메뉴 건너뛰기




Volumn 74, Issue 5, 2013, Pages 771-778

Effect of bevacizumab on angiogenesis and growth of canine osteosarcoma cells xenografted in athymic mice

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; VASCULOTROPIN;

EID: 84877060906     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.74.5.771     Document Type: Article
Times cited : (20)

References (56)
  • 2
    • 67349167237 scopus 로고    scopus 로고
    • Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma
    • Thomas R, Wang HJ, Tsai PC, et al. Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Res 2009;17:365-377.
    • (2009) Chromosome Res , vol.17 , pp. 365-377
    • Thomas, R.1    Wang, H.J.2    Tsai, P.C.3
  • 3
    • 0026841122 scopus 로고
    • Prognosis for dogs with appendicular osteosarcoma treated by amputation alone: 162 cases (1978-1988)
    • Spodnick GJ, Berg J, Rand WM, et al. Prognosis for dogs with appendicular osteosarcoma treated by amputation alone: 162 cases (1978-1988). J Am Vet Med Assoc 1992;200:995-999.
    • (1992) J Am Vet Med Assoc , vol.200 , pp. 995-999
    • Spodnick, G.J.1    Berg, J.2    Rand, W.M.3
  • 4
    • 3042524562 scopus 로고    scopus 로고
    • Effect of thalidomide on growth and metastasis of canine osteosarcoma cells after xenotransplantation in athymic mice
    • Farese JP, Fox LE, Detrisac C, et al. Effect of thalidomide on growth and metastasis of canine osteosarcoma cells after xenotransplantation in athymic mice. Am J Vet Res 2004;65:659-664.
    • (2004) Am J Vet Res , vol.65 , pp. 659-664
    • Farese, J.P.1    Fox, L.E.2    Detrisac, C.3
  • 5
    • 77449128013 scopus 로고    scopus 로고
    • Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression
    • Available at, Accessed Dec 1, 2010
    • Paoloni M, Davis S, Lana S, et al. Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. BMC Genomics [serial online]. 2009;10:625. Available at: www.biomedcentral.com/1471-2164/10/625. Accessed Dec 1, 2010.
    • (2009) BMC Genomics [serial Online] , vol.10 , pp. 625
    • Paoloni, M.1    Davis, S.2    Lana, S.3
  • 6
    • 38549112058 scopus 로고    scopus 로고
    • Translation of new cancer treatments from pet dogs to humans
    • Paoloni M, Khanna C. Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer 2008;8:147-156.
    • (2008) Nat Rev Cancer , vol.8 , pp. 147-156
    • Paoloni, M.1    Khanna, C.2
  • 7
    • 0029012086 scopus 로고
    • Results of surgery and doxorubicin chemotherapy in dogs with osteosarcoma
    • Berg J, Weinstein MJ, Springfield DS, et al. Results of surgery and doxorubicin chemotherapy in dogs with osteosarcoma. J Am Vet Med Assoc 1995;206:1555-1560.
    • (1995) J Am Vet Med Assoc , vol.206 , pp. 1555-1560
    • Berg, J.1    Weinstein, M.J.2    Springfield, D.S.3
  • 8
    • 0023841177 scopus 로고
    • Use of cisplatin for treatment of appendicular osteosarcoma in dogs
    • Shapiro W, Fossum TW, Kitchell BE, et al. Use of cisplatin for treatment of appendicular osteosarcoma in dogs. J Am Vet Med Assoc 1988;192:507-511.
    • (1988) J Am Vet Med Assoc , vol.192 , pp. 507-511
    • Shapiro, W.1    Fossum, T.W.2    Kitchell, B.E.3
  • 9
    • 0030094970 scopus 로고    scopus 로고
    • Amputation and carboplatin for treatment of dogs with osteosarcoma: 48 cases (1991 to 1993)
    • Bergman PJ, MacEwen EG, Kurzman ID, et al. Amputation and carboplatin for treatment of dogs with osteosarcoma: 48 cases (1991 to 1993). J Vet Intern Med 1996;10:76-81.
    • (1996) J Vet Intern Med , vol.10 , pp. 76-81
    • Bergman, P.J.1    Macewen, E.G.2    Kurzman, I.D.3
  • 10
    • 0026575299 scopus 로고
    • Evaluation of survival times after limb amputation, with and without subsequent administration of cisplatin, for treatment of appendicular osteosarcoma in dogs: 30 cases (1979-1990)
    • Thompson JP, Fugent MJ. Evaluation of survival times after limb amputation, with and without subsequent administration of cisplatin, for treatment of appendicular osteosarcoma in dogs: 30 cases (1979-1990). J Am Vet Med Assoc 1992;200:531-533.
    • (1992) J Am Vet Med Assoc , vol.200 , pp. 531-533
    • Thompson, J.P.1    Fugent, M.J.2
  • 11
    • 0026765346 scopus 로고
    • Treatment of dogs with osteosarcoma by administration of cisplatin after amputation or limb-sparing surgery: 22 cases (1987-1990)
    • Berg J, Weinstein MJ, Schelling SH, et al. Treatment of dogs with osteosarcoma by administration of cisplatin after amputation or limb-sparing surgery: 22 cases (1987-1990). J Am Vet Med Assoc 1992;200:2005-2008.
    • (1992) J Am Vet Med Assoc , vol.200 , pp. 2005-2008
    • Berg, J.1    Weinstein, M.J.2    Schelling, S.H.3
  • 13
    • 33847693960 scopus 로고    scopus 로고
    • Comparative biology of human and canine osteosarcoma
    • Mueller F, Fuchs B, Kaser-Hotz B. Comparative biology of human and canine osteosarcoma. Anticancer Res 2007;27:155-164.
    • (2007) Anticancer Res , vol.27 , pp. 155-164
    • Mueller, F.1    Fuchs, B.2    Kaser-Hotz, B.3
  • 14
    • 57749202046 scopus 로고    scopus 로고
    • Vascular targeted therapies in oncology
    • Siemann DW, Horsman MR. Vascular targeted therapies in oncology. Cell Tissue Res 2009;335:241-248.
    • (2009) Cell Tissue Res , vol.335 , pp. 241-248
    • Siemann, D.W.1    Horsman, M.R.2
  • 15
    • 0027053487 scopus 로고
    • Potent synergism between vascular endothelial cell growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
    • Pepper MS, Ferrara N, Orci L. Potent synergism between vascular endothelial cell growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun 1992;189:824-831.
    • (1992) Biochem Biophys Res Commun , vol.189 , pp. 824-831
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3
  • 16
    • 80053237717 scopus 로고    scopus 로고
    • Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma
    • Yang J, Yang D, Sun Y, et al. Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma. Cancer 2011;117:4925-4938.
    • (2011) Cancer , vol.117 , pp. 4925-4938
    • Yang, J.1    Yang, D.2    Sun, Y.3
  • 17
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomized controlled trial
    • Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomized controlled trial. Lancet 2006;368:1329-1338.
    • (2006) Lancet , vol.368 , pp. 1329-1338
    • Demetri, G.D.1    van Oosterom, A.T.2    Garrett, C.R.3
  • 18
    • 74549210540 scopus 로고    scopus 로고
    • Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK 1/2, MCL-1, ezrin pathways
    • Pignochino Y, Grignani G, Cavalloni G, et al. Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK 1/2, MCL-1, ezrin pathways. Mol Cancer 2009;8:118.
    • (2009) Mol Cancer , vol.8 , pp. 118
    • Pignochino, Y.1    Grignani, G.2    Cavalloni, G.3
  • 19
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre S, Demetri G, Sargent W, et al. Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 2007;6:734-745.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3
  • 20
    • 49549116204 scopus 로고    scopus 로고
    • VEGF165 is necessary to the metastatic potential of Fas- osteosarcoma cells but will not rescue the Fas+ cells
    • Jia SF, Guan H, Duan X, et al. VEGF165 is necessary to the metastatic potential of Fas- osteosarcoma cells but will not rescue the Fas+ cells. J Exp Ther Oncol 2008;7:89-97.
    • (2008) J Exp Ther Oncol , vol.7 , pp. 89-97
    • Jia, S.F.1    Guan, H.2    Duan, X.3
  • 21
    • 42049116924 scopus 로고    scopus 로고
    • VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro
    • Mei J, Gao Y, Zhang L, et al. VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. Exp Oncol 2008;30:29-34.
    • (2008) Exp Oncol , vol.30 , pp. 29-34
    • Mei, J.1    Gao, Y.2    Zhang, L.3
  • 22
    • 20644432867 scopus 로고    scopus 로고
    • Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer
    • Hurwitz HI, Fehrenbacher L, Hainsworth JD, et al. Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer. J Clin Oncol 2005;23:3502-3508.
    • (2005) J Clin Oncol , vol.23 , pp. 3502-3508
    • Hurwitz, H.I.1    Fehrenbacher, L.2    Hainsworth, J.D.3
  • 23
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 24
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller KD, Chap LI, Holmes FA, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005;23:792-799.
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 25
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22:2184-2191.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 26
    • 33644968548 scopus 로고    scopus 로고
    • Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer
    • Crane CH, Ellis LM, Abbruzzese JL, et al. Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer. J Clin Oncol 2006;24:1145-1151.
    • (2006) J Clin Oncol , vol.24 , pp. 1145-1151
    • Crane, C.H.1    Ellis, L.M.2    Abbruzzese, J.L.3
  • 27
    • 33646351795 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
    • Zhu AX, Blaszkowsky LS, Ryan DP, et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006;24:1898-1903.
    • (2006) J Clin Oncol , vol.24 , pp. 1898-1903
    • Zhu, A.X.1    Blaszkowsky, L.S.2    Ryan, D.P.3
  • 28
    • 68849115579 scopus 로고    scopus 로고
    • Therapeutic vulnerability of an in vivo model of soft part sarcoma (ASPS) to anti-angiogenic therapy
    • Vistica DT, Hollingshead M, Borgel SD, et al. Therapeutic vulnerability of an in vivo model of soft part sarcoma (ASPS) to anti-angiogenic therapy. J Pediatr Hematol Oncol 2009;31:561- 570.
    • (2009) J Pediatr Hematol Oncol , vol.31 , pp. 561
    • Vistica, D.T.1    Hollingshead, M.2    Borgel, S.D.3
  • 29
    • 27244450145 scopus 로고    scopus 로고
    • Phase II study of doxorubicin and bevacizumab for patients with metastatic softtissue sarcomas
    • D'Adamo DR, Anderson SE, Albritton K, et al. Phase II study of doxorubicin and bevacizumab for patients with metastatic softtissue sarcomas. J Clin Oncol 2005;23:7135-7142.
    • (2005) J Clin Oncol , vol.23 , pp. 7135-7142
    • D'Adamo, D.R.1    Anderson, S.E.2    Albritton, K.3
  • 30
    • 84870779349 scopus 로고    scopus 로고
    • US National Institutes of Health Clinical Trials, Available at: clinicaltrials.gov/ct2/show/ NCT00667342?term=osteosarcoma+bevacizumab&rank=1
    • US National Institutes of Health Clinical Trials. A study of bevacizumab in combination with chemotherapy for treatment of osteosarcoma. 2011. Available at: clinicaltrials.gov/ct2/show/ NCT00667342?term=osteosarcoma+bevacizumab&rank=1. Accessed Jan 17, 2011.
    • (2011) A Study of Bevacizumab In Combination With Chemotherapy For Treatment of Osteosarcoma
  • 31
    • 0033109480 scopus 로고    scopus 로고
    • Establishment and characterization of the growth and pulmonary metastasis of a highly lung metastasizing cell line from canine osteosarcoma in nude mice
    • Barroga EF, Kadosawa T, Okumura M, et al. Establishment and characterization of the growth and pulmonary metastasis of a highly lung metastasizing cell line from canine osteosarcoma in nude mice. J Vet Med Sci 1999;61:361-367.
    • (1999) J Vet Med Sci , vol.61 , pp. 361-367
    • Barroga, E.F.1    Kadosawa, T.2    Okumura, M.3
  • 32
    • 58549121179 scopus 로고    scopus 로고
    • Development of an intramuscular xenograft model of canine osteosarcoma in mice for evaluation of the effects of radiation therapy
    • Coomer AR, Farese JP, Milner R, et al. Development of an intramuscular xenograft model of canine osteosarcoma in mice for evaluation of the effects of radiation therapy. Am J Vet Res 2009;70:127-133.
    • (2009) Am J Vet Res , vol.70 , pp. 127-133
    • Coomer, A.R.1    Farese, J.P.2    Milner, R.3
  • 33
    • 12244252749 scopus 로고    scopus 로고
    • Gene therapy delivery of endostatin enhances the treatment efficacy of radiation
    • Shi W, Teschendorf C, Muzyczka N, et al. Gene therapy delivery of endostatin enhances the treatment efficacy of radiation. Radiother Oncol 2003;66:1-9.
    • (2003) Radiother Oncol , vol.66 , pp. 1-9
    • Shi, W.1    Teschendorf, C.2    Muzyczka, N.3
  • 34
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 35
    • 53549126631 scopus 로고    scopus 로고
    • Bevacizumab improves the overall and progression-free survival of patients with metastatic colorectal cancer treated with 5-fluorouracil-based regimens irrespective of baseline risk
    • Kabbinavar F, Irl C, Zurlo A, et al. Bevacizumab improves the overall and progression-free survival of patients with metastatic colorectal cancer treated with 5-fluorouracil-based regimens irrespective of baseline risk. Oncology 2008;75:215-223.
    • (2008) Oncology , vol.75 , pp. 215-223
    • Kabbinavar, F.1    Irl, C.2    Zurlo, A.3
  • 36
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M, et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 2005;23:3697-3705.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 37
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen C, O'Connor SH, et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997;57:4593-4599.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, C.2    O'Connor, S.H.3
  • 38
    • 34147145341 scopus 로고    scopus 로고
    • Concurrent cetuximab and bevacizumab therapy in a murine orthotopic model of anaplastic thyroid carcinoma
    • Prichard CN, Kim S, Yazici YD, et al. Concurrent cetuximab and bevacizumab therapy in a murine orthotopic model of anaplastic thyroid carcinoma. Laryngoscope 2007;117:674-679.
    • (2007) Laryngoscope , vol.117 , pp. 674-679
    • Prichard, C.N.1    Kim, S.2    Yazici, Y.D.3
  • 39
    • 79956011942 scopus 로고    scopus 로고
    • Induction of VEGF by tepoxalin does not lead to increased tumour growth in a canine osteosarcoma xenograft
    • Sottnik JL, Hansen RJ, Gustafson DL, et al. Induction of VEGF by tepoxalin does not lead to increased tumour growth in a canine osteosarcoma xenograft. Vet Comp Oncol 2011;9:118-130.
    • (2011) Vet Comp Oncol , vol.9 , pp. 118-130
    • Sottnik, J.L.1    Hansen, R.J.2    Gustafson, D.L.3
  • 40
    • 49049086508 scopus 로고    scopus 로고
    • Dual targeting of tumor vasculature: Combining antiangiogenic (Avastin) and vascular disrupting (CA4P or OXi4503) agent therapy
    • Siemann DW, Shi W. Dual targeting of tumor vasculature: combining antiangiogenic (Avastin) and vascular disrupting (CA4P or OXi4503) agent therapy. Anticancer Res 2008;28:2027-2031.
    • (2008) Anticancer Res , vol.28 , pp. 2027-2031
    • Siemann, D.W.1    Shi, W.2
  • 41
    • 0028946970 scopus 로고
    • Suppression of pulmonary metastasis by angiogenesis inhibitor TNP-470 in murine osteosarcoma
    • Mori S, Ueda T, Kuratsu S, et al. Suppression of pulmonary metastasis by angiogenesis inhibitor TNP-470 in murine osteosarcoma. Int J Cancer 1995;61:148-152.
    • (1995) Int J Cancer , vol.61 , pp. 148-152
    • Mori, S.1    Ueda, T.2    Kuratsu, S.3
  • 42
    • 12744281278 scopus 로고    scopus 로고
    • Endostatin cDNA/cationic liposome complexes as a promising therapy to prevent lung metastases in osteosarcoma: Study in a human-like rat orthotopic tumor
    • Dutour A, Monteil J, Paraf F, et al. Endostatin cDNA/cationic liposome complexes as a promising therapy to prevent lung metastases in osteosarcoma: study in a human-like rat orthotopic tumor. Mol Ther 2005;11:311-319.
    • (2005) Mol Ther , vol.11 , pp. 311-319
    • Dutour, A.1    Monteil, J.2    Paraf, F.3
  • 43
    • 85172062315 scopus 로고    scopus 로고
    • R&D Systems Inc, Available at, Accessed Feb 1, 2012
    • R&D Systems Inc. Quantikine ELISA human VEGF immunoassay. 2012. Available at: www.rndsystems.com/pdf/dve00.pdf. Accessed Feb 1, 2012.
    • (2012) Quantikine ELISA Human VEGF Immunoassay
  • 44
    • 0033371927 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors in tumor-bearing dogs
    • Scheidegger P, Weiglhofer W, Suarez S, et al. Vascular endothelial growth factor (VEGF) and its receptors in tumor-bearing dogs. Biol Chem 1999;380:1449-1454.
    • (1999) Biol Chem , vol.380 , pp. 1449-1454
    • Scheidegger, P.1    Weiglhofer, W.2    Suarez, S.3
  • 45
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4:423-436.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 46
    • 34547818190 scopus 로고    scopus 로고
    • Continuous low-dose oral chemotherapy for adjuvant treatment of splenic hemangiosarcoma in dogs
    • Lana S, U'ren L, Plaza S, et al. Continuous low-dose oral chemotherapy for adjuvant treatment of splenic hemangiosarcoma in dogs. J Vet Intern Med 2007;21:764-769.
    • (2007) J Vet Intern Med , vol.21 , pp. 764-769
    • Lana, S.1    U'Ren, L.2    Plaza, S.3
  • 47
    • 18844467502 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis
    • Kaya M, Wada T, Akatsuka T, et al. Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. Clin Cancer Res 2000;6:572-577.
    • (2000) Clin Cancer Res , vol.6 , pp. 572-577
    • Kaya, M.1    Wada, T.2    Akatsuka, T.3
  • 48
    • 36949011202 scopus 로고    scopus 로고
    • High VEGF with rapid growth and early metastasis in a mouse osteosarcoma model
    • Available at, Accessed Jun 29
    • Yang SY, Yu H, Krygier JE, et al. High VEGF with rapid growth and early metastasis in a mouse osteosarcoma model. Sarcoma [serial online]. 2007;2007:1-7.Available at: www. hindawi.com/journals/srcm/2007/095628/abs/. Accessed Jun 29, 2011.
    • (2007) Sarcoma [serial Online] , pp. 1-7
    • Yang, S.Y.1    Yu, H.2    Krygier, J.E.3
  • 49
    • 79960316237 scopus 로고    scopus 로고
    • Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma
    • Lin F, Zheng S, Shen Z. Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. Med Oncol 2011;28:649-653.
    • (2011) Med Oncol , vol.28 , pp. 649-653
    • Lin, F.1    Zheng, S.2    Shen, Z.3
  • 50
    • 61749104120 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor concentrations and postsurgical outcome in dogs with osteosarcoma
    • Thamm DH, O'Brien MG, Vail DM. Serum vascular endothelial growth factor concentrations and postsurgical outcome in dogs with osteosarcoma. Vet Comp Oncol 2008;6:126-132.
    • (2008) Vet Comp Oncol , vol.6 , pp. 126-132
    • Thamm, D.H.1    O'Brien, M.G.2    Vail, D.M.3
  • 51
    • 0034306873 scopus 로고    scopus 로고
    • Targeting tumor blood vessels: An adjuvant strategy for radiation therapy
    • Siemann DW, Warrington KH Jr, Horsman MR. Targeting tumor blood vessels: an adjuvant strategy for radiation therapy. Radiother Oncol 2000;57:5-12.
    • (2000) Radiother Oncol , vol.57 , pp. 5-12
    • Siemann, D.W.1    Warrington Jr., K.H.2    Horsman, M.R.3
  • 52
    • 0033559212 scopus 로고    scopus 로고
    • Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models
    • Lozonschi L, Sunamura M, Kobari M, et al. Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models. Cancer Res 1999;59:1252- 1258.
    • (1999) Cancer Res , vol.59 , pp. 1252
    • Lozonschi, L.1    Sunamura, M.2    Kobari, M.3
  • 53
    • 0027970092 scopus 로고
    • Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • O'Reilly MS, Holmgren L, Shing Y, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994;79:315-328.
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1    Holmgren, L.2    Shing, Y.3
  • 54
    • 0033572414 scopus 로고    scopus 로고
    • Mouse endostatin inhibits the formation of lung and liver metastases
    • Yoon SS, Eto H, Lin CM, et al. Mouse endostatin inhibits the formation of lung and liver metastases. Cancer Res 1999;59:6251- 6256.
    • (1999) Cancer Res , vol.59 , pp. 6251
    • Yoon, S.S.1    Eto, H.2    Lin, C.M.3
  • 55
    • 20344394640 scopus 로고    scopus 로고
    • The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large advanced tumors
    • Siemann DW, Rojiani AM. The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large advanced tumors. Int J Radiat Oncol Biol Phys 2005;62:846-853.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 846-853
    • Siemann, D.W.1    Rojiani, A.M.2
  • 56
    • 12444319243 scopus 로고    scopus 로고
    • Phase I doseescalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies
    • London CA, Hannah AL, Zadovoskaya R, et al. Phase I doseescalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies. Clin Cancer Res 2003;9:2755-2768.
    • (2003) Clin Cancer Res , vol.9 , pp. 2755-2768
    • London, C.A.1    Hannah, A.L.2    Zadovoskaya, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.