The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro

Molecular and Cellular Endocrinology

Volumn 372, Issue 1-2, 2013, Pages 65-72

  Li, Xun ^a   Su, Juan ^a   Fang, Rui ^a   Zheng, Lucheng ^a   Lei, Ruipeng ^a   Wang, Xiaoye ^a   Lei, Zhihai ^a   Jin, Mengmeng ^a   Jiao, Yang ^a   Hou, Yuanlong ^a   Guo, Tingting ^a   Ma, Zhiyu ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

G protein coupled receptor 147 (GPR147); Gonadotropin inhibitory hormone (GnIH); Hypothalamus pituitary ovary axis; RFamide related peptide 3 (RFRP 3)

Indexed keywords

CYCLIN B1; CYCLINE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 147; GONADORELIN; GONADORELIN RECEPTOR; GONADOTROPIN; GONADOTROPIN INHIBITORY HORMONE; KISSPEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROPEPTIDE; REGULATOR PROTEIN; RFAMIDE RELATED PEPTIDE 3; STEROID HORMONE; UNCLASSIFIED DRUG;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FEMALE GENITAL SYSTEM; GENE EXPRESSION; GRANULOSA CELL; HORMONE RELEASE; HYPOPHYSIS CELL; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IN VITRO STUDY; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STEROID RELEASE; SWINE;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; ESTRADIOL; FEMALE; GENE EXPRESSION; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; GRANULOSA CELLS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; NEUROPEPTIDES; PITUITARY GLAND, ANTERIOR; PROGESTERONE; RECEPTORS, NEUROPEPTIDE; REPRODUCTIVE PHYSIOLOGICAL PROCESSES; SUS SCROFA;

EID: 84877119368     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.03.015     Document Type: Article

References (36)

1. Bentley G.E., Ubuka T., McGuire N.L., Chowdhury V.S., Morita Y., Yano T., Hasunuma I., Binns M., Wingfield J.C., Tsutsui K. Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system. Gen. Comp. Endocr. 2008, 156:34-43.
2. Bentley G.E., Ubuka T., McGuire N.L., Calisi R., Perfito N., Kriegsfeld L.J., Wingfield J.C., Tsutsui K. Gonadotrophin-inhibitory hormone: a multifunctional neuropeptide. J. Neuroendocrinol. 2009, 21:276-281.
3. Bentley G.E., Tsutsui K., Kriegsfeld L.J. Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads. Brain Res. 2010, 1364:62-71.
4. Bogacka I., Siawrys G., Okrasa S., Kaminski T., Przala J. The influences of GnRH, oxytocin and vasoactive intestinal peptide on LH and PRL secretion by porcine pituitary cells in vitro. J. Physiol. Pharmacol. 2002, 53:439-451.
5. Boyadjieva N.I., Sarkar D.K. Role of microglia in ethanol's apoptotic action on hypothalamic neuronal cells in primary cultures. Alcohol. Clin. Exp. Res. 2010, 34:1835-1842.
6. Chaffin C.L., Schwinof K.M., Stouffer R.L. Gonadotropin and steroid control of granulosa cell proliferation during the periovulatory interval in rhesus monkeys. Biol. Reprod. 2001, 65:755-762.
7. Ciccone N.A., Dunn I.C., Boswell T., Tsutsui K., Ubuka T., Ukena K., Sharp P.J. Gonadotrophin inhibitory hormone depresses gonadotrophin alpha and follicle-stimulating hormone beta subunit expression in the pituitary of the domestic chicken. J. Neuroendocrinol. 2004, 16:999-1006.
8. Clarke I.J., Sari I.P., Qi Y., Smith J.T., Parkington H.C., Ubuka T., Iqbal J., Li Q., Tilbrook A., Morgan K., Pawson A.J., Tsutsui K., Millar R.P., Bentley G.E. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology 2008, 149:5811-5821.
9. Hatey F., Langlois I., Mulsant P., Bonnet A., Benne F., Gasser F. Gonadotropins induce accumulation of insulin-like growth factor I mRNA in pig granulosa cells in vitro. Mol. Cell Endocrinol. 1992, 86:205-211.
10. Kadokawa H., Shibata M., Tanaka Y., Kojima T., Matsumoto K., Oshima K., Yamamoto N. Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone (LH) secretion from the pituitary as well as pulsatile LH secretion in bovines. Domest. Anim. Endocrinol. 2009, 36:219-224.
11. Khan A.R., Kauffman A.S. The role of kisspeptin and RFamide-related peptide-3 neurones in the circadian-timed preovulatory luteinising hormone surge. J. Neuroendocrinol. 2012, 24:131-143.
12. Li X., Su J., Lei Z., Zhao Y., Jin M., Fang R., Zheng L., Jiao Y. Gonadotropin-inhibitory hormone (GnIH) and its receptor in the female pig: cDNA cloning, expression in tissues and expression pattern in the reproductive axis during the estrous cycle. Peptides 2012, 36:176-185.
13. Maddineni S., Ocon-Grove O.M., Krzysik-Walker S.M., Hendricks G.L., Proudman J.A., Ramachandran R. Gonadotrophin-inhibitory hormone receptor expression in the chicken pituitary gland: potential influence of sexual maturation and ovarian steroids. J. Neuroendocrinol. 2008, 20:1078-1088.
14. Meloche S., Pouyssegur J. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 2007, 26:3227-3239.
15. Moussavi M., Wlasichuk M., Chang J.P., Habibi H.R. Seasonal effect of GnIH on gonadotrope functions in the pituitary of goldfish. Mol. Cell Endocrinol. 2012, 350:53-60.
16. Oishi H., Klausen C., Bentley G.E., Osugi T., Tsutsui K., Gilks C.B., Yano T., Leung P.C. The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells. Endocrinology 2012, 153:3435-3445.
17. Pineda R., Garcia-Galiano D., Sanchez-Garrido M.A., Romero M., Ruiz-Pino F., Aguilar E., Dijcks F.A., Blomenrohr M., Pinilla L., van Noort P.I., Tena-Sempere M. Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies. Am. J. Physiol. Endocrinol. Metab. 2010, 299:E39-46.
18. Rizwan M.Z., Poling M.C., Corr M., Cornes P.A., Augustine R.A., Quennell J.H., Kauffman A.S., Anderson G.M. RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 2012, 153:3770-3779.
19. Sari I.P., Rao A., Smith J.T., Tilbrook A.J., Clarke I.J. Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology 2009, 150:5549-5556.
20. Sarkar D.K., Boyadjieva N.I., Chen C.P., Ortiguela M., Reuhl K., Clement E.M., Kuhn P., Marano J. Cyclic adenosine monophosphate differentiated beta-endorphin neurons promote immune function and prevent prostate cancer growth. Proc. Natl. Acad. Sci. USA 2008, 105:9105-9110.
21. Seekallu S.V., Toosi B.M., Duggavathi R., Barrett D.M., Davies K.L., Waldner C., Rawlings N.C. Ovarian antral follicular dynamics in sheep revisited: comparison among estrous cycles with three or four follicular waves. Theriogenology 2010, 73:670-680.
22. Seger R., Hanoch T., Rosenberg R., Dantes A., Merz W.E., Strauss J.F., Amsterdam A. The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis. J. Biol. Chem. 2001, 276:13957-13964.
23. Singh P., Krishna A., Sridaran R., Tsutsui K. Changes in GnRH I, bradykinin and their receptors and GnIH in the ovary of Calotes versicolor during reproductive cycle. Gen. Comp. Endocrinol. 2008, 159:158-169.
24. Singh P., Krishna A., Sridaran R., Tsutsui K. Immunohistochemical localization of GnRH and RFamide-related peptide-3 in the ovaries of mice during the estrous cycle. J. Mol. Histol. 2011, 42:371-381.
25. Singh P., Krishna A., Tsutsui K. Effects of gonadotropin-inhibitory hormone on folliculogenesis and steroidogenesis of cyclic mice. Fertil. Steril. 2011, 95:1397-1404.
26. Smith J.T., Shahab M., Pereira A., Pau K.Y., Clarke I.J. Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate. Biol. Reprod. 2010, 83:568-577.
27. Son Y.L., Ubuka T., Millar R.P., Kanasaki H., Tsutsui K. Gonadotropin-inhibitory hormone inhibits GnRH-induced gonadotropin subunit gene transcriptions by inhibiting AC/cAMP/PKA-dependent ERK pathway in LbetaT2 cells. Endocrinology 2012, 153:2332-2343.
28. Szafranska B., Tilton J.E. Free intracellular calcium ([CA2+]i) in opioid sensitive cells of the porcine anterior pituitary. J. Physiol. Pharmacol. 2000, 51:541-554.
29. Tsutsui K., Saigoh E., Ukena K., Teranishi H., Fujisawa Y., Kikuchi M., Ishii S., Sharp P.J. A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem. Biophys. Res. Commun. 2000, 275:661-667.
30. Tsutsui K., Bentley G.E., Kriegsfeld L.J., Osugi T., Seong J.Y., Vaudry H. Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction. J. Neuroendocrinol. 2010, 22:716-727.
31. Tsutsui K., Ubuka T., Bentley G.E., Kriegsfeld L.J. Gonadotropin-inhibitory hormone (GnIH): discovery, progress and prospect. Gen. Comp. Endocrinol. 2012, 177:305-314.
32. Ubuka T., Ukena K., Sharp P.J., Bentley G.E., Tsutsui K. Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail. Endocrinology 2006, 147:1187-1194.
33. Ubuka T., Kim S., Huang Y.C., Reid J., Jiang J., Osugi T., Chowdhury V.S., Tsutsui K., Bentley G.E. Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain. Endocrinology 2008, 149:268-278.
34. Vittoria A., Cocca T., La Mura E., Cecio A. Immunocytochemistry of paraneurons in the female urethra of the horse, cattle, sheep, and pig. Anat. Rec. 1992, 233:18-24.
35. Wu M., Dumalska I., Morozova E., van den Pol A.N., Alreja M. Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism. J. Physiol. 2009, 587:1401-1411.
36. Yin H., Ukena K., Ubuka T., Tsutsui K. A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica): identification, expression and binding activity. J. Endocrinol. 2005, 184:257-266.