aureus (MRSA) in critically ill adults: research protocol. BMC Infect Dis 2008; 8: 161.
13. Kwieciński J, Eick S,Wójcik K. Effects of tea tree (Melaleuca alternifolia) oil on Staphylococcus aureus in biofilms and stationary growth phase. Int J Antimicrob Agents 2009; 33: 343-7.
14. May J, Chan CH, King A et al. Time-kill studies of tea tree oils on clinical isolates. J Antimicrob Chemother 2009; 45: 639-43.
15. Bowler WA, Bresnahan J, Bradfish A et al. An integrated approach to methicillin-resistant Staphylococcus aureus control in a rural, regional-referral healthcare setting. Infect Control Hosp Epidemiol 2010; 31: 269-75.
16. Ferreira FL, Bota DP, Bross A et al. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001; 28: 1754-8.
17. Ibelings MMS, Bruining HA. Methicillin-resistant Staphylococcus aureus: acquisition and risk of death in patients in the intensive care unit. Eur J Surg 1998; 164: 411-8.
18. Marshall C, Wolfe R, Kossman T et al. Risk factors for acquisition of methicillin-resistant Staphylococcus aureus (MRSA) by trauma patients in the intensive care unit. J Hosp Infect 2004; 57: 245-52.
19. Thompson DS. Methicillin-resistant Staphylococcus aureus in a general intensive care unit. J R Soc Med 2004; 97: 521-6.
20. Asensio A, Guerrero A, Quereda C et al. Colonisation and infection with methicillin-resistant Staphylococcus aureus: associated factors and eradication. Infect Control Hosp Epidemiol 1996; 17: 20-8.
21. Blot SI, Vandewoude KD, Hoste EA et al. Outcome and attributable mortality in critically ill patients with bacteremia involving methicillinsusceptible and methicillin-resistant Staphylococcus aureus. Arch Intern Med 2002; 162: 2229-35.
22. Lee SC, Chen KS, Tsai CJ et al. An outbreak of methicillin-resistant Staphylococcus aureus infections related to central venous catheters for haemodialysis. Infect Control Hosp Epidemiol 2004; 24: 678-84.
23. Manzur A, Vidal M, Pujol M. Predictive factors of methicillin resistance among patients with Staphylococcus aureus bloodstream infections at hospital admission. J Hosp Infect 2007; 66: 135-41.
24. Pujol M, Pena C, Palares R et al. Risk factors for nosocomial bacteraemia. Eur J Clin Microbiol Infect Dis 1994; 13: 96-102.
25. Williams VR, Callery S, Vearncombe M et al. The role of colonisation pressure in nosocomial transmission of methicillin-resistant Staphylococcus aureus. Am J Infect Control 2009; 37: 106-10.
26. Coia JE, Duckworth GJ, Edwards DI et al. for the Joint Working Party of the British Society of Antimicrobial Chemotherapy, The Hospital Infection Society, and the Infection Control Nurses Association. Guidelines for the control and prevention of methicillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities. J Hosp Infect 2006; 63 Suppl 1: S1-44.
27. Cooper BS, Stone SP, Kibbler C et al. Isolation measures in the hospital management of methicillin resistant Staphylococcus aureus (MRSA): systematic review of the literature. BMJ 2004; 329: 533.
28. Carson CF, Lampacher G, Smith DWet al. Use of deception to achieve double-blinding in a clinical trial of Melaleuca alternifolia (tea tree) oil for the treatment of recurrent herpes labialis. Contemp Clin Trials 2008; 29: 9-12.