Impact of high salt independent of blood pressure on PRMT/ADMA/DDAH pathway in the aorta of dahl salt-sensitive rats

International Journal of Molecular Sciences

Volumn 14, Issue 4, 2013, Pages 8062-8072

  Cao, Yu ^a   Mu, Jian Jun ^a   Fang, Yuan ^a   Yuan, Zu Yi ^a   Liu, Fu Qiang ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Asymmetric dimethylarginine; Dimethylaminohydrolase; Dimethylarginine; Endothelial dysfunction; Endothelial nitrite oxide synthase; Oxidative stress

Indexed keywords

DIMETHYLARGININASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PROTEIN ARGININE METHYLTRANSFERASE; AMIDASE; ANTIHYPERTENSIVE AGENT; ARGININE; HYDRALAZINE; MESSENGER RNA; N,N-DIMETHYLARGININE; NITRIC OXIDE; NOS3 PROTEIN, RAT; PRMT1 PROTEIN, RAT; SALT INTAKE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; MALE; METABOLIC REGULATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN METABOLISM; RAT; SALT INTAKE; SIGNAL TRANSDUCTION; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; AORTA; BLOOD; DAHL RAT; DRUG EFFECTS; GENETICS; HYPERTENSION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

RATTUS;

AMIDOHYDROLASES; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA; ARGININE; BLOOD PRESSURE; HYDRALAZINE; HYPERTENSION; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN-ARGININE N-METHYLTRANSFERASES; RATS; RATS, INBRED DAHL; RNA, MESSENGER; SIGNAL TRANSDUCTION; SODIUM CHLORIDE, DIETARY;

EID: 84877075246     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14048062     Document Type: Article

References (35)

1. Miyoshi, A.; Suzuki, H.; Fujiwara, M.; Masai, M.; Iwasaki, T. Impairment of endothelial function in salt-sensitive hypertension in humans. Am. J. Hypertens. 1997, 10, 1083-1090.
2. Vanhoutte, P.M. Endothelium and control of vascular function. State of the Art lecture. Hypertension 1989, 13, 658-667.
3. Lüscher, T. Imbalance of endothelium-derived relaxing and contracting factors. A new concept in hypertension? Am. J. Hypertens. 1990, 3, 317-330.
4. Bermudez, V.; Bermudez, F.; Acosta, G.; Acosta, A.; Anez, J.; Andara, C.; Leal, E.; Cano, C.; Manuel, V.; Hernández, R. Molecular mechanisms of endothelial dysfunction: From nitric oxide synthesis to ADMA inhibition. Am. J. Ther. 2008, 15, 326-333.
5. Bragulat, E.; Sierra, A. Salt intake, endothelial dysfunction, and salt-sensitive hypertension. J. Clin. Hypertens. 2007, 4, 41-46.
6. Toda, N.; Arakawa, K. Salt-induced hemodynamic regulation mediated by nitric oxide. J. Hypertens. 2011, 29, 415-424.
7. Schmidlin, O.; Forman, A.; Leone, A.; Sebastian, A.; Morris, R.C., Jr. Salt sensitivity in blacks evidence that the initial pressor effect of NaCl involves inhibition of vasodilatation by asymmetrical dimethylarginine. Hypertension 2011, 58, 380-385.
8. Vallance, P.; Leiper, J. Cardiovascular biology of the asymmetric dimethylarginine: Dimethylarginine dimethylaminohydrolase pathway. Arterioscl. Thromb. Vasc. Biol. 2004, 24, 1023-1030.
9. Bedford, M.T.; Clarke, S.G. Protein arginine methylation in mammals: Who, what, and why. Mol. Cell 2009, 33, 1-13.
10. Tojo, A.; Kimoto, M.; Wilcox, C.S. Renal expression of constitutive NOS and DDAH: Separate effects of salt intake and angiotensin. Kidney Int. 2000, 58, 2075-2083.
11. Tojo, A.; Welch, W.J.; Bremer, V.; Kimoto, M.; Kimura, K.; Omata, M.; Ogawa, T.; Vallance, P.; Wilcox, C.S. Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney. Kidney Int. 1997, 52, 1593-1601.
12. Arrigoni, F.I.; Vallance, P.; Haworth, S.G.; Leiper, J.M. Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. Circulation 2003, 107, 1195-1201.
13. Matsuoka, H.; Itoh, S.; Kimoto, M.; Kohno, K.; Tamai, O.; Wada, Y.; Yasukawa, H.; Iwami, G.; Okuda, S.; Imaizumi, T. Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension 1997, 29, 242-247.
14. Fujiwara, N.; Osanai, T.; Kamada, T.; Katoh, T.; Takahashi, K.; Okumura, K. Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension: Modulation of nitric oxide synthesis by salt intake. Circulation 2000, 101, 856-861.
15. Fang, Y.; Mu, J.J.; He, L.C.; Wang, S.C.; Liu, Z.Q. Salt loading on plasma asymmetrical dimethylarginine and the protective role of potassium supplement in normotensive salt-sensitive Asians. Hypertension 2006, 48, 724-729.
16. Du Cailar, G.; Ribstein, J.; Daures, J.P.; Mimran, A. Sodium and left ventricular mass in untreated hypertensive and normotensive subjects. Am. J. Physiol. Heart Circ. Physiol. 1992, 263, H177-H181.
17. Tuomilehto, J.; Jousilahti, P.; Rastenyte, D.; Moltchanov, V.; Tanskanen, A.; Pietinen, P.; Nissinen, A. Urinary sodium excretion and cardiovascular mortality in Finland: A prospective study. Lancet 2001, 357, 848-851.
18. Safar, M.; Thuilliez, C.; Richard, V.; Benetos, A. Pressure-independent contribution of sodium to large artery structure and function in hypertension. Cardiovasc. Res. 2000, 46, 269-276.
19. Reckelhoff, J.F.; Romero, J.C. Role of oxidative stress in angiotensin-induced hypertension. Am. J. Physiol. Regul. Integr. Compar. Physiol. 2003, 284, R893-R912.
20. Zhu, J.; Mori, T.; Huang, T.; Lombard, J.H. Effect of high-salt diet on NO release and superoxide production in rat aorta. Am. J. Physiol. Heart Circ. Physiol. 2004, 286, H575-H583.
21. Henry, C.; Burrell, L.M.; Black, M.J.; Wu, L.L.; Dilley, R.J.; Cooper, M.E.; Johnston, C.I. Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats. Circulation 1998, 98, 2621-2628.
22. Fujita, T. Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome. Hypertension 2010, 55, 813-818.
23. Förstermann, U.; Münzel, T. Endothelial nitric oxide synthase in vascular disease. Circulation 2006, 113, 1708-1714.
24. Li, H.; Förstermann, U. Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease. Curr. Opin. Pharmacol. 2013, in press.
25. Barton, M.; Vos, I.; Shaw, S.; Boer, P.; D'uscio, L.V.; Gröne, H.-J.; Rabelink, T.J.; Lattmann, T.; Moreau, P.; Lüscher, T.F. Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and glomerulosclerosis. J. Am. Soc. Nephrol. 2000, 11, 835-845.
26. Zhou, M.S.; Adam, A.G.; Jaimes, E.A.; Raij, L. In salt-sensitive hypertension, increased superoxide production is linked to functional upregulation of angiotensin II. Hypertension 2003, 42, 945-951.
27. Taylor, N.E.; Maier, K.G.; Roman, R.J.; Cowley, A.W., Jr. NO synthase uncoupling in the kidney of dahl s rats role of dihydrobiopterin. Hypertension 2006, 48, 1066-1071.
28. Swei, A.; Lacy, F.; DeLano, F.A.; Schmid-Schönbein, G.W. Oxidative stress in the Dahl hypertensive rat. Hypertension 1997, 30, 1628-1633.
29. Wilcox, C.S. Asymmetric dimethylarginine and reactive oxygen species unwelcome twin visitors to the cardiovascular and kidney disease tables. Hypertension 2012, 59, 375-381.
30. Tian, N.; Thrasher, K.D.; Gundy, P.D.; Hughson, M.D.; Manning, R.D. Antioxidant treatment prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension. Hypertension 2005, 45, 934-939.
31. Sydow, K.; Münzel, T. ADMA and oxidative stress. Atheroscl. Suppl. 2003, 4, 41-51.
32. Achan, V.; Broadhead, M.; Malaki, M.; Whitley, G.; Leiper, J.; MacAllister, R.; Vallance, P. Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arteriosc. Thromb. Vasc. Biol. 2003, 23, 1455-1459.
33. Pope, A.J.; Karrupiah, K.; Kearns, P.N.; Xia, Y.; Cardounel, A.J. Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production. J. Biol. Chem. 2009, 284, 35338-35347.
34. Liu, F.; Mu, J.; Liu, Z.; Shi, D.; Huang, Q.; Yuan, Z.; Lian, Q.; Zheng, S. Endothelial dysfunction in normotensive salt-sensitive subjects. J. Hum. Hypertens. 2011, 26, 247-252.
35. Ogawa, T.; Kimoto, M.; Sasaoka, K. Purification and properties of a new enzyme, NG, NG-dimethylarginine dimethylaminohydrolase, from rat kidney. J. Biol. Chem. 1989, 264, 10205-10209.