SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes

Biology of Reproduction

Volumn 88, Issue 1, 2013, Pages

  Lim, Ratana ^a,b   Barker, Gillian ^a,b   Lappas, Martha ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MERCY HOSPITAL FOR WOMEN   (Australia)

Author keywords

Cytokines; Human preterm labor; NFKB; Prostaglandins; SIRT6

Indexed keywords

CYCLOOXYGENASE 2; GELATINASE B; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; SIRTUIN 6; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AMNION CELL; ARTICLE; CESAREAN SECTION; CYTOKINE RELEASE; FEMALE; FETUS MEMBRANE; GENETIC TRANSFECTION; HUMAN; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

ADULT; CELLS, CULTURED; EXTRAEMBRYONIC MEMBRANES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; NF-KAPPA B; OBSTETRIC LABOR, PREMATURE; PREGNANCY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIRTUINS;

EID: 84877066538     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.112.105163     Document Type: Article

References (42)

1. Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH, Rubens C, Menon R, Van Look PF. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ 2010; 88(1):31-38.
2. Lawn JE, Kerber K, Enweronu-Laryea C, Cousens S. 3.6 million neonatal deaths-what is progressing and what is not? Semin Perinatol 2010; 34(6):371-386.
3. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371(9606):75-84.
4. Bastek JA, Gomez LM, Elovitz MA. The role of inflammation and infection in preterm birth. Clin Perinatol 2011; 38(3):385-406.
5. Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 2008; 371(9608):261-269.
6. Moster D, Lie RT, Markestad T. Long-term medical and social consequences of preterm birth. N Engl J Med 2008; 359(3):262-273.
7. Barros FC, Bhutta ZA, Batra M, Hansen TN, Victora CG, Rubens CE. Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions. BMC Pregnancy Childbirth 2010; 10(Suppl 1):S3.
8. Bowen JM, Chamley L, Keelan JA, Mitchell MD. Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition. Placenta 2002; 23(4):257-273.
9. Christiaens I, Zaragoza DB, Guilbert L, Robertson SA, Mitchell BF, Olson DM. Inflammatory processes in preterm and term parturition. J Reprod Immunol 2008; 79(1):50-57.
10. Olson DM. The role of prostaglandins in the initiation of parturition. Best Pract Res Clin Obstet Gynaecol 2003; 17(5):717-730.
11. Fata JE, Ho AT, Leco KJ, Moorehead RA, Khokha R. Cellular turnover and extracellular matrix remodeling in female reproductive tissues. functions of metalloproteinases and their inhibitors. Cell Mol Life Sci 2000; 57(1):77-95.
12. Lappas M, Rice GE. Phospholipase A2 isozymes in pregnancy and parturition. Prostaglandins Leukot Essent Fatty Acids 2004; 70(2):87-100.
13. Lappas M, Permezel M, Georgiou HM, Rice GE. Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro. Biol Reprod 2002; 67(2):668-673.
14. Lappas M, Permezel M, Georgiou HM, Rice GE. Regulation of phospholipase isozymes by nuclear factor-kappaB in human gestational tissues in vitro. J Clin Endocrinol Metab 2004; 89(5):2365-2372.
15. Lappas M, Permezel M, Rice GE. N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro. J Clin Endocrinol Metab 2003; 88(4):1723-1729.
16. Lappas M, Rice GE. The role and regulation of the nuclear factor kappa B signalling pathway in human labour. Placenta 2007; 28(5-6):543-556.
17. Lappas M, Rice GE. Transcriptional regulation of the processes of human labour and delivery. Placenta 2009; 30:S90-S95.
18. Lindstrom TM, Bennett PR. The role of nuclear factor kappa B in human labour. Reproduction 2005; 130(5):569-581.
19. Csiszar A, Wang M, Lakatta EG, Ungvari Z. Inflammation and endothelial dysfunction during aging: role of NF-kappa B. J Applied Physiol 2008;105(4):1333-1341.
20. Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. SIRT1 longevity factor suppresses NF-kappa B -driven immune responses: regulation of aging via NF-kappa B acetylation? Bioessays 2008; 30(10):939-942.
21. Shakibaei M, Buhrmann C, Mobasheri A. Resveratrol-mediated SIRT-. interactions with p300 modulate receptor activator of NF-kappa B ligand (RANKL) activation of NF-kappa B signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem 2011; 286(13):11492-11505.
22. Lappas M, Mitton A, Lim R, Barker G, Riley C, Permezel M. SIRT1 is a novel regulator of key pathways of human labor. Biol Reprod 2011; 84(1):167-178.
23. Van Gool F, Galli M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med 2009; 15(2):206-210.
24. Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-beta-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2011; 300(3):L391-L401.
25. Lappas M. Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells. Mediators Inflamm 2012; 2012:597514.
26. Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TLA, Barrett JC, Chang HY, Bohr VA, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008; 452(7186):492-496.
27. Kawahara TLA, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KCL, Boxer LD, Chang HY, Chua KF. SIRT. links histone H3 lysine 9 deacetylation to NF-[kappa]B-dependent gene expression and organismal life span. Cell 2009; 136(1):62-74.
28. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006; 124(2):315-329.
29. Lim R, Riley C, Barker G, Rice GE, Lappas M. Human labour is associated with decreased cytoplasmic FoxO4. Placenta 2012; 33(1):52-59.
30. Lappas M, Riley C, Lim R, Barker G, Rice GE, Menon R, Permezel M. MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: regulation of enzymes involved in the degradation of fetal membranes. Placenta 2011; 32(12):1016-1025.
31. Lappas M, Permezel M, Rice GE. 15-Deoxy-delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. Placenta 2006; 27(11-12):1060-1072.
32. Lanoix D, St-Pierre J, Lacasse AA, Viau M, Lafond J, Vaillancourt C. Stability of reference proteins in human placenta: general protein stains are the benchmark. Placenta 2012; 33(3):151-156.
33. Moore RM, Mansour JM, Redline RW, Mercer BM, Moore JJ. The physiology of fetal membrane rupture: insight gained from the determination of physical properties. Placenta 2006; 27(11-12):1037-1051.
34. Lappas M, Odumetse TL, Riley C, Reti NG, Holdsworth-Carson SJ, Rice GE, Permezel M. Pre-labour fetal membranes overlying the cervix display alterations in inflammation and NF-kappaB signalling pathways. Placenta 2008; 29(12):995-1002.
35. Reti NG, Lappas M, Riley C, Wlodek ME, Permezel M, Walker S, Rice GE. Why do membranes rupture at term? Evidence of increased cellular apoptosis in the supracervical fetal membranes. Am J Obstet Gynecol 2007; 196(5):484 e481-410.
36. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000; 342(20):1500-1507.
37. Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, Chaiworapongsa T, Mazor M. The preterm parturition syndrome. BJOG 2006; 113(Suppl 3):17-42.
38. Romero R, Durum S, Dinarello CA, Oyarzun E, Hobbins JC, Mitchell MD. Interleukin-1 stimulates prostaglandin biosynthesis by human amnion. Prostaglandins 1989; 37(1):13-22.
39. Arechavaleta-Velasco F, Ogando D, Parry S, Vadillo-Ortega F. Production of matrix metalloproteinase-9 in lipopolysaccharide-stimulated human amnion occurs through an autocrine and paracrine proinflammatory cytokine-dependent system. Biol Reprod 2002; 67(6):1952-1958.
40. Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008; 132(3):344-362.
41. Berkman ND, Thorp JM Jr, Lohr KN, Carey TS, Hartmann KE, Gavin NI, Hasselblad V, Idicula AE. Tocolytic treatment for the management of preterm labor: a review of the evidence. Am J Obstet Gynecol 2003;188(6):1648-1659.
42. Mackeen AD, Seibel-Seamon J, Grimes-Dennis J, Baxter JK, Berghella V. Tocolytics for preterm premature rupture of membranes. Cochrane Database Syst Rev 2011; 10:CD007062.