Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat

Zhongguo Zhongyao Zazhi

Volumn 38, Issue 3, 2013, Pages 381-385

  Huang, Zhen Gui ^a   Bai, Song ^a   Chen, Li ^a   Wang, Jiang Tao ^a   Ding, Bo Ping ^a  

^a WANNAN MEDICAL COLLEGE   (China)

Author keywords

Apelin; APJ; Ischemic and non ischemic kidneys; Puerarin combined with felodipine; Renovascular hypertensive rat

Indexed keywords

APELIN; CAPTOPRIL; FELODIPINE; PUERARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; KIDNEY ISCHEMIA; NONHUMAN; PROTEIN EXPRESSION; RAT; RENOVASCULAR HYPERTENSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHAM PROCEDURE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOTTING, WESTERN; CAPTOPRIL; DRUG SYNERGISM; FELODIPINE; GENE EXPRESSION; HYPERTENSION, RENOVASCULAR; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISCHEMIA; ISOFLAVONES; KIDNEY; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VASODILATOR AGENTS;

EID: 84877061455     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20130318     Document Type: Article

References (13)

1. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor [J]. Biochem Biophys Res Commun, 1998, 251(2): 471.
2. Chandra S M, Razavi H, Kim J, et al. Disruption of the Apelin-APJ system worsens hypoxia-induced pulmonary hypertension [J]. Arterioscler Thromb Vase Biol, 2011, 31(4): 814.
3. Sun X, Iida S, Yoshikawa A, Senbonmatsu R, et al. Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas Apelin-activated APJ acts conversely [J]. Hypertens Res, 2011, 34(6): 701.
4. 2011, 27(12): 2323.
5. Zhang N B, Huang Z G, Cui W D, et al. Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat[J]. J Ethnopharmacol, 2011, 138(3): 737.
6. Duke L M, Widdop R E, Kett M M, et al. AT2 receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension [J]. Br J Pharmacol, 2005, 144(4): 486.
7. 2010, 26(2): 26.
8. Ishida J, Hashimoto T, Hashimoto Y, et al. Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo [J]. J Biol Chem, 2004, 279 (25): 26274.
9. Kidoya H, Ueno M, Yamada Y, et al. Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis[J]. EMBO J, 2008, 27(3): 522.
10. Yu Q C, Hirst C E, Costa M, et al. Apelin promotes hematopoi-esis from human embryonic stem cells [J]. Blood, 2012, 119 (26): 6243.
11. Yokomori H, Oda M, Yoshimura K, et al. Enhanced expressions of apelin on proliferative hepatic arterial capillaries in human cirrhotic liver[J]. Hepatol Res, 2012, 42(5): 508.
12. Pisarenko O I, Shulzhenko V S, Pelogeykina Y A, et al. Attenuation of myocardial ischemia and reperfusion injury by novel analogues of apelin-12[J]. Int J Pharm Biomed Res, 2012, 3(1): 16.
13. Hekmat A S, Najafipour H, Nekooian A A, et al. Cardiovascular responses to apelin in two-kidney-one-clip hypertensive rats and its receptor expression in ischemic and non-ischemic kidneys [J]. Regul Pept, 2011, 172(1/3): 62.