Low serum total nitrite and nitrate levels in severe leptospirosis

BMC Infectious Diseases

Volumn 13, Issue 1, 2013, Pages

  Kalugalage, Thilini ^a   Rodrigo, Chaturaka ^b   Vithanage, Thamal ^b   Somaratne, Pranitha ^c   De Silva, H Janaka ^d   Handunnetti, Shiroma ^a   Rajapakse, Senaka ^b  

^a UNIVERSITY OF COLOMBO   (Sri Lanka)

^b UNIVERSITY OF COLOMBO   (Sri Lanka)

^c Medical Research Institute Colombo   (Sri Lanka)

^d UNIVERSITY OF KELANIYA   (Sri Lanka)

Author keywords

Creatinine; Leptospirosis; Nitrate; Nitric oxide; Nitrite; Severity

Indexed keywords

CREATININE; NITRATE; NITRIC OXIDE; NITRITE;

ADULT; AGGLUTINATION TEST; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FEVER; HUMAN; KIDNEY FUNCTION; LEPTOSPIROSIS; MAJOR CLINICAL STUDY; MALE; MICROSCOPIC AGGLUTINATION TEST; NITRATE BLOOD LEVEL; NITRITE BLOOD LEVEL; PROGNOSIS;

ADULT; BIOLOGICAL MARKERS; FEMALE; HUMANS; LEPTOSPIROSIS; MALE; MIDDLE AGED; NITRATES; NITRITES; PROGNOSIS; SERUM; SEVERITY OF ILLNESS INDEX; SRI LANKA; YOUNG ADULT;

EID: 84877081206     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-13-206     Document Type: Article

References (29)

1. Cachay ER, Vinetz JM. A global research agenda for leptospirosis. J Postgrad Med 2005, 51(3):174-178. 2270399, 16333188.
2. The Global Burden of Leptospirosis WHO Leptospirosis Burden Epidemiology Reference Group (LERG), http://www.who.int/zoonoses/diseases/lerg/en/index2.html. Accessed October.05.2013.
3. Chawla V, Trivedi TH, Yeolekar ME. Epidemic of leptospirosis: an ICU experience. J Assoc Physicians India 2004, 52:619-622.
4. Abdulkader RC, Silva MV. The kidney in leptospirosis. Pediatr Nephrol 2008, 23(12):2111-2120. 10.1007/s00467-008-0811-4, 18446381.
5. Spichler AS, Vilaca PJ, Athanazio DA, Albuquerque JO, Buzzar M, Castro B, Seguro A, Vinetz JM. Predictors of lethality in severe leptospirosis in urban Brazil. AmJTrop Med Hyg 2008, 79(6):911-914.
6. Rajapakse S, Rodrigo C, Hannifa R. Predictors of mortality in severe leptospirosis; a concept paper on developing a clinically relevant classification. J Emerg Trauma Shock 2010, 3:213-219. 10.4103/0974-2700.66519, 2938484, 20930963.
7. Davis JS, Anstey NM. Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis. Crit Care Med 2011, 39(2):380-385. 10.1097/CCM.0b013e3181ffd9f7, 21150584.
8. Prada J, Kremsner PG. Enhanced production of reactive nitrogen intermediates in human and murine malaria. Parasitol Today 1995, 11(11):409-410. 10.1016/0169-4758(95)80019-0, 15275387.
9. Kremsner PG, Winkler S, Wildling E, Prada J, Bienzle U, Graninger W, Nussler AK. High plasma levels of nitrogen oxides are associated with severe disease and correlate with rapid parasitological and clinical cure in Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 1996, 90(1):44-47. 10.1016/S0035-9203(96)90476-9, 8730311.
10. Al Yaman FM, Mokela D, Genton B, Rockett KA, Alpers MP, Clark IA. Association between serum levels of reactive nitrogen intermediates and coma in children with cerebral malaria in Papua New Guinea. Trans R Soc Trop Med Hyg 1996, 90(3):270-273. 10.1016/S0035-9203(96)90243-6, 8758073.
11. Anstey NM, Weinberg JB, Hassanali MY, Mwaikambo ED, Manyenga D, Misukonis MA, Arnelle DR, Hollis D, McDonald MI, Granger DL. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med 1996, 184(2):557-567. 10.1084/jem.184.2.557, 2192721, 8760809.
12. Prada J, Kremsner PG. Reactive nitrogen intermediates and cerebral malaria. Trans R Soc Trop Med Hyg 1997, 91(1):92-93.
13. Anstey NM, Granger DL, Weinberg JB. Nitrate levels in malaria. Trans R Soc Trop Med Hyg 1997, 91(2):238-240. 10.1016/S0035-9203(97)90237-6, 9196781.
14. Maciel EA, Athanazio DA, Reis EA, Cunha FQ, Queiroz A, Almeida D, McBride AJ, Ko AI, Reis MG. High serum nitric oxide levels in patients with severe leptospirosis. Acta Trop 2006, 100(3):256-260. 10.1016/j.actatropica.2006.11.006, 1805659, 17196920.
15. Moshage H, Kok B, Huizenga JR, Jansen PLM. Nitrite and nitrate determinations in plasma: A critical evaluation. Clin Chem 1995, 41:892-896.
16. Groeneveld PHP, Kwappenberg KMC, Langermans JAM, Nibbering PH, Curtis L. Relation between pro-and anti-inflammatory cytokines and the production of nitric oxide (NO) in severe sepsis. Cytokine 1997, 9:138-142. 10.1006/cyto.1996.0147, 9071565.
17. Granger DL, Anstey NM, Miller WC, Weinberg JB. Measuring nitric oxide production in human clinical studies. Methods Enzymol 1999, 301:49-61.
18. Mackenzie IM, Ekangaki A, Young JD, Garrard CS. Effect of renal function on serum nitrogen oxide concentrations. Clin Chem 1996, 42(3):440-444.
19. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007, 11(2):R31. 10.1186/cc5713, 2206446, 17331245.
20. Gunaratna RI, Handunnetti SM, Bulathsinghalage MR, Somaratne P, Jayanaga A, de Silva HJ, Rajapakse S. Serum nitrite levels in Sri Lankan patients with leptospirosis. Asian Pac J Trop Med 2012, 5:75-78. 10.1016/S1995-7645(11)60250-2, 22182649.
21. An interim analysis of Leptospirosis outbreak in Sri Lanka-2008. Colombo: Epidemiology Unit, Ministry of Health Care and Nutrition, Sri Lanka; 2008.
22. World Health Organization Human Leptospirosis. Guidance for diagnosis surveillance and control 2003, Geneva: World Health Organization, World Health Organization.
23. Cumberland P, Everard CO, Levett PN. Assessment of the efficacy of an IgM-elisa and microscopic agglutination test (MAT) in the diagnosis of acute leptospirosis. Am J Trop Med Hyg 1999, 61(5):731-734.
24. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001, 5:62-71. 10.1006/niox.2000.0319, 11178938.
25. Ghasemi A, Hedayati M, Biabani H. Protien precipitation methods evaluated for determination of serum nitric oxide end products by the Griess assay. Journal of Medical Science Research 2007, 2:29-32.
26. Gramaglia I, Sobolewski P, Meays D, Contreras R, Nolan JP, Frangos JA, Intaglietta M, van der Heyde HC. Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med 2006, 12(12):1417-1422.
27. Toprakçi M, Ozmen D, Mutaf I, Turgan N, Parildar Z, Habif S, Güner I, Bayindir O. Age-associated changes in nitric oxide metabolites nitrite and nitrate. Int J Clin Lab Res 2000, 30:83-85.
28. Levett PN. Leptospirosis. Clin Microbiol Rev 2001, 14(2):296-326. 10.1128/CMR.14.2.296-326.2001, 88975, 11292640.
29. Levett PN, Branch SL, Whittington CU, Edwards CN, Paxton H. Two methods for rapid serological diagnosis of acute leptospirosis. Clin Diagn Lab Immunol 2001, 8(2):349-351. 96061, 11238220.