Influence of HbA1c levels on platelet function profiles associated with tight glycemic control in patients presenting with hyperglycemia and an acute coronary syndrome: A subanalysis of the CHIPS Study ("C ontrol de HI perglucemia y Actividad P laquetaria en Pacientes con S índrome Coronario Agudo")

Journal of Thrombosis and Thrombolysis

Volumn 35, Issue 2, 2013, Pages 165-174

  Vivas, David ^a   García Rubira, Juan C ^a   Bernardo, Esther ^a   Angiolillo, Dominick J ^a   Martín, Patricia ^a   Calle Pascual, Alfonso ^a   Núñez Gil, Iván ^a   MacAya, Carlos ^a   Fernández Ortiz, Antonio ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

Author keywords

Acute coronary syndrome; HbA1c; Platelets

Indexed keywords

FIBRINOGEN RECEPTOR; HEMOGLOBIN A1C; INSULIN; PADGEM PROTEIN;

ACUTE CORONARY SYNDROME; AGED; ARTICLE; BLOOD GLUCOSE MONITORING; CONTROLLED STUDY; FEMALE; GLYCEMIC CONTROL; HEMOGLOBIN DETERMINATION; HUMAN; HYPERGLYCEMIA; INSULIN INFUSION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PLATELET REACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE AGGREGATION;

ACUTE CORONARY SYNDROME; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD GLUCOSE; FEMALE; GLYCEMIC INDEX; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERGLYCEMIA; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; PROSPECTIVE STUDIES;

EID: 84877083549     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-012-0834-3     Document Type: Article

References (32)

1. Norhammar A, Malmberg K, Diderholm E et al (2004) Diabetes mellitus: the major risk factor in unstable coronary artery disease even after consideration of the extent of coronary artery disease and benefits of revascularization. J Am Coll Cardiol 43:585-591
2. Capes SE, Hunt D, Malmberg K et al (2000) Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 355:773-778
3. Vivas D, García-Rubira JC, González-Ferrer JJ et al (2008) Prognostic value of first fasting glucose measurement compared with admission glucose level in patients with acute coronary syndrome. Rev Esp Cardiol 61:458-464
4. Timmer JR, Hoekstra M, Nijsten MW et al (2011) Prognostic value of admission glycosylated hemoglobin and glucose in nondiabetic patients with ST-segment-elevation myocardial infarction treated with percutaneous coronary intervention. Circulation 124:704-711
5. American Diabetes Association (2010) Standards of medical care in diabetes - 2010. Diabetes Care 33(Suppl 1):S11-S61
6. Selvin E, Steffes MW, Zhu H et al (2010) Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med 362:800-811
7. Hadjadj S, Coisne D, Mauco G et al (2004) Prognostic value of admission plasma glucose and HbA in acute myocardial infarction. Diabet Med 21:305-310
8. Angiolillo DJ, Bernardo E, Ramirez C et al (2006) Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment. J Am Coll Cardiol 48:298-304
9. Neubauer H, Setiadi P, Günesdogan B et al (2010) Influence of glycaemic control on platelet bound CD40-CD40L system, P-selectin and soluble CD40 ligand in Type 2 diabetes. Diabet Med 27:384-390
10. Angiolillo DJ, Bernardo E, Sabate M et al (2007) Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol 50:1541-1547
11. Malmberg K, Ryden L, Efendic S et al (1995) Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 26:57-65
12. Malmberg K, Ryden L, Wedel H et al (2005) Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J 26:650-661
13. Wiener RS, Wiener DC, Larson RJ (2008) Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA 300:933-944
14. Finfer S, Chittock DR, Su SY et al (2009) The NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360:1283-1297
15. Vivas D, García-Rubira JC, Bernardo E et al (2011) Effects of intensive glucose control on platelet reactivity in patients with acute coronary syndrome. Results of the CHIPS study. Heart 97:803-809
16. Bassand JP, Hamm CW, Ardissino D et al (2007) Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Task force for diagnosis and treatment of non-ST-segment elevation acute coronary syndromes of European Society of Cardiology. Eur Heart J 28:1598-1660
17. Van de Werf F, Bax J, Betriu A et al (2008) Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology. Eur Heart J 29:2909-2945
18. Rocca B, Santilli F, Pitocco D et al (2012) The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes. J Thromb Haemost 10:1220-1230
19. Angiolillo DJ, Capranzano P, Ferreiro JL et al (2011) Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapy. Thromb Haemost 106:253-262
20. Gurbel PA, Bliden KP, Samara W et al (2005) Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST Study. J Am Coll Cardiol 46:1827-1832
21. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al (2006) Influence of aspirin resistance on platelet function profiles in patients on long-term aspirin and clopidogrel after percutaneous coronary intervention. Am J Cardiol 97:38-43
22. Levey AS, Coresh J, Balk E et al (2003) National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 139:137-147
23. TIMI Study Group. Definitions used in TIMI-trials. http://www.timi.org. Accessed 15 Oct 2011
24. James S, Angiolillo DJ, Cornel JH et al (2010) Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial. Eur Heart J 31:3006-3016
25. Cakmak M, Cakmak N, Cetemen S et al (2008) The value of admission glycosylated haemoglobin level in patients with acute myocardial infarction. Can J Cardiol 24:375-378
26. Cohen HW, Crandall JP, Hailpern SM et al (2008) Aspirin resistance associated with HbA1c and obesity in diabetic patients. J Diabetes Complications 22:224-228
27. Watala C, Golanski J, Pluta J et al (2004) Reduced sensitiviy of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin)-its relation to metabolic control. Thromb Res 113:101-113
28. De Mulder M, Oemrawsingh RM, Stam F et al (2012) Comparison of diagnostic criteria to detect undiagnosed diabetes in hyperglycaemic patients with acute coronary syndrome. Heart 98:37-41
29. Vivas D, Angiolillo DJ (2010) Platelet P2Y12 receptor inhibition: an update on clinical drug development. Am J Cardiovasc Drugs 10:217-226
30. Wiviott SD, Braunwald E, Angiolillo DJ et al (2008) Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38. Circulation 118:1626-1636
31. Angiolillo DJ, Bernardo E, Zanoni M et al (2011) Impact of insulin receptor substrate-1 genotypes on platelet reactivity and cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol 58:30-39
32. Geisler T, Zürn C, Simonenko R et al (2010) Early but not late stent trombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions. Eur Heart J 31:59-66