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Volumn 64, Issue , 2013, Pages 121-128
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In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7- dimethoxyquinazolin-4(3H)-one (RVX-208)
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Author keywords
Biosynthesis; Mass spectrometry; Metabolite identification; Metabolite synthesis
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Indexed keywords
2 ( 4 ( 2 HYDROXYETHOXY) 3,5 DIMETHYLPHENYL) 5,7 DIMETHOXYQUINAZOLIN 4 (3H) ONE;
2 ( 4 ( 5,7 DIMETHOXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL) 2,6 DIMETHYLPHENOXY)ACETIC ACID;
6 ( 2 ( 4 ( 5,7 DIMETHOXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL) 2,6 DIMETHYLPHENOXY)ETHOXY) 3,4,5 TRIHYDROXYTETRAHYDROPYRAN 2 CARBOXYLIC ACID;
ACETIC ACID DERIVATIVE;
CARBOXYLIC ACID;
CARBOXYLIC ACID DERIVATIVE;
GLUCURONIC ACID;
HYDROXYL GROUP;
QUINAZOLINE DERIVATIVE;
RVX 208;
UNCLASSIFIED DRUG;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ARTICLE;
BIOCATALYSIS;
BIOCATALYST;
CELL FRACTIONATION;
CHEMICAL BOND;
CONTROLLED STUDY;
DRUG DETERMINATION;
DRUG GLUCURONIDATION;
DRUG ISOLATION;
DRUG METABOLISM;
DRUG SCREENING;
DRUG SYNTHESIS;
FEMALE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN;
HUMAN CELL;
HUMAN EXPERIMENT;
IN VITRO STUDY;
IN VIVO STUDY;
INCUBATION TIME;
LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY;
LIVER MICROSOME;
MALE;
METABOLITE;
MOUSE;
NONHUMAN;
OXIDATION;
PLASMA;
PROTON NUCLEAR MAGNETIC RESONANCE;
RABBIT;
RAT;
TANDEM MASS SPECTROMETRY;
ANIMALS;
HUMANS;
MICROSOMES, LIVER;
MOLECULAR STRUCTURE;
QUINAZOLINES;
RABBITS;
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EID: 84877085080
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2013.03.062 Document Type: Article |
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Times cited : (19)
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References (7)
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