Do bupivacaine, clindamycin, and gentamicin at their clinical concentrations enhance rocuronium-induced neuromuscular block?

Korean Journal of Anesthesiology

Volumn 64, Issue 4, 2013, Pages 346-352

  Lee, Soo Il ^a   Lee, Ji Hyeon ^a   Park, Sang Yoong ^a   Park, Jae Won ^a  

^a Dong A University   (South Korea)

Author keywords

Bupivacaine; Clindamycin; Gentamicin; Neuromuscular block; Rocuronium; Therapeutic concentration

Indexed keywords

BUPIVACAINE; CLINDAMYCIN; GENTAMICIN; ROCURONIUM;

ANIMAL TISSUE; ARTICLE; DIAPHRAGM MUSCLE; DRUG CONCENTRATION; HEMIDIAPHRAGM; MALE; NERVE STIMULATION; NEUROMUSCULAR BLOCKING; NONHUMAN; RAT;

EID: 84877095290     PISSN: 20056419     EISSN: 20057563     Source Type: Journal    
DOI: 10.4097/kjae.2013.64.4.346     Document Type: Article

References (30)

1. Kujath P, Bouchard R, Scheele J, Esnaashari H. Current perioperative antibiotic prophylaxis. Chirurg 2006; 77: 490, 492-8.
2. Arias HR, Blanton MP. Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes. Mini Rev Med Chem 2002; 2: 385-410.
3. Prior C, Fiekers JF, Henderson F, Dempster J, Marshall IG, Parsons RL. End-plate ion channel block produced by lincosamide antibiotics and their chemical analogs. J Pharmacol Exp Ther 1990; 255: 1170-6.
4. Singh YN, Marshall IG, Harvey AL. Pre- and postjunctional blocking effects of aminoglycoside, polymyxin, tetracycline and lincosamide antibiotics. Br J Anaesth 1982; 54: 1295-306.
5. Sloan PA, Rasul M. Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium. Anesth Analg 2002; 94: 123-4.
6. Parsons TD, Obaid AL, Salzberg BM. Aminoglycoside antibiotics block voltage-dependent calcium channels in intact vertebrate nerve terminals. J Gen Physiol 1992; 99: 491-504.
7. Lee JH, Lee SI, Lee SC, Choi SR, Rhee WJ. At therapeutic concentration bupivacaine causes neuromuscular blockade and enhances rocuronium-induced blockade. Korean J Anesthesiol 2012; 62: 468- 73.
8. Lee SI, Lee JH, Lee SC, Lee JM, Lee JH. Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations. J Anesth 2008; 22: 385-90.
9. Bruckner J, Thomas KC Jr, Bikhazi GB, Foldes FF. Neuromuscular drug interactions of clinical importance. Anesth Analg 1980; 59: 678-82.
10. Martyn JA. Neuromuscular physiology and pharmacology. In: Miller's Anesthesia. 7th ed. Edited by Miller DR: Philadelphia, Churchill Livingstone Elsevier. 2010, pp 344-53.
11. Bowman WC, Webb SN. Tetanic fade during partial transmission failure produced by non-depolarizing neuromuscular blocking drugs in the cat. Clin Exp Pharmacol Physiol 1976; 3: 545-55.
12. Zucker RS. Calcium and transmitter release. J Physiol Paris 1993; 87: 25-36.
13. Viby-Mogensen J. Neuromuscular monitoring. In: Miller's Anesthesia. 7th ed. Edited by Miller DR: Philadelphia, Churchill Livingstone Elsevier. 2010, pp 1516-7.
14. Elmqvist D, Quastel DM. A quantitative study of end-plate potentials in isolated human muscle. J Physiol 1965; 178: 505-29.
15. Neher E, Steinbach JH. Local anaesthetics transiently block currents through single acetylcholine-receptor channels. J Physiol 1978; 277: 153-76.
16. de Oliveira MJ, Oliveira AC. Mechanisms underlying the vecuronium-induced tetanic fade in the isolated rat muscle. Pharmacol Toxicol 1999; 85: 282-7.
17. Gentry CL, Lukas RJ. Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther 2001; 299: 1038-48.
18. Fujii T, Masai M, Misawa H, Okuda T, Takada-Takatori Y, Moriwaki Y, et al. Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase. J Neurosci Res 2009; 87: 3024-32.
19. Taivainen T, Meretoja OA, Rosenberg PH. The effect of epidural bupivacaine on vecuronium-induced neuromuscular blockade in children. Acta Anaesthesiol Scand 1994; 38: 453-6.
20. al Ahdal O, Bevan DR. Clindamycin-induced neuromuscular blockade. Can J Anaesth 1995; 42: 614-7.
21. Singh YN, Harvey AL, Marshall IG. Antibiotic-induced paralysis of the mouse phrenic nerve-hemidiaphragm preparation, and reversibility by calcium and by neostigmine. Anesthesiology 1978; 48: 418-24.
22. Caputy AJ, Kim YI, Sanders DB. The neuromuscular blocking effects of therapeutic concentrations of various antibiotics on normal rat skeletal muscle: a quantitative comparison. J Pharmacol Exp Ther 1981; 217: 369-78.
23. Dotan ZA, Hana R, Simon D, Geva D, Pfeffermann RA, Ezri T. The effect of vecuronium is enhanced by a large rather than a modest dose of gentamicin as compared with no preoperative gentamicin. Anesth Analg 2003; 96: 750-4.
24. Liu C, Hu F. Investigation on the mechanism of exacerbation of myasthenia gravis by aminoglycoside antibiotics in mouse model. J Huazhong Univ Sci Technolog Med Sci 2005; 25: 294-6.
25. Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 2006; 58: 621-81.
26. Myers DR, DeFehr J, Bennet WM, Porter GA, Olsen GD. Gentamicin binding to serum and plasma proteins. Clin Pharmacol Ther 1978; 23: 356-60.
27. Kays MB, White RL, Gatti G, Gambertoglio JG. Ex vivo protein binding of clindamycin in sera with normal and elevated alpha 1-acid glycoprotein concentrations. Pharmacotherapy 1992; 12: 50-5.
28. Emanuelsson BM, Zaric D, Nydahl PA, Axelsson KH. Pharmacokinetics of ropivacaine and bupivacaine during 21 hours of continuous epidural infusion in healthy male volunteers. Anesth Analg 1995; 81: 1163-8.
29. McKenzie DK, Butler JE, Gandevia SC. Respiratory muscle function and activation in chronic obstructive pulmonary disease. J Appl Physiol 2009; 107: 621-9.
30. Pavlin EG, Holle RH, Schoene RB. Recovery of airway protection compared with ventilation in humans after paralysis with curare. Anesthesiology 1989; 70: 381-5.