Early maternal separation: Neurobehavioral consequences in mother rats

Behavioural Brain Research

Volumn 248, Issue , 2013, Pages 25-31

  Aguggia, Julieta Paola ^a   Suárez, Marta Magdalena ^a   Rivarola, María Angélica ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Amygdala; Anxiety; Depression; Learning; Maternal behavior; Memory

Indexed keywords

PROTEIN C FOS;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; CENTRAL NUCLEUS (AMYGDALA); CONTROLLED STUDY; DELIVERY; DEPRESSION; FEMALE; LATENT PERIOD; LONG TERM MEMORY; MATERNAL CARE; MATERNAL DEPRIVATION; MOTHER; NESTLING; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUERPERIUM; RAT; SHORT TERM MEMORY; STRESS;

ANIMALS; BEHAVIOR, ANIMAL; DEPRESSION; FEMALE; MATERNAL BEHAVIOR; MATERNAL DEPRIVATION; MEMORY, LONG-TERM; MOTHERS; POSTPARTUM PERIOD; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR;

EID: 84877027644     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2013.03.040     Document Type: Article

References (34)

1. Brunton P.J., Russell J.A., Douglas A.J. Adaptive responses of the maternal hypothalamic-pituitary-adrenal axis during pregnancy and lactation neuroendocrinology. Journal of Neuroendocrinology 2008, 7:764-776.
2. Brummelte S., Galea L.M. Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam. Hormones and Behavior 2010, 58:769-779.
3. Pryce C.R., Feldon J. Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms. Neuroscience & Biobehavioral Reviews 2003, 27:57-71.
4. Faturi C.B., Tiba P.A., Kawakami S.E., Catallani B., Kerstens M., Suchecki D. Disruptions of the mother-infant relationship and stress-related behaviours: altered corticosterone secretion does not explain everything. Neuroscience and Biobehavioral Reviews 2010, 34:821-834.
5. Lehmann J., Feldon J. Long-term biobehavioral effects of maternal separation in the rat: consistent or confusing?. Reviews in the Neurosciences 2000, 11:383-408.
6. Okabe S., Nagasawa M., Mogi K. The importance of mother-infant communication for social bond formation in mammals. Animal Science Journal 2012, 83:446-452.
7. Mogi K., Nagasawa M. Developmental consequences and biological significance of mother-infant bonding. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2011, 35:1232-1241.
8. Kalinichev M., Easterling K.W., Holtzman S.G. Long-lasting changes in morphine-induced locomotor sensitization and tolerance in Long-Evans mother rats as a result of periodic postpartum separation from the litter: a novel model of increased vulnerability to drug abuse?. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 2003, 28:317-328.
9. Kalinichev M., Easterling K.W., Holtzman S.G. Periodic postpartum separation from the offspring results in long-lasting changes in anxiety-related behaviors and sensitivity to morphine in Long-Evans mother rats. Psychopharmacology 2000, 152(17):431-439.
10. Boccia M.L., Razzoli M., Vadlamudi S.P., Trumbull W., Caleffie C., Pedersen C.A. Repeated long separations from pups produce depression-like behavior in rat mothers. Psychoneuroendocrinology 2007, 32:65-71.
11. Sung Y.-H., Shin M.-S., Cho S., Baik H.-H., Jin B.-K., Chang H.-K., et al. Depression-like state in maternal rats induced by repeated separation of pups is accompanied by a decrease of cell proliferation and an increase of apoptosis in the hippocampus. Neuroscience Letters 2010, 470:86-90.
12. Maniam J., Morris M.J. Long-term postpartum anxiety and depression-like behavior in mother rats subjected to maternal separation are ameliorated by palatable high fat diet. Behavioural Brain Research 2010, 208:72-79.
13. Von Poser Toigo E., Diehl L.A., Ferreira A.G.K., Mackedanz V., Mackendanz V., Krolow R., et al. Maternal depression model: long-lasting effects on the mother following separation from pups. Neurochemical Research 2012, 37:126-133.
14. Eklund M.B., Johansson L.M., Uvnäs-Moberg K., Arborelius L. Differential effects of repeated long and brief maternal separation on behaviour and neuroendocrine parameters in Wistar dams. Behavioural Brain Research 2009, 203:69-75.
15. Lonstein J.S. Regulation of anxiety during the postpartum period. Frontiers in Neuroendocrinology 2007, 28:115-141.
16. Hillerer K.M., Reber S.O., Neumann I.D., Slattery Da. Exposure to chronic pregnancy stress reverses peripartum-associated adaptations: implications for postpartum anxiety and mood disorders. Endocrinology 2011, 152:3930-3940.
17. Tarantino L.M., Sullivan P.F., Meltzer-Brody S. Using animal models to disentangle the role of genetic, epigenetic, and environmental influences on behavioral outcomes associated with maternal anxiety and depression. Frontiers in Psychiatry 2011, 2:1-10.
18. Pearlstein T., Howard M., Salisbury A., Zlotnick C. Postpartum depression. American Journal of Obstetrics and Gynecology 2009, 200:357-364.
19. LeDoux J. The emotional brain, fear, and the amygdala. Cellular and Molecular Neurobiology 2003, 23:727-738.
20. Khoshbouei H., Cecchi M., Dove S., Javors M., Morilak D.A. Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala. Pharmacology Biochemistry and Behavior 2002, 71:407-417.
21. Huber D., Veinante P., Stoop R. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science (New York, NY) 2005, 308:245-248.
22. Brummelte S., Galea L.M. Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2010, 34:766-776.
23. Kurata A., Morinobu S., Fuchikami M., Yamamoto S., Yamawaki S. Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring. Hormones and Behavior 2009, 56:112-120.
24. Burkhammer M.D., Anderson G.C., Chiu S.-H. Grief, anxiety, stillbirth, and perinatal problems: healing with kangaroo care. Journal of Obstetric Gynecologic and Neonatal Nursing 2004, 33:774-782.
25. Lonstein J.S. Reduced anxiety in postpartum rats requires recent physical interactions with pups, but is independent of suckling and peripheral sources of hormones. Hormones and Behavior 2005, 47:241-255.
26. Neumann I.D. Brain mechanisms underlying emotional alterations in the peripartum period in rats. Depression and Anxiety 2003, 17:111-121.
27. Woodside B., Amir S. Lactation reduces Fos induction in the paraventricular and supraoptic nuclei of the hypothalamus after urethane administration in rats. Brain Research 1997, 752:319-323.
28. Huang T.-Y., Lin C.-H. Role of amygdala MAPK activation on immobility behavior of forced swim rats. Behavioural Brain Research 2006, 173:104-111.
29. Smith C.D., Lonstein J.S. Contact with infants modulates anxiety-generated c-Fos activity in the brains of postpartum rats. Behavioural Brain Research 2008, 190:193-200.
30. Leuner B., Shors T.J. Learning during motherhood: a resistance to stress. Hormones and Behavior 2006, 50:38-51.
31. Vivinetto A.L., Suárez M.M., Rivarola M.A. Neurobiological effects of neonatal maternal separation and post-weaning environmental enrichment. Behavioural Brain Research 2013, 240:110-118.
32. Slattery D.A., Uschold N., Magoni M., Bär J., Popoli M., Neumann I.D., et al. Behavioural consequences of two chronic psychosocial stress paradigms: anxiety without depression. Psychoneuroendocrinology 2012, 37:702-714.
33. Cryan J.F., Slattery D.A. Animal models of mood disorders: recent developments. Current Opinion in Psychiatry 2007, 20:201-207.
34. Krishnan V., Han M.H., Graham D.L., Berton O., Renthal W., Russo S.J., et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 2007, 131:391-404.