Microencapsulation of pancreatic islets for use in a bioartificial pancreas

Methods in Molecular Biology

Volumn 1001, Issue , 2013, Pages 261-266

  Opara, Emmanuel C ^a   McQuilling, John P ^b   Farney, Alan C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Virginia Tech Wake Forest School of Biomedical Engineering and Sciences   (United States)

Author keywords

Alginate; Diabetes; Immunoisolation; Islets; Microencapsulation; Transplantation

Indexed keywords

ARTICLE; BIOARTIFICIAL ORGAN; BIOARTIFICIAL PANCREAS; DIABETIC PATIENT; GRAFT REJECTION; LIQUEFACTION; MICROENCAPSULATION; MOLECULAR WEIGHT; PANCREAS ISLET; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL; STATIC ELECTRICITY;

ALGINATES; ARTIFICIAL ORGANS; BIOPOLYMERS; DRUG COMPOUNDING; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; PANCREAS;

EID: 84877086026     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-363-3_21     Document Type: Article

References (15)

1. Pareta RA, McQuilling JP, Farney A, Opara EC (2012) Bioarti fi cial pancreas: evaluation of crucial barriers to clinical application. In: Organ donation, chapter 14. INTECH Publishers, pp 241-266. ISBN 979-953-307-081-9
2. Soon-Shiong P, Feldman E, Nelson R et al (1992) Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets. Transplantation 54:769-774
3. Cala fi ore R, Calabrese G, Basta G et al (2006) Microencapsulated pancreatic islet allograft into non-immunosuppressed patients with Type 1 diabetes. Diabetes Care 29(1):137-138
4. Elliott RB, Escobar L, Tan PLJ et al (2007) Live encapsulated porcine islets from type 1 diabetic patient 9.5 yr after xenotransplantation. Xenotransplantation 14:157-161
5. http://www.newscientist.com/article/ dn18730-pig-sushi-diabetes-trial- brings-xenotransplant- hope.html
6. Smidsrod O, Skjak-Braek G (1990) Alginate as immobilization matrix for cells. Trends Biotechnol 8:71-78
7. Moya ML, Morley M, Khanna O et al (2012) Stability of alginate microbead properties in vitro. J Mater Sci Mater Med 23:903-912
8. Wolters GH, Fritschy WM, Gerrits D et al (1991) A versatile alginate droplet generator applicable for microencapsulation of pancreatic islets. J Appl Biomater 3:281-286
9. Hongkwan P, Kim PH, Hwang T et al (2012) Fabrication of cross-linked alginate beads using electrospraying for adenovirus delivery. Int J Pharm 427:417-425
10. Gar fi nkel MR, Harland RC, Opara EC (1998) Optimization of the microencapsulated islet for transplantation. J Surg Res 76:7-10
11. Zimmermann U, Mimietz S, Zimmermann H et al (2000) Hydrogel-based non-autologous cell and tissue therapy. Biotechniques 29:564-581
12. Darrabie MD, Kendall WF, Opara EC (2005) Characteristics of poly-L-ornithine-coated alginate microcapsules. Biomaterials 26(34):6846-6852
13. Opara EC, Mirmalek-Sani S-H, Khanna O et al (2010) Design of a bioarti fi cial pancreas. J Investig Med 58(7):831-837
14. Khanna O, Moya ML, Opara EC et al (2010) Synthesis of multi-layered alginate microcapsules for the sustained release of fi broblast growth factor-1. J Biomed Mater Res A 95(2):632-640
15. Tendulkar S, Mirmalek-Sani S-H, Childers C et al (2012) A three-dimensional micro fl uidic approach to scaling up microencapsulation of cells. Biomed Microdevices 14(3):461-469