Insulin-sensitive obese children display a favorable metabolic profile

European Journal of Pediatrics

Volumn 172, Issue 2, 2013, Pages 201-206

  Vukovic, Rade ^a   Mitrovic, Katarina ^a   Milenkovic, Tatjana ^a   Todorovic, Sladjana ^a   Soldatovic, Ivan ^b   Sipetic Grujicic, Sandra ^b   Zdravkovic, Dragan ^a,b  

^a Mother and Child Health Care Institute of Serbia Dr Vukan Cupic   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Children; HOMA IR index; Insulin sensitive obese; Metabolically healthy obese; Obese

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ACTIVITY; CHILD; CHILDHOOD OBESITY; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT TOOL; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTATIC MODEL ASSESSMENT OF INSULIN RESISTANCE INDEX; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLISM; PANCREAS ISLET BETA CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PUBERTY; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; HEALTH STATUS INDICATORS; HUMANS; INSULIN RESISTANCE; MALE; OBESITY;

EID: 84877107603     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-012-1867-5     Document Type: Article

References (33)

1. Alberti K (1999) Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO consultation. Diabetes Med 15:S39-S53
2. Andres R (1980) Effect of obesity on total mortality. Int J Obes 4(4):381-386
3. Arslanian S (2002) Type 2 diabetes in children: clinical aspects and risk factors. Horm Res 57(Suppl 1):19-28
4. Bluher M (2010) The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr Opin Lipidol 21(1):38-43. doi: 10.1097/MOL.0b013e3283346ccc
5. Cali AM, Caprio S (2008) Obesity in children and adolescents. J Clin Endocrinol Metab 93(11 Suppl 1):S31-S36
6. de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J (2007) Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 85(9):660-667
7. Diagnosis and classification of diabetes mellitus (2010) Diabetes Care 33(Suppl 1):S62-S69
8. Fernandez JR, Redden DT, Pietrobelli A, Allison DB (2004) Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents. J Pediatr 145(4):439-444
9. Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G (1997) Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest 100(5):1166-1173
10. Genelhu VA, Celoria BM, Duarte SF, Cabello PH, Francischetti EA (2009) Not all obese subjects of multiethnic origin are at similar risk for developing hypertension and type 2 diabetes. Eur J Intern Med 20(3):289-295
11. Goran MI, Ball GD, Cruz ML (2003) Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. J Clin Endocrinol Metab 88(4):1417-1427
12. Karelis AD (2008) Metabolically healthy but obese individuals. Lancet 372(9646):1281-1283
13. Karelis AD, Rabasa-Lhoret R (2008) Inclusion of C-reactive protein in the identification of metabolically healthy but obese (MHO) individuals. Diabetes Metab 34(2):183-184
14. Karelis AD, St-Pierre DH, Conus F, Rabasa-Lhoret R, Poehlman ET (2004) Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab 89(6):2569-2575
15. Karelis AD, Faraj M, Bastard JP, St-Pierre DH, Brochu M, Prud'homme D, Rabasa-Lhoret R (2005) The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab 90(7):4145-4150
16. Marini MA, Succurro E, Frontoni S, Hribal ML, Andreozzi F, Lauro R, Perticone F, Sesti G (2007) Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women. Diabetes Care 30(8):2145-2147
17. Marshall WA, Tanner JM (1969) Variations in pattern of pubertal changes in girls. Arch Dis Child 44(235):291-303
18. Marshall WA, Tanner JM (1970) Variations in the pattern of pubertal changes in boys. Arch Dis Child 45(239):13-23
19. Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22(9):1462-1470
20. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412-419
21. McLaughlin T, Deng A, Yee G, Lamendola C, Reaven G, Tsao PS, Cushman SW, Sherman A (2010) Inflammation in subcutaneous adipose tissue: relationship to adipose cell size. Diabetologia 53(2):369-377
22. Meigs JB, Wilson PW, Fox CS, Vasan RS, Nathan DM, Sullivan LM, D'Agostino RB (2006) Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 91(8):2906-2912
23. Muniyappa R, Lee S, Chen H, Quon MJ (2008) Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 294(1):E15-E26
24. Pinhas-Hamiel O, Lerner-Geva L, Copperman NM, Jacobson MS (2007) Lipid and insulin levels in obese children: changes with age and puberty. Obesity (Silver Spring) 15(11):2825-2831
25. Primeau V, Coderre L, Karelis AD, Brochu M, Lavoie ME, Messier V, Sladek R, Rabasa-Lhoret R (2011) Characterizing the profile of obese patients who are metabolically healthy. Int J Obes (Lond) 35(7):971-981
26. Sims EA (1981) Mechanisms of hypertension in the syndromes of obesity. Int J Obes 5(suppl 1):9-18
27. Sims EA (2001) Are there persons who are obese, but metabolically healthy? Metabolism 50(12):1499-1504
28. Stefan N, Kantartzis K, Machann J, Schick F, Thamer C, Rittig K, Balletshofer B, Machicao F, Fritsche A, Haring HU (2008) Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168(15):1609-1616
29. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents (2004) Pediatrics 114(2 Suppl):555-576
30. Tsiros MD, Sinn N, Coates AM, Howe PR, Buckley JD (2008) Treatment of adolescent overweight and obesity. Eur J Pediatr 167(1):9-16
31. Weiss R, Taksali SE, Dufour S, Yeckel CW, Papademetris X, Cline G, Tamborlane WV, Dziura J, Shulman GI, Caprio S (2005) The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning. J Clin Endocrinol Metab 90(6):3731-3737
32. World Health Organization (2009) WHO AnthroPlus for personal computers: Software for assessing growth of the world's children and adolescents. http://www.who.int/growthref
33. Zwiauer KF (2000) Prevention and treatment of overweight and obesity in children and adolescents. Eur J Pediatr 159(Suppl 1):S56-S68