Nitric oxide is a regulator of hematopoietic stem cell activity

Molecular Therapy

Volumn 10, Issue 2, 2004, Pages 241-248

  Michurina, Tatyana ^a   Krasnov, Peter ^a   Balazs, Alejandro ^b   Nakaya, Naoki ^a   Vasilieva, Tamara ^c   Kuzin, Boris ^a,c   Khrushchov, Nikolay ^c   Mulligan, Richard C ^b   Enikolopov, Grigori ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c KOL TSOV INSTITUTE OF DEVELOPMENTAL BIOLOGY   (Russian Federation)

Author keywords

Bone marrow; Differentiation; Hematopoiesis; Nitric oxide; Stem cells; Transplantation

Indexed keywords

CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL ACTIVITY; CELL COUNT; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; EXPOSURE; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LEUKOCYTE COUNT; MALE; MOUSE; MULTIPOTENT STEM CELL; NICK END LABELING; NONHUMAN; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WHOLE BODY RADIATION;

ANIMALS; BONE MARROW; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; ENZYME INHIBITORS; FEMALE; GAMMA RAYS; GENE EXPRESSION; HEMATOPOIETIC STEM CELLS; MALE; MICE; NEUTROPHILS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RNA, MESSENGER;

EID: 4344574192     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.05.030     Document Type: Article

References (42)

1. Williams W.J. Hematology 4th ed. 1990 McGraw-Hill New York
2. Morrison S.J. Uchida N. Weissman I.L. The biology of hematopoietic stem cells Annu. Rev. Cell Dev. Biol. 11 1995 35-71
3. + cells Exp. Hematol. 26 1998 53-62
4. Bradford G.B. Williams B. Rossi R. Bertoncello I. Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment Exp. Hematol. 25 1997 445-453
5. Mahmud N. et al. The relative quiescence of hematopoietic stem cells in nonhuman primates Blood 97 2001 3061-3068
6. Cheshier S.H. Morrison S.J. Liao X. Weissman I.L. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells Proc. Natl. Acad. Sci. USA 96 1999 3120-3125
7. Cheng T. Rodrigues N. Dombkowski D. Stier S. Scadden D.T. Stem cell repopulation efficiency but not pool size is governed by p27(kip1) Nat. Med. 6 2000 1235-1240
8. Cheng T. et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1 Science 287 2000 1804-1808
9. Antonchuk J. Sauvageau G. Humphries R.K. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo Cell 109 2002 39-45
10. Kyba M. Perlingeiro R.C. Daley G.Q. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors Cell 109 2002 29-37
11. Lessard J. Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells Nature 423 2003 255-260
12. Park I.K. et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells Nature 423 2003 302-305
13. Ignarro L.J. Nitric Oxide: Biology and Pathobiology 1st ed. 2000 Academic Press San Diego
14. Forstermann U. Boissel J.P. Kleinert H. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III) FASEB J. 12 1998 773-790
15. Wallerath T. Gath I. Aulitzky W.E. Pollock J.S. Kleinert H. Forstermann U. Identification of the NO synthase isoforms expressed in human neutrophil granulocytes, megakaryocytes and platelets Thromb. Haemostasis 77 1997 163-167
16. Amin A.R. et al. Expression of nitric oxide synthase in human peripheral blood mononuclear cells and neutrophils J. Inflammation 47 1995 190-205
17. Sase K. Michel T. Expression of constitutive endothelial nitric oxide synthase in human blood platelets Life Sci. 57 1995 2049-2055
18. Chen L.Y. Mehta J.L. Variable effects of l-arginine analogs on l-arginine-nitric oxide pathway in human neutrophils and platelets may relate to different nitric oxide synthase isoforms J. Pharmacol. Exp. Ther. 276 1996 253-257
19. Greenberg S.S. Ouyang J. Zhao X. Giles T.D. Human and rat neutrophils constitutively express neural nitric oxide synthase mRNA Nitric Oxide 2 1998 203-212
20. Maciejewski J.P. et al. Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha J. Clin. Invest. 96 1995 1085-1092
21. + human bone marrow cells Blood 87 1996 977-982
22. Punjabi C.J. Laskin D.L. Heck D.E. Laskin J.D. Production of nitric oxide by murine bone marrow cells: Inverse correlation with cellular proliferation J. Immunol. 149 1992 2179-2184
23. Enikolopov G. Banerji J. Kuzin B. Nitric oxide and Drosophila development Cell Death Differ. 6 1999 956-963
24. Punjabi C.J. Laskin J.D. Hwang S.M. MacEachern L. Laskin D.L. Enhanced production of nitric oxide by bone marrow cells and increased sensitivity to macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF after benzene treatment of mice Blood 83 1994 3255-3263
25. Kuzin B. Roberts I. Peunova N. Enikolopov G. Nitric oxide regulates cell proliferation during Drosophila development Cell 87 1996 639-649
26. Kuzin B. Regulski M. Stasiv Y. Scheinker V. Tully T. Enikolopov G. Nitric oxide interacts with the retinoblastoma pathway to control eye development in Drosophila Curr. Biol. 10 2000 459-462
27. Wingrove J.A. O'Farrell P.H. Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila Cell 98 1999 105-114
28. Champlin D.T. Truman J.W. Ecdysteroid coordinates optic lobe neurogenesis via a nitric oxide signaling pathway Development 127 2000 3543-3551
29. Peunova N. Scheinker V. Cline H. Enikolopov G. Nitric oxide is an essential negative regulator of cell proliferation in Xenopus brain J. Neurosci. 21 2001 8809-8818
30. Packer M.A. et al. Nitric oxide negatively regulates mammalian adult neurogenesis Proc. Natl. Acad. Sci. USA 100 2003 9566-9571
31. Cheng A. Wang S. Cai J. Rao M.S. Mattson M.P. Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain Dev. Biol. 258 2003 319-333
32. Moreno-Lopez B. Romero-Grimaldi C. Noval J.A. Murillo-Carretero M. Matarredona E.R. Estrada C. Nitric oxide is a physiological inhibitor of neurogenesis in the adult mouse subventricular zone and olfactory bulb J. Neurosci. 24 2004 85-95
33. Aicher A. et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells Nat. Med. 9 2003 1370-1376
34. Poluha W. et al. A novel, nerve growth factor-activated pathway involving nitric oxide, p53, and p21WAF1 regulates neuronal differentiation of PC12 cells J. Biol. Chem. 272 1997 24002-24007
35. Ishida A. Sasaguri T. Kosaka C. Nojima H. Ogata J. Induction of the cyclin-dependent kinase inhibitor p21(Sdi1/Cip1/Waf1) by nitric oxide-generating vasodilator in vascular smooth muscle cells J. Biol. Chem. 272 1997 10050-10057
36. Nakaya N. Lowe S.W. Taya Y. Chenchik A. Enikolopov G. Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest Oncogene 19 2000 6369-6375
37. Gu M. Lynch J. Brecher P. Nitric oxide increases p21(Waf1/Cip1) expression by a cGMP-dependent pathway that includes activation of extracellular signal-regulated kinase and p70(S6k) J. Biol. Chem. 275 2000 11389-11396
38. Hemish J. Nakaya N. Mittal V. Enikolopov G. Nitric oxide activates diverse signaling pathways to regulate gene expression J. Biol. Chem. 278 2003 42321-42329
39. Heissig B. et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand Cell 109 2002 625-637
40. Stamler J.S. Lamas S. Fang F.C. Nitrosylation: The prototypic redox-based signaling mechanism Cell 106 2001 675-683
41. Kim S.O. et al. OxyR: A molecular code for redox-related signaling Cell 109 2002 383-396
42. Wink D.A. et al. Mechanisms of the antioxidant effects of nitric oxide Antioxid. Redox Signaling 3 2001 203-213