Animal models of osteoarthritis: Challenges of model selection and analysis

AAPS Journal

Volumn 15, Issue 2, 2013, Pages 438-446

  Teeple, Erin ^a   Jay, Gregory D ^a,b   Elsaid, Khaled A ^c   Fleming, Braden C ^a  

^a RHODE ISLAND HOSPITAL   (United States)

^b Brown University   (United States)

^c MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

animal; model; osteoarthritis

Indexed keywords

PROTEOGLYCAN;

ALLODYNIA; ANIMAL MODEL; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; ARTHROSCOPY; BIOMECHANICS; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; DISEASE MODEL; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; EXERCISE INTENSITY; GAIT; INFLAMMATION; JOINT DEGENERATION; JOINT FUNCTION; JOINT STABILITY; MATHEMATICAL ANALYSIS; MENISCECTOMY; MOLECULAR DYNAMICS; MORPHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOARTHRITIS; PAIN; PATHOPHYSIOLOGY; REVIEW; SYMPTOMATOLOGY; SYNOVITIS; VALIDATION PROCESS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRALGIA; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GAIT; JOINTS; OSTEOARTHRITIS; PAIN MEASUREMENT; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REPRODUCIBILITY OF RESULTS; SEVERITY OF ILLNESS INDEX; SPECIES SPECIFICITY; TIME FACTORS;

EID: 84877078308     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-013-9454-x     Document Type: Review

References (51)

1. Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011;23(5):471-8. PubMed PMID: 21788902. Epub 2011/07/27. eng.
2. Adatia A, Rainsford KD, Kean WF. Osteoarthritis of the knee and hip. Part I: Aetiology and pathogenesis as a basis for pharmacotherapy. J Pharm Pharmacol. 2012;64(5):617-25.
3. Iannone F, Lapadula G. Obesity and inflammation - targets for OA therapy. Curr Drug Targets. 2010;11(5):586-98.
4. Goldring MB, Marcu KB. Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther. 2009;11(3):224. PubMed PMID: 19519926. Pubmed Central PMCID: 2714092.
5. Loeser RF. Aging and osteoarthritis: The role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage. 2009;17(8):971-9. PubMed PMID: 19303469. Pubmed Central PMCID: 2713363.
6. OAC Histopathology Supplement. In: Aigner T, Lohmander, S, editors. Osteoarthritis and cartilage/OARS, Osteoarthritis Research Society; 2010.
7. Fleming BC, Machan MT, Shalvoy MT, Murray MM. A collagen platelet composite to stimulate healing after ACL surgery also minimizes cartilage damage in the ACL injured knee. Osteoarthritis Cartilage. 2012;20 (Supplement 1)(S68).
8. Murray MM, Magarian EM, Harrison SL, Mastrangelo AN, Zurakowski D, Fleming BC. The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg Am. 2010;92(11):2039-49. PubMed PMID: 20810854. Pubmed Central PMCID: 2924734. Epub 2010/09/03. eng.
9. Chu CR, Szczodry M, Bruno S. Animal models for cartilage regeneration and repair. Tissue Eng Part B Rev. 2010;16(1):105-15. PubMed PMID: 19831641. Pubmed Central PMCID: 3121784. Epub 2009/10/17. eng.
10. Proffen BL, McElfresh M, Fleming BC, Murray MM. A comparative anatomical study of the human knee and six animal species. Knee. 2012;19(4):493-9. PubMed PMID: 21852139. Pubmed Central PMCID: 3236814. Epub 2011/08/20. eng.
11. Murray MM, Fleming BC. Use of a Bioactive Scaffold to Stimulate ACL Healing also Minimizes Post-traumatic Osteoarthritis After Surgery. Trans Orthop Res Soc. 2013;38:51
12. Muir P, Schwartz Z, Malek S, Kreines A, Cabrera SY, Buote NJ, et al. Contralateral cruciate survival in dogs with unilateral non-contact cranial cruciate ligament rupture. PLoS One. 2011;6(10):e25331. PubMed PMID: 21998650. Pubmed Central PMCID: 3187768.
13. Bendele AM. Animal models of osteoarthritis. J Musculoskelet Neuronal Interact. 2001;1(4):363-76. PubMed PMID: 15758487. Epub 2005/03/11. eng.
14. Janusz MJ, Bendele AM, Brown KK, Taiwo YO, Hsieh L, Heitmeyer SA. Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor. Osteoarthritis Cartilage. 2002;10(10):785-91.
15. Englund M, Guermazi A, Roemer FW, Aliabadi P, Yang M, Lewis CE, et al. Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study. Arthritis Rheum. 2009;60(3):831-9. PubMed PMID: 19248082. Pubmed Central PMCID.
16. Karahan S, Kincaid SA, Kammermann JR, Wright JC. Evaluation of the rat stifle joint after transection of the cranial cruciate ligament and partial medial meniscectomy. Comp Med. 2001;51(6):504-12. PubMed PMID: 11924812. Epub 2002/04/02. eng.
17. Messner K, Gao J. The menisci of the knee joint. Anatomical and functional characteristics, and a rationale for clinical treatment. J Anat. 1998;193(Pt 2):161-78. PubMed PMID: 9827632. Pubmed Central PMCID: 1467836. Epub 1998/11/25. eng.
18. Seitz AM, Lubomierski A, Friemert B, Ignatius A, Durselen L. Effect of partial meniscectomy at the medial posterior horn on tibiofemoral contact mechanics and meniscal hoop strains in human knees. J Orthop Res. 2012;30(6):934-42. PubMed PMID: 22072570. Epub 2011/11/11. eng.
19. Moody HR, Heard BJ, Frank CB, Shrive NG, Oloyede AO. Investigating the potential value of individual parameters of histological grading systems in a sheep model of cartilage damage: The modified Mankin method. J Anat. 2012;221(1):47-54. PubMed PMID: 22591160. Epub 2012/05/18. eng.
20. Barve RA, Minnerly JC, Weiss DJ, Meyer DM, Aguiar DJ, Sullivan PM, et al. Transcriptional profiling and pathway analysis of monosodium iodoacetate-induced experimental osteoarthritis in rats: Relevance to human disease. Osteoarthritis Cartilage. 2007;15(10):1190-8. PubMed PMID: 17500014. Epub 2007/05/15. eng.
21. Galois L, Etienne S, Grossin L, Watrin-Pinzano A, Cournil-Henrionnet C, Loeuille D, et al. Dose-response relationship for exercise on severity of experimental osteoarthritis in rats: A pilot study. Osteoarthritis Cartilage. 2004;12(10):779-86. PubMed PMID: 15450527. Epub 2004/09/29. eng.
22. Appleton CT, McErlain DD, Pitelka V, Schwartz N, Bernier SM, Henry JL, et al. Forced mobilization accelerates pathogenesis: Characterization of a preclinical surgical model of osteoarthritis. Arthritis Res Ther. 2007;9(1):R13. PubMed PMID: 17284317. Pubmed Central PMCID: 1860072. Epub 2007/02/08. eng.
23. Elsaid KA, Zhang L, Waller K, Tofte J, Teeple E, Fleming BC, et al. The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection. Osteoarthritis Cartilage. 2012;20(8):940-8. PubMed PMID: 22579916. Epub 2012/05/15. Eng.
24. Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. 2012;64(4):455-74. PubMed PMID: 22563589. Epub 2012/05/09. eng.
25. Issa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: Integrating biomechanics and inflammation. Pathobiology Aging Age Relat Dis. 2012;2(2012). pii: 17470. PubMed PMID: 22662293. Pubmed Central PMCID: 3364606. Epub 2012/06/05. Eng.
26. Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, et al. Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther. 2010;12(4):R130. PubMed PMID: 20604941. Pubmed Central PMCID: 2945020. Epub 2010/07/08. eng.
27. Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F. Diet-induced obesity significantly increases the severity of post-traumatic arthritis in mice. Arthritis Rheum. 2012;64(10): 3220-30. PubMed PMID: 22576842. Epub 2012/05/12. Eng.
28. Griffin TM, Guilak F. Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology. 2008;45(3-4):387-98. PubMed PMID: 18836239. Pubmed Central PMCID: 2748656. Epub 2008/10/07. eng.
29. Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F. Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: Effects of short-term exercise. Arthritis Rheum. 2012;64(2):443-53. PubMed PMID: 21953366. Pubmed Central PMCID: 3268860. Epub 2011/09/29. eng.
30. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494-502. PubMed PMID: 13498604. Pubmed Central PMCID: 1006995. Epub 1957/12/01. eng.
31. McErlain DD, Ulici V, Darling M, Gati JS, Pitelka V, Beier F, et al. An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis. Arthritis Res Ther. 2012;14(1):R26. PubMed PMID: 22304985. Epub 2012/02/07. Eng.
32. Fenty MC, Dodge GR, Kassey VB, Witschey WR, Borthakur A, Reddy R. Quantitative cartilage degeneration associated with spontaneous osteoarthritis in a guinea pig model. J Magn Reson Imaging. 2012;35(4):891-8. PubMed PMID: 22128105. Pubmed Central PMCID: 3292653. Epub 2011/12/01. eng.
33. Chan DD, Neu CP. Probing articular cartilage damage and disease by quantitative magnetic resonance imaging. J R Soc Interface. 2013;10(78): 20120608. PubMed PMID: 23135247.
34. Hunter DJ, Zhang W, Conaghan PG, Hirko K, Menashe L, Li L, et al. Systematic review of the concurrent and predictive validity of MRI biomarkers in OA. Osteoarthritis Cartilage. 2011;19(5):557-88. PubMed PMID: 21396463. Pubmed Central PMCID: 3268360.
35. Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, et al. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage. 2011;19(5):515-42. PubMed PMID: 21396468. Epub 2011/03/15. eng.
36. Bauer DC, Hunter DJ, Abramson SB, Attur M, Corr M, Felson D, et al. Classification of osteoarthritis biomarkers: A proposed approach. Osteoarthritis Cartilage. 2006;14(8):723-7. PubMed PMID: 16733093. Epub 2006/05/31. eng.
37. Kraus VB, Huebner JL, Fink C, King JB, Brown S, Vail TP, et al. Urea as a passive transport marker for arthritis biomarker studies. Arthritis Rheum. 2002;46(2):420-7. PubMed PMID: 11840444. Epub 2002/02/13. eng.
38. Seifer DR, Furman BD, Guilak F, Olson SA, Brooks 3rd SC, Kraus VB. Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice. Osteoarthritis Cartilage. 2008;16(12):1532-8. PubMed PMID: 18538588. Pubmed Central PMCID: 2602808. Epub 2008/06/10. eng.
39. Little CB, Zaki S. What constitutes an "animal model of osteoarthritis" - the need for consensus? Osteoarthritis Cartilage. 2012;20(4):261-7. PubMed PMID: 22321719. Epub 2012/02/11. eng.
40. Neugebauer V, Han JS, Adwanikar H, Fu Y, Ji G. Techniques for assessing knee joint pain in arthritis. Mol Pain. 2007;3(8). PubMed PMID: 17391515. Pubmed Central PMCID: 1851005. Epub 2007/03/30. eng.
41. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53(1):55-63. PubMed PMID: 7990513. Epub 1994/07/01. eng.
42. Allen KD, Mata BA, Gabr MA, Huebner JL, Adams Jr SB, Kraus VB, et al. Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis. Arthritis Res Ther. 2012;14(2):R78. PubMed PMID: 22510443. Epub 2012/04/19. Eng.
43. Bove SE, Laemont KD, Brooker RM, Osborn MN, Sanchez BM, Guzman RE, et al. Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia. Osteoarthritis Cartilage. 2006;14(10):1041-8. PubMed PMID: 16769229. Epub 2006/06/14. eng.
44. Fernihough J, Gentry C, Malcangio M, Fox A, Rediske J, Pellas T, et al. Pain related behaviour in two models of osteoarthritis in the rat knee. Pain. 2004;11(1-2):83-93. PubMed PMID: 15494188. Epub 2004/10/21. eng.
45. Bove SE, Calcaterra SL, Brooker RM, Huber CM, Guzman RE, Juneau PL, et al. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthritis Cartilage. 2003;11(11):821-30. PubMed PMID: 14609535. Epub 2003/11/12. eng.
46. Jay GD, Elsaid KA, Kelly KA, Anderson SC, Zhang L, Teeple E, et al. Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum. 2012;64(4):1162-71. PubMed PMID: 22127873. Pubmed Central PMCID: 3297696. Epub 2011/12/01. eng.
47. Boettger MK, Leuchtweis J, Schaible HG, Schmidt M. Videoradiographic analysis of the range of motion in unilateral experimental knee joint arthritis in rats. Arthritis Res Ther. 2011;13(3):R79. PubMed PMID: 21619620. Pubmed Central PMCID: 3218889. Epub 2011/05/31. eng.
48. Boettger MK, Weber K, Schmidt M, Gajda M, Brauer R, Schaible HG. Gait abnormalities differentially indicate pain or structural joint damage in monoarticular antigen-induced arthritis. Pain. 2009;145(1-2):142-50. PubMed PMID: 19570610. Epub 2009/07/03. eng.
49. Malek S, Sample SJ, Schwartz Z, Nemke B, Jacobson PB, Cozzi EM, et al. Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis. BMC Vet Res. 2012;8(1):185. PubMed PMID: 23035739.
50. Ishihara A, Bertone AL, Rajala-Schultz PJ. Association between subjective lameness grade and kinetic gait parameters in horses with experimentally induced forelimb lameness. Am J Vet Res. 2005;66(10):1805-15.
51. Frank CB, Beveridge JE, Huebner KD, Heard BJ, Tapper JE, O'Brien EJ, et al. Complete ACL/MCL deficiency induces variable degrees of instability in sheep with specific kinematic abnormalities correlating with degrees of early osteoarthritis. J Orthop Res. 2012;30(3):384-92. PubMed PMID: 21919045. Epub 2011/09/16. eng.