Mortality in Clostridium difficile infection: A prospective analysis of risk predictors

European Journal of Gastroenterology and Hepatology

Volumn 25, Issue 6, 2013, Pages 700-705

  Bloomfield, Maxim G ^a,b   Carmichael, Andrew J ^c   Gkrania Klotsas, Effrossyni ^c  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Clostridium difficile; mortality; pseudomembranous colitis; risk prediction; severity

Indexed keywords

C REACTIVE PROTEIN; CREATININE; SERUM ALBUMIN;

ADULT; AGED; ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; CREATININE BLOOD LEVEL; FEMALE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; ENGLAND; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FEMALE; HOSPITAL MORTALITY; HUMANS; KAPLAN-MEIER ESTIMATE; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SERUM ALBUMIN;

EID: 84877077779     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32835ed64d     Document Type: Article

References (20)

1. Kuijper EJ, Coignard B, Tu ll P. Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect 2006; 12 (Suppl 6):2-18.
2. Kelly CP, LaMont JT. Clostridium difficile-more difficult than ever. N Engl J Med 2008; 359:1932-1940.
3. Pe pin J, Valiquette L, Alary M, Villemure P, Pelletier A, Forget K, Pepin K, Chouinard D, et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004; 171:466-472.
4. Rupnik M, Wilcox MH, Gerding DN. Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 2009; 7:526-536.
5. Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud S, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficileassociated diarrhea with high morbidity and mortality. N Engl J Med 2005; 353:2442-2449.
6. Karas JA, Enoch DA, Aliyu SH. A review of mortality due to Clostridium difficile infection. J Infect 2010; 61:1-8.
7. Zar FA, Bakkanagari SR, KMLST Moorthi, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficileassociated diarrhea, stratified by disease severity. Clin Infect Dis 2007; 45:302-307.
8. Gerding DN, Johnson S. Management of Clostridium difficile infection: thinking inside and outside the box. Clin Infect Dis 2010; 51:1306-1313.
9. Bloomfield MG, Sherwin JC, Gkrania-Klotsas E. Risk factors for mortality in Clostridium difficile infection in the general hospital population: a systematic review. J Hosp Infect 2012; 82:1-12.
10. Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, et al. Updating and validating the charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol 2011; 173:676-682.
11. Wilson V, Cheek L, Satta G, Walker-Bone K, Cubbon M, Citron D, et al. Predictors of death after Clostridium difficile infection: a report on 128 strain-typed cases from a teaching hospital in the United Kingdom. Clin Infect Dis 2010; 50:e77-e81.
12. Royston P, Sauerbrei W. A new measure of prognostic separation in survival data. Stat Med 2004; 23:723-748.
13. Khanna S, Aronson SL, Kammer PP, Baddour LM, Pardi DS. Gastric acid suppression and outcomes in Clostridium difficile infection: a populationbased study. Mayo Clin Proc 2012; 87:636-642.
14. Wilcox M, Eastwood K. Evaluation report: Clostridium difficile toxin detection assays. London: Centre for Evidence-based Purchasing, Policy and Innovation Directorate, NHS Purchasing and Suppy Agency; 2009.
15. Coia J, Jones B, Lockhart M, Pankhania H, Eastaway A. Recommended protocol for testing for Clostridium difficile and subsequent culture. Scottish Salmonella, Shigella, Clostridium difficile Reference laboratory, 2009.
16. Hessen MT. In the clinic. Clostridium difficile infection. Ann Intern Med 2010; 153:ITC2-ITC15.
17. Hardt C, Berns T, Treder W, Dumoulin F-L. Univariate and multivariate analysis of risk factors for severe Clostridium difficile-associated diarrhoea: importance of co-morbidity and serum C-reactive protein. World J Gastroenterol 2008; 14:4338-4341.
18. Hu MY, Katchar K, Kyne L, Maroo S, Tummala S, Dreisbach V, et al. Prospective derivation and validation of a clinical prediction rule for recurrent Clostridium difficile infection. Gastroenterology 2009; 136:1206-1214.
19. HPA. HPA-mandatory surveillance of Clostridium difficile. London, UK: Health Protection Agency 2011; Available at: http://www.hpa.org.uk/Topics/ InfectiousDiseases/InfectionsAZ/ClostridiumDifficile/EpidemiologicalData/ MandatorySurveillance/[Accessed 2 July 2011].
20. Healthcare Commission. Investigation into outbreaks of Clostridium difficile at Maidstone and Tunbridge Wells NHS Trust. London: Healthcare Commission; 2007.