Pancreatic islet cell autophagy during aging in rats

Clinical and Investigative Medicine

Volumn 36, Issue 2, 2013, Pages

  Wang, Shuang ^a   Sun, Qian qian ^a   Xiang, Bing ^a   Li, Xiu Jun ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LC3 PROTEIN, RAT; LIPID; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN;

AGING; ANIMAL; APOPTOSIS; ARTICLE; AUTOPHAGY; BLOOD; BODY WEIGHT; CYTOLOGY; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; METHODOLOGY; PANCREAS ISLET; PATHOPHYSIOLOGY; RAT; SECRETION (PROCESS); SPRAGUE DAWLEY RAT; TRANSMISSION ELECTRON MICROSCOPY;

AGING; ANIMALS; APOPTOSIS; AUTOPHAGY; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; INSULIN; ISLETS OF LANGERHANS; LIPIDS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84877034863     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Jung HS, Lee MS. Macroautophagy in homeostasis of pancreatic β-cell. Autophagy 2009; 5: 241-3.
2. Lerman-Garber I, Rosales-Calderón M. Changes in glucose tolerance in elderly. Revista de Investigación Clinica 2010; 62: 312-7.
3. Yousefi S, Perozzo R, Schmid I, et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nature Cell Biology 2006; 8: 1124-32.
4. Hur KY, Jung HS, Lee MS. Role of autophagy in β-cell function and mass. Diabetes, Obesity & Metabolism 2010; 12: 20-6.
5. Marchetti P, Masini M. Autophagy and the pancreatic B-cell in human type 2 diabetes. Autophagy 2009; 5:1055-6.
6. Masini M, Bugliani M, Lupi R, et al. Autophagy in human type 2 diabetes pancreatic beta-cells. Diabetologia 2009; 52: 1083-6.
7. Fujitani Y, Kawamori R, Watada H. The role of autophagy in pancreatic β-cell and diabetes. Autophagy 2009; 5: 280-282.
8. Rajawat YS, Hilioti Z, Bossis I. Aging: central role for autophagy and the lysosomal degradative system. Ageing Res Rev 2009; 8:199-21.
9. Jung HS, Lee MS. Role of autophagy in diabetes and mitochondria. Ann N Y Acad Sci 2010; 1201:79-83.
10. Andreollo NA, Santos EF, Araújo MR, et al. Rat's age versus human's age: what is the relationship? Arq Bras Cir Dig 2012; 25: 49-51.
11. Mizushima N. Methods for monitoring autophagy. The International Journal of Biochemistry & Cell Biology 2004; 36: 2491-502.
12. Vance JE, Buchanan KD, Challoner DR, Williams RH. Effect of glucose concentration on insulin and glucagon release from islets of Langerhans of rat, Diabetes 1968; 17: 187-93.
13. Ohsumi, Y. Molecular dissection of autophagy: two ubiquitinlike systems. Nat Rev Mol Cell Biol 2001; 2: 211-6.
14. Zois CE, Giatromanolaki A, Sivridis E, et al. "Autophagic flux" in normal mouse tissues: Focus on endogenous LC3A processing. Autophagy 2011; 7: 1371-8.
15. Fortunato F, Kroemer G. Impaired autophagosome-lysosome fusion in the pathogenesis of pancreatitis. Autophagy 2009; 5: 850-3.
16. Ebato C, Uchida T, Arakawa M, et al. Autophagy is important in islet homeostasis and compensatory increase of Beta cell mass in response to high-fat diet. Cell Metab 2008; 4: 325-332.
17. Klionsky DJ, Abeliovich H, Agostinis P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008; 4: 151-175.