1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity

Journal of Biological Inorganic Chemistry

Volumn 17, Issue 8, 2012, Pages 1257-1267

  Zhang, Zhen ^a,b   Bi, Caifeng ^a   Schmitt, Sara M ^b   Fan, Yuhua ^a   Dong, Lili ^a   Zuo, Jian ^a   Dou, Q Ping ^b  

^a Ocean University of China   (China)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

110 Phenanthroline; Apoptosis; Copper; Indole 3 acetic acid; Indole 3 propionic acid

Indexed keywords

1,10 PHENANTHROLINE; ANTINEOPLASTIC METAL COMPLEX; BETA ACTIN; CHYMOTRYPSIN; COPPER; COPPER COMPLEX; DINUCLEAR COPPER COMPLEX; I KAPPA B ALPHA; INDOLEACETIC ACID; INDOLEPROPIONIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEASOME; TERNARY COPPER COMPLEX; UNCLASSIFIED DRUG; 1,10-PHENANTHROLINE; COORDINATION COMPOUND; PHENANTHROLINE DERIVATIVE; PROTEASOME INHIBITOR;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIGAND BINDING; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; PROTEINASE INHIBITION; STRUCTURE ACTIVITY RELATION; TUMOR CELL DESTRUCTION; WESTERN BLOTTING; APOPTOSIS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; FEMALE; NEOPLASM; SYNTHESIS; TUMOR CELL LINE;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; COORDINATION COMPLEXES; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MOLECULAR STRUCTURE; NEOPLASMS; PHENANTHROLINES; PROTEASOME INHIBITORS;

EID: 84877133613     PISSN: 09498257     EISSN: 14321327     Source Type: Journal    
DOI: 10.1007/s00775-012-0940-x     Document Type: Article

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