Regulation of retinal endothelial cell apoptosis through activation of the IGFBP-3 receptor

Apoptosis

Volumn 18, Issue 3, 2013, Pages 361-368

  Zhang, Qiuhua ^a   Soderland, Carl ^b   Steinle, Jena J ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Cell Systems Corporation   (United States)

Author keywords

Apoptosis; IGFBP 3; IGFBP 3 receptor; Retinal endothelial cell

Indexed keywords

CASPASE 3; CONNECTIVE TISSUE GROWTH FACTOR; CYTOCHROME C; GLUCOSE; INSULIN LIKE GROWTH FACTOR BINDING PROTEIN 3 RECEPTOR; PROTEIN BAX; PROTEIN BCL XL; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LYSATE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DNA TRANSFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMMUNOPRECIPITATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; WESTERN BLOTTING;

APOPTOSIS; CELLS, CULTURED; ENDOTHELIAL CELLS; GLUCOSE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; OSMOLAR CONCENTRATION; RECEPTORS, CELL SURFACE; RETINA;

EID: 84877121933     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0793-3     Document Type: Article

References (35)

1. Yamada PM, Lee KW (2009) Perspectives in mammalian IGFBP-3 biology: local vs. systemic action. Am J Physiol Cell Physiol 296:C954-976
2. Firth SM, Baxter RC (2002) Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 23:824-854
3. Perks C, Holly J (2003) Actions of IGFBP on epithelial cancer cells: potential for new therapeutic targets. Horm Metab Res 35:828-835
4. Schedlich LJ, Graham LD, O'Han MK, Muthukaruppan A, Yan X, Firth SM et al (2007) Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: role in modulation of RAR-signaling. Arch Biochem Biophys 465:359-369
5. Lee YC, Jogie-Brahim S, Lee DY, Han J, Harada A, Murphy LJ et al (2011) Insulin-like growth factor-binding protein-3 (IGFBP-3) blocks the effects of asthma by negatively regulating NF-kappaB signaling through IGFBP-3R-mediated activation of caspases. J Biol Chem 286:17898-17909
6. Ikezoe T, Tanosaki S, Krug U, Liu B, Cohen P, Taguchi H et al (2004) Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells. Blood 104:237-242
7. Duschek EJ, de Valk-de Roo GW, Gooren L, Netelenbos C (2004) Effects of conjugated equine estrogen vs. raloxifene on serum insulin-like growth factor-i and insulin-like growth factor binding protein-3: a 2-year, double-blind, placebo-controlled study. Fertil Steril 82:384-390
8. Grimberg A, Coleman CM, Burns TF, Himelstein BP, Koch CJ, Cohen P et al (2005) p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia. J Clin Endocrinol Metab 90:3568-3574
9. Am HZ, Collard TJ, Malik K, Hicks DJ, Paraskeva C, Williams AC (2006) Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells. Int J Oncol 29:1279-1286
10. Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N et al (2007) IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci USA 104:10589-10594
11. Schmid MC, Bisoffi M, Wetterwald A, Gautschi E, Thalmann GN, Mitola S et al (2003) Insulin-like growth factor binding protein-3 is overexpressed in endothelial cells of mouse breast tumor vessels. Int J Cancer 103:577-586
12. Lofqvist C, Willett KL, Aspegren O, Smith AC, Aderman CM, Connor KM et al (2009) Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci 50:1831-1837
13. Janssen JA, Jacobs ML, Derkx FH, Weber RF, van der Lely AJ, Lamberts SW (1997) Free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 (IGFBP-1), and IGFBP-3 and their relationships to the presence of diabetic retinopathy and glomerular hyperfiltration in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 82:2809-2815
14. Regan FM, Williams RM, McDonald A, Umpleby AM, Acerini CL, O'Rahilly S et al (2010) Treatment with recombinant human insulin-like growth factor (rhIGF)-I/rhIGF binding protein-3 complex improves metabolic control in subjects with severe insulin resistance. J Clin Endocrinol Metab 95:2113-2122
15. Zhang Q, Guy K, Pagadala J, Jiang Y, Walker RJ, Liu L et al (2012) Compound 49b prevents diabetes-induced apoptosis through increased IGFBP-3 levels. Invest Ophthalmol Vis Sci 53:3004-3013
16. Kielczewski JL, Hu P, Shaw LC, Li Calzi S, Mames RN, Gardiner TA et al (2011) Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury. Am J Pathol 178:1517-1528
17. Yan X, Forbes BE, McNeil KA, Baxter RC, Firth SM (2004) Role of N- and C-terminal residues of insulin-like growth factor (IGF)-binding protein-3 in regulating IGF complex formation and receptor activation. J Biol Chem 279:53232-53240
18. Oh Y, Muller HL, Pham H, Rosenfeld RG (1993) Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells. J Biol Chem 268:26045-26048
19. Jogie-Brahim S, Feldman D, Oh Y (2009) Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev 30:417-437
20. Leal SM, Liu Q, Huang SS, Huang JS (1997) The type V transforming growth factor beta receptor is the putative insulin-like growth factor-binding protein 3 receptor. J Biol Chem 272:20572-20576
21. Leal SM, Huang SS, Huang JS (1999) Interactions of high affinity insulin-like growth factor-binding proteins with the type V transforming growth factor-beta receptor in mink lung epithelial cells. J Biol Chem 274:6711-6717
22. Huang SS, Leal SM, Chen CL, Liu IH, Huang JS (2004) Identification of insulin receptor substrate proteins as key molecules for the TbetaR-V/LRP-1-mediated growth inhibitory signaling cascade in epithelial and myeloid cells. FASEB J 18:1719-1721
23. Huang SS, Ling TY, Tseng WF, Huang YH, Tang FM, Leal SM et al (2003) Cellular growth inhibition by IGFBP-3 and TGF-beta1 requires LRP-1. FASEB J 17:2068-2081
24. Natsuizaka M, Naganuma S, Kagawa S, Ohashi S, Ahmadi A, Subramanian H et al (2012) Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1alpha-mediated mRNA transcription and continuous protein synthesis. FASEB J 26:2620-2630
25. King JL, Guidry C (2012) Vitreous IGFBP-3 effects on Muller cell proliferation and tractional force generation. Invest Ophthalmol Vis Sci 53:93-99
26. Gribben L, Baxter RC, Marsh DJ (2012) Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells. Cancer Lett 317:41-48
27. Kim JH, Choi DS, Lee OH, Oh SH, Lippman SM, Lee HY (2011) Antiangiogenic antitumor activities of IGFBP-3 are mediated by IGF-independent suppression of Erk1/2 activation and Egr-1-mediated transcriptional events. Blood 118:2622-2631
28. Liu B, Lee HY, Weinzimer SA, Powell DR, Clifford JL, Kurie JM et al (2000) Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis. J Biol Chem 275:33607-33613
29. Liu B, Lee KW, Li H, Ma L, Lin GL, Chandraratna RA et al (2005) Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo. Clin Cancer Res 11:4851-4856
30. Lee KW, Ma L, Yan X, Liu B, Zhang XK, Cohen P (2005) Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. J Biol Chem 280:16942-16948
31. Burrows C, Holly JM, Laurence NJ, Vernon EG, Carter JV, Clark MA et al (2006) Insulin-like growth factor binding protein 3 has opposing actions on malignant and nonmalignant breast epithelial cells that are each reversible and dependent upon cholesterol-stabilized integrin receptor complexes. Endocrinology 147:3484-3500
32. Weinzimer SA, Gibson TB, Collett-Solberg PF, Khare A, Liu B, Cohen P (2001) Transferrin is an insulin-like growth factor-binding protein-3 binding protein. J Clin Endocrinol Metab 86:1806-1813
33. Kuemmerle JF, Murthy KS, Bowers JG (2004) IGFBP-3 activates TGF-beta receptors and directly inhibits growth in human intestinal smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 287:G795-802
34. Ingermann AR, Yang YF, Han J, Mikami A, Garza AE, Mohanraj L et al (2010) Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer. J Biol Chem 285:30233-30246
35. Martinou JC, Youle RJ (2011) Mitochondria in apoptosis: bcl-2 family members and mitochondrial dynamics. Dev Cell 21:92-101