Short report: Elevated levels of high-mobility group box-1 (HMGB1) in patients with severe or uncomplicated Plasmodium falciparum malaria

American Journal of Tropical Medicine and Hygiene

Volumn 88, Issue 4, 2013, Pages 733-735

  Angeletti, Davide ^a   Kiwuwa, Mpungu Steven ^b   Byarugaba, Justus ^b   Kironde, Fred ^b   Wahlgren, Mats ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; BIOLOGICAL MARKER; CYTOKINE;

ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; FEVER; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PROTEIN BLOOD LEVEL; SERODIAGNOSIS; ADULT; ANEMIA; BLOOD; CASE CONTROL STUDY; INFANT; INFLAMMATION; MALARIA; PARASITOLOGY; PATHOLOGY; SEVERITY OF ILLNESS INDEX; UGANDA;

ADULT; ANEMIA; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CYTOKINES; HMGB1 PROTEIN; HUMANS; INFANT; INFLAMMATION; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; SEVERITY OF ILLNESS INDEX; UGANDA;

MLCS; MLOWN;

EID: 84877102291     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.12-0530     Document Type: Article

References (25)

1. World Health Organization, 2008. World Malaria Report 2008. Geneva: World Health Organization.
2. Maitland K, Marsh K, 2004. Pathophysiology of severe malaria in children. Acta Trop 90: 131-140. (Pubitemid 38283762)
3. Carlson J, Helmby H, Hill AV, Brewster D, Greenwood BM, Wahlgren M, 1990. Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies. Lancet 336: 1457-1460.
4. Newton CR, Warn PA, Winstanley PA, Peshu N, Snow RW, Pasvol G, Marsh K, 1997. Severe anaemia in children living in amalaria endemic area of Kenya. Trop Med Int Health 2: 165-178. (Pubitemid 27090658)
5. Clark IA, Virelizier JL, Carswell EA, Wood PR, 1981. Possible importance of macrophage-derived mediators in acute malaria. Infect Immun 32: 1058-1066. (Pubitemid 11109808)
6. Kwiatkowski D, Hill AV, Sambou I, Twumasi P, Castracane J, Manogue KR, Cerami A, Brewster DR, Greenwood BM, 1990. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 336: 1201-1204. (Pubitemid 20382913)
7. Ueda T, Yoshida M, 2010. HMGB proteins and transcriptional regulation. Biochim Biophys Acta 1799: 114-118.
8. Harris HE, Andersson U, Pisetsky DS, 2012. HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nature Reviews Rheumatology 8: 195-202.
9. Treutiger CJ, Mullins GE, Johansson AS, Rouhiainen A, Rauvala HM, Erlandsson-Harris H, Andersson U, Yang H, Tracey KJ, Andersson J, Palmblad JE, 2003. High mobility group 1 B-box mediates activation of human endothelium. J Intern Med 254: 375-385. (Pubitemid 37211261)
10. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ, 1999. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285: 248-251. (Pubitemid 29329996)
11. Ito Y, Torii Y, Ohta R, Imai M, Hara S, Kawano Y, Matsubayashi T, Inui A, Yoshikawa T, Nishimura N, Ozaki T, Morishima T, Kimura H, 2011. Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenzainfected children. Cytokine 56: 180-187.
12. Gaini S, Pedersen SS, Koldkjaer OG, Pedersen C, Moller HJ, 2007. High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis: a prospective study. Crit Care 11: R32.
13. Alleva LM, Yang H, Tracey KJ, Clark IA, 2005. High mobility group box 1 (HMGB1) protein: possible amplification signal in the pathogenesis of falciparum malaria. Trans R Soc Trop Med Hyg 99: 171-174. (Pubitemid 40104015)
14. John CC, Opika-Opoka R, Byarugaba J, Idro R, Boivin MJ, 2006. Low levels of RANTES are associated with mortality in children with cerebral malaria. J Infect Dis 194: 837-845. (Pubitemid 44344133)
15. Karlsson S, Pettila V, Tenhunen J, Laru-Sompa R, Hynninen M, Ruokonen E, 2008. HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis. Intensive Care Med 34: 1046-1053. (Pubitemid 351903793)
16. Sunden-Cullberg J, Norrby-Teglund A, Rouhiainen A, Rauvala H, Herman G, Tracey KJ, Lee ML, Andersson J, Tokics L, Treutiger CJ, 2005. Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock. Crit Care Med 33: 564-573. (Pubitemid 40365558)
17. Angus DC, Yang L, Kong L, Kellum JA, Delude RL, Tracey KJ, Weissfeld L, 2007. Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Crit Care Med 35: 1061-1067. (Pubitemid 46598956)
18. Gibot S, Massin F, Cravoisy A, Barraud D, Nace L, Levy B, Bollaert PE, 2007. High-mobility group box 1 protein plasma concentrations during septic shock. Intensive Care Med 33: 1347-1353. (Pubitemid 47101699)
19. Alleva LM, Budd AC, Clark IA, 2008. Systemic release of high mobility group box 1 protein during severe murine influenza. J Immunol 181: 1454-1459.
20. Ling Y, Yang ZY, Yin T, Li L, Yuan WW, Wu HS, Wang CY, 2011. Heparin changes the conformation of high-mobility group protein 1 and decreases its affinity toward receptor for advanced glycation endproducts in vitro. Int Immunopharmacol 11: 187-193.
21. Rao NV, Argyle B, Xu X, Reynolds PR, Walenga JM, Prechel M, Prestwich GD, MacArthur RB, Walters BB, Hoidal JR, Kennedy TP, 2010. Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands. Am J Physiol Cell Physiol 299: C97-C110.
22. Mercereau-Puijalon O, Guillotte M, Vigan-Womas I, 2008. Rosetting in Plasmodium falciparum: a cytoadherence phenotype with multiple actors. Transfus Clin Biol 15: 62-71.
23. Vogt AM, Barragan A, Chen Q, Kironde F, Spillmann D, Wahlgren M, 2003. Heparan sulfate on endothelial cells mediates the binding of Plasmodium falciparum-infected erythrocytes via the DBL1alpha domain of PfEMP1. Blood 101: 2405-2411. (Pubitemid 36302089)
24. Vogt AM, Pettersson F, Moll K, Jonsson C, Normark J, Ribacke U, Egwang TG, Ekre HP, Spillmann D, Chen Q, Wahlgren M, 2006. Release of sequestered malaria parasites upon injection of a glycosaminoglycan. PLoS Pathog 2: e100.
25. Leitgeb AM, Blomqvist K, Cho-Ngwa F, Samje M, Nde P, Titanji V, Wahlgren M, 2011. Low anticoagulant heparin disrupts Plasmodium falciparum rosettes in fresh clinical isolates. Am J Trop Med Hyg 84: 390-396.