Design, ADMET and docking studies on some novel chalcone derivatives as soluble epoxide hydrolase enzyme inhibitors

Journal of the Chilean Chemical Society

Volumn 57, Issue 4, 2012, Pages 1442-1446

  Asokkumar, Kuppusamy ^a   Prathyusha, Lokeswari Tangella ^a   Umamaheshwari, Muthusamy ^a   Sivashanmugam, Thirumalaisamy ^a   Subhadradevi, Varadharajan ^a   Jagannath, Puliyath ^a   Madeswaran, Arumugam ^a   Salesheir, Francis ^a  

^a SRI RAMAKRISHNA INSTITUTE OF PARAMEDICAL SCIENCES   (India)

Author keywords

ADMET; Binding energy; Chalcones; Docking; Human soluble epoxide hydrolase

Indexed keywords

EID: 84877059854     PISSN: 07179324     EISSN: 07179707     Source Type: Journal    
DOI: 10.4067/S0717-97072012000400022     Document Type: Article

References (16)

1. S. Ekins, Y. Nikolsky, T. Nikolskaya, Trends Pharmacol. Sci. 26, 202 (2005).
2. W.J. Egan, G. Zlokarnik, P.D.J. Grootenhuis, Drug Dis.Today Tech.1, 381 (2004).
3. H. Yu, A. Adedoyin, Drug Disc. Therap. 8, 852 (2003).
4. A.A. Spector, J. Lipid Res. 50, S52 (2009).
5. H. Jiang, A.G. Zhu, M. Mamczur, C. Morisseau, B.D. Hammock, J.R. Falck, J.C. McGiff, J. Pharmacol. Exp. Therap. 326, 330 (2008).
6. U.R. Michealis, I. Fleming, Pharmacol. Theraps.111, 584 (2006).
7. A.A. Spector, X. Fang, G.D. Snyder, N.L. Weintraub, Progress Lip. Res. 43, 55 (2004).
8. K.L. Fife, Y. Liu, K.R. Schmelzer, H.J. Tsai, I.H. Kim, C. Morisseau, B.D. Hammock, D.L. Kroetz, Pharmacol. Exp. Therap. 327, 707 (2008).
9. I.H. Kim, F.R. Heirtzler, C. Morisseau, K. Nishi, H.J. Tsai, B.D. Hammock, J. Med. Chem. 48, 3621 (2005).
10. S. Norwood, J. Liao, B.D. Hammock, G.Y. Yang, Am. J. Transl. Res. 2, 447 (2010).
11. T. Kasagami, I.H. Kim, H.J. Tsai, K. Nishi, B.D. Hammock, C. Morisseau, Bio. Med. Chem. Let. 19, 1784 (2009).
12. N.R. McElroy, P.C. Jurs, J. Med. Chem. 46, 1066 (2003).
13. Y. Nakagawa, C.E. Wheelock, C. Morisseau, M.H. Goodrow, B.G. Hammock, B.D. Hammock, Bio. Med. Chem. 8, 2663 (2000).
14. C.A. Lipinski, F. Lombardo, B.W. Dominy, P.J. Feeney, Adv. Drug Del. Rev. 46, 3 (2001).
15. G.M. Morris, R. Huey, W. Lindstrom, M.F. Sanner, R.K. Belew, D.S. Goodsell, A.J. Olson, J. Comput. Chem. 19(14), 2785 (2009).
16. A. Madeswaran, M. Umamaheswari, K. Asokkumar, T. Sivashanmugam, V. Subhadradevi, P. Jagannath, In silico docking studies of lipoxygenase inhibitory activity of commercially available flavonoids. Orient Pharm Exp Med 12, 157 (2012).