Low blood pressure predicts increased mortality in very old age even without heart failure: The Leiden 85-plus Study

European Journal of Heart Failure

Volumn 15, Issue 5, 2013, Pages 528-533

  Poortvliet, Rosalinde K E ^a   Blom, Jeanet W ^a   De Craen, Anton J M ^a   Mooijaart, Simon P ^a,b   Westendorp, Rudi G J ^a,c   Assendelft, Willem J J ^a   Gussekloo, Jacobijn ^a   De Ruijter, Wouter ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Institute for Evidence Based Medicine in Old Age   (Netherlands)

^c Netherlands Consortium for Healthy Ageing   (Netherlands)

Author keywords

Ageing (aged 80 and over); Blood pressure; Heart failure; Mortality

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ANTIHYPERTENSIVE AGENT;

AGE DISTRIBUTION; AGED; ARTICLE; FEMALE; FOLLOW UP; HEART FAILURE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBSERVATIONAL STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RISK FACTOR; SYSTOLIC BLOOD PRESSURE;

AGED, 80 AND OVER; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE; HUMANS; HYPOTENSION; MALE; NATRIURETIC PEPTIDE, BRAIN; NETHERLANDS; PEPTIDE FRAGMENTS; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84877110350     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfs203     Document Type: Article

References (32)

1. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903-1913.
2. Heikinheimo RJ, Haavisto MV, Kaarela RH, Kanto AJ, Koivunen MJ, Rajala SA. Blood pressure in the very old. J Hypertens 1990; 8: 361-367.
3. Molander L, Lovheim H, Norman T, Nordstrom P, Gustafson Y. Lower systolic blood pressure is associated with greater mortality in people aged 85 and older. J Am Geriatr Soc 2008; 56: 1853-1859.
4. van Bemmel T, Gussekloo J, Westendorp RG, Blauw GJ. In a population-based prospective study, no association between high blood pressure and mortality after age 85 years. J Hypertens 2006; 24: 287-292.
5. van Bemmel T, Holman ER, Gussekloo J, Blauw GJ, Bax JJ, Westendorp RG. Low blood pressure in the very old, a consequence of imminent heart failure: the Leiden 85-plus Study. J Hum Hypertens 2009; 23: 27-32.
6. Lernfelt B, Svanborg A. Change in blood pressure in the age interval 70-90. Late blood pressure peak related to longer survival. Blood Press 2002; 11: 206-212.
7. van Hateren KJ, Landman GW, Kleefstra N, Groenier KH, Kamper AM, Houweling ST, Bilo HJ. Lower blood pressure associated with higher mortality in elderly diabetic patients (ZODIAC-12). Age Ageing 2010; 39: 603-609.
8. Himmelmann A. Hypertension: an important precursor of heart failure. Blood Press 1999; 8: 253-260.
9. Oudejans I, Mosterd A, Bloemen JA, Valk MJ, van Velzen E, Wielders JP, Zuithoff NP, Rutten FH, Hoes AW. Clinical evaluation of geriatric outpatients with suspected heart failure: value of symptoms, signs, and additional tests. Eur J Heart Fail 2011; 13: 518-527.
10. Januzzi JL Jr, Chen-Tournoux AA, Moe G. Amino-terminal pro-B-type natriuretic peptide testing for the diagnosis or exclusion of heart failure in patients with acute symptoms. Am J Cardiol 2008; 101: 29-38.
11. Battaglia M, Pewsner D, Juni P, Egger M, Bucher HC, Bachmann LM. Accuracy of B-type natriuretic peptide tests to exclude congestive heart failure: systematic review of test accuracy studies. Arch Intern Med 2006; 166: 1073-1080.
12. Manzano L, Escobar C, Cleland JG, Flather M. Diagnosis of elderly patients with heart failure. Eur J Heart Fail 2012; 14: 1097-1103.
13. Vaes B, Delgado V, Bax J, Degryse J, Westendorp RG, Gussekloo J. Diagnostic accuracy of plasma NT-proBNP levels for excluding cardiac abnormalities in the very elderly. BMC Geriatr 2010; 10: 85.
14. van Exel E, Gussekloo J, Houx P, de Craen AJ, Macfarlane PW, Bootsma-van der Wiel A, Blauw GJ, Westendorp RG. Atherosclerosis and cognitive impairment are linked in the elderly. The Leiden 85-plus Study. Atherosclerosis 2002; 165: 353-359.
15. der Wiel AB, van Exel E, de Craen AJ, Gussekloo J, Lagaay AM, Knook DL, Westendorp RG. A high response is not essential to prevent selection bias: results from the Leiden 85-plus study. J Clin Epidemiol 2002; 55: 1119-1125.
16. Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L, Dumitrascu D, Stoyanovsky V, Antikainen RL, Nikitin Y, Anderson C, Belhani A, Forette F, Rajkumar C, Thijs L, Banya W, Bulpitt CJ. Treatment of hypertension in patients 80 years of age or older. N Engl J Med 2008; 358: 1887-1898.
17. de Ruijter W, Westendorp RG, Macfarlane PW, Jukema JW, Assendelft WJ, Gussekloo J. The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study. J Am Geriatr Soc 2007; 55: 872-877.
18. World Health Organization. International Classification of Diseases and Related Disorders. Geneva: World Health Organization; 2006.
19. Grobbee DE, Hoes AW. Clinical Epidemiology. Principles, Methods, and Applications for Clinical Research. Boston: Jones and Bartlett Publishers; 2009.
20. The NHG-Guideline Working Group. The NHG-Guideline Cardiovascular risk management (first update). Huisarts Wet 2012; 55: 14-28.
21. Whitworth JA. 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 2003; 21: 1983-1992.
22. Galasko GI, Lahiri A, Barnes SC, Collinson P, Senior R. What is the normal range for N-terminal pro-brain natriuretic peptide? How well does this normal range screen for cardiovascular disease? Eur Heart J 2005; 26: 2269-2276.
23. Ueda R, Yokouchi M, Suzuki T, Otomo E, Katagiri T. Prognostic value of high plasma brain natriuretic peptide concentrations in very elderly persons. Am J Med 2003; 114: 266-270.
24. Vaes B, de Ruijter W, Degryse J, Westendorp RG, Gussekloo J. Clinical relevance of a raised plasma N-terminal pro-brain natriuretic peptide level in a populationbased cohort of nonagenarians. J Am Geriatr Soc 2009; 57: 823-829.
25. Wallen T, Landahl S, Hedner T, Nakao K, Saito Y. Brain natriuretic peptide predicts mortality in the elderly. Heart 1997; 77: 264-267.
26. Krumholz HM, Seeman TE, Merrill SS, Mendes de Leon CF, Vaccarino V, Silverman DI, Tsukahara R, Ostfeld AM, Berkman LF. Lack of association between cholesterol and coronary heart disease mortality and morbidity and allcause mortality in persons older than 70 years. JAMA 1994; 272: 1335-1340.
27. Breeze E, Clarke R, Shipley MJ, Marmot MG, Fletcher AE. Cause-specific mortality in old age in relation to body mass index in middle age and in old age: follow-up of the Whitehall cohort of male civil servants. Int J Epidemiol 2006; 35: 169-178.
28. Bos WJ, van Manen JG, Noordzij M, Boeschoten EW, Krediet RT, Dekker FW. Is the inverse relation between blood pressure and mortality normalized in 'low-risk' dialysis patients? J Hypertens 2010; 28: 439-445.
29. Fleischmann E, Teal N, Dudley J, May W, Bower JD, Salahudeen AK. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int 1999; 55: 1560-1567.
30. Curtis JP, Selter JG, Wang Y, Rathore SS, Jovin IS, Jadbabaie F, Kosiborod M, Portnay EL, Sokol SI, Bader F, Krumholz HM. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 2005; 165: 55-61.
31. Marti S, Munoz X, Rios J, Morell F, Ferrer J. Body weight and comorbidity predict mortality in COPD patients treated with oxygen therapy. Eur Respir J 2006; 27: 689-696.
32. Escalante A, Haas RW, del Rincon I. Paradoxical effect of body mass index on survival in rheumatoid arthritis: role of comorbidity and systemic inflammation. Arch Intern Med 2005; 165: 1624-1629.