Periodic postpartum separation from the offspring results in long-lasting changes in anxiety-related behaviors and sensitivity to morphine in Long-Evans mother rats

Psychopharmacology

Volumn 152, Issue 4, 2000, Pages 431-439

  Kalinichev, M ^a   Easterling, K W ^a   Holtzman, S G ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antinociception; Fear and anxiety; Hot plate; Maternal separation; Opioid; Plus maze; Tail flick; Ultrasonic vocalization

Indexed keywords

MORPHINE;

ADOLESCENT; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; FEAR; FEMALE; HOT PLATE TEST; MATERNAL BEHAVIOR; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; PUERPERIUM; RAT; SEPARATION ANXIETY; TAIL FLICK TEST; ULTRASOUND; VOCALIZATION;

ANALGESICS, OPIOID; ANIMALS; FEAR; FEMALE; MALE; MAZE LEARNING; MORPHINE; MOTOR ACTIVITY; PAIN MEASUREMENT; PUERPERAL DISORDERS; RATS; RATS, LONG-EVANS; STARTLE REACTION; VOCALIZATION, ANIMAL;

EID: 0033662522     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000556     Document Type: Article

References (83)

1. Assessment of relative intrinsic activity of mu-opioid analgesics in vivo using β-funaltrexamine
2. Effects of early experience on adrenocortical reactivity
3. Naloxone blocks the antianxiety but not the motor effects of benzodiazepines and pentobarbital: Experimental studies and literature review
4. Endogenous opioids: Biology and function
5. Reciprocity and resource exchange. A symbiotic model of parent-offspring relations
6. Early experience, ultrasonic vocalizations, and maternal responsiveness in rats
7. Comparison of different behavioral test situations used in psychopharmacology for measurement of anxiety
8. The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines
9. Early maternal separation alters postpartum pup-licking and grooming, lactation-associated changes in aggression and anxiety, and central oxytocin binding in female offspring
10. Effects of opioid peptides on peripheral stimulation and 'stress' induced analgesia in animals
11. Biochemical basis of parental behavior in the rat
12. Immunoreactive beta-endorphin concentrations in brain and plasma during pregnancy in rats: Possible modulation by progesterone and estradiol
13. The effects of early rearing environment on the development of GABA(A) and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat
14. Ethopharmacological analysis of rat behavior on the elevated plus-maze
15. Chronic exposure to a novel odor increases pups' vocalizations, maternal care, and alters dopaminergic functioning in developing mice
16. A method of determining loss of pain sensation
17. The tail flick test
18. Naloxone blocks the effect of diazepam and meprobamate on conflict behavior in rats
19. Naloxone attenuates the anxiolytic action of diazepam in man
20. Neonatal maternal separation produces a profile of altered corticosterone levels and sensitivity to morphine
21. The biological basis of anxiety
22. Recent developments in anxiety, stress, and depression
23. Anxiolytic effects in the plus-maze of 5-HT(1A) receptor ligands in dorsal raphe and ventral hippocampus
24. Naltrexone potentiates the anxiolytic effects of chlordiazepoxide in rats exposed to novel environments
25. Distress vocalizations in rat pups. A simple screening method for anxiolytic drugs
26. Development and maintenance of morphine tolerance and dependence in the rat by scheduled access to morphine drinking solutions
27. Ontogeny of opiate mechanisms in relation to the sequential development of neurons known to be components of the guinea pig's enteric nervous system
28. Continuous recording of maternal behavior in Rattus norvegicus
29. Preoptic area opioids and opiate receptors increase during pregnancy and decrease during lactation
30. Morphine effects on maternal aggression, pup care and analgesia in mice
31. Measurement of exploratory behavior in rodents
32. Persistent changes in corticotropin-releasing factor system due to early life stress: Relationship to the pathophysiology of major depression and post-traumatic stress disorder
33. Anxiolytic 2,3-benzodiazepines, their specific binding to the basal ganglia
34. Startle-inducing acoustic stimuli evoke ultrasonic vocalization in the rat
35. Acoustic startle induced ultrasonic vocalization in the rat: A novel animal model of anxiety?
36. Overexpression of proenkephalin in the amygdala potentiates the anxiolytic effects of benzodiazepines
37. Effects of intracerebroventricular infusions of naltrexone and phentolamine on central and peripheral oxytocin release and on maternal behavior induced by vaginocervical stimulation in the ewe
38. Morphine and corticotrophin-releasing factor potentiate maternal acceptance in multiparous ewes after vaginocervical stimulation
39. Effects of naloxone on the anticonflict properties of alcohol and chlordiazepoxide
40. Long-term changes in nest condition and pup grouping following handling of rat litters
41. Changes in licking behavior of rat mother following handling of young
42. Effects of mother-infant separation on maternal attachment behavior
43. Infantile experience and resistance to physiological stress
44. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
45. Influence of neonatal rearing conditions on stress-induced adrenocorticotropin responses and norepinephrine release in the hypothalamic paraventricular nucleus
46. Long-term effects of parity on opioid and nonopioid behavioral and endocrine responses
47. Opioid receptor sub-type involvement in maternal behavior in lactating rats
48. Opiate antagonism reduces placentophagia and pup cleaning by parturient rats
49. The effects of neonatal handling on the development of the adrenocortical response to stress: Implications for neuropathology and cognitive deficits in later life
50. Early environmental regulation of fore-brain glucocorticoid receptor gene expression: Implications for adrenocortical responses to stress
51. Opioid-like analgesia in defeated mice
52. Aggression, anxiety and vocalizations in animals: GABA(A) and 5-HT anxiolytics
53. Brain substrates of infant-mother attachment: Contributions of opioids, oxytocin, and norepinephrine
54. Brain opioids and motherinfant social motivation
55. Increased analgesic potency of mu agonists after continuous naloxone infusion in rats
56. Corticotropin-releasing hormone inhibits maternal behavior and induces pup-killing
57. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
58. Opioid peptides of the pituitary and hypothalamus: Changes in pregnant and lactating rats
59. Neonatal handling in rats induces long-term effects on dynorphin peptides
60. Early postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress induced release in adult rats
61. Effects of handling on maternal behavior in the mouse (Mus musculus): An observational study
62. Cortisol and behavioral responses to separation in mother and infant guinea pigs
63. Neuropeptides: Cellular morphology, major pathways, and functional considerations
64. Anxiety, defence and the elevated plus-maze
65. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze
66. Ultrasound and aggressive behavior in rats and other small mammals
67. Neuronal circuits involved in the anxiolytic effects of the 5-HT(1A) receptor agonist 8-OH-DPAT, ipsapirone and buspirone
68. Pituitary-adrenal responsiveness of rat mothers to noxious stimuli and stimuli produced by pups
69. Maternal pituitary-adrenal responsiveness as a function of differential treatment of rat pups
70. Maternal responsiveness following differential pup treatment and mother-pup interactions
71. Ontogenetic changes in pup-elicited maternal pituitary-adrenal activity: Pup age and stage of lactation effects
72. Diazepam and endorphin independently inhibit ultrasonic distress calls in rats
73. Involvement of the opioid system in the anxiolytic effects of diazepam in mice
74. Long ultrasonic calls in male rats following mating, defeat and aversive stimulation: Frequency modulation and bout structure
75. Temporal patterning of ultrasonic distress calls in the adult rat: Effects of morphine and benzodiazepines
76. GABA- and peptide-immunoreactivities co-localize in the rat central extended amygdala
77. Ultrasonic vocalizations in rat pups: Modulation at the gamma-aminobutyric acid(A) receptor complex and the neurosteroid recognition site
78. Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats
79. The infant rat separation paradigm: A novel test for novel anxiolytics
80. Rat strain differences in the potentiation of morphine-induced analgesia by stress
81. Interactive effects of parity and pup stress on the maternal behavior of Rattus norvegicus
82. Inhibitory effects of naltrexone on the induction of parental behavior in juvenile rats
83. Sustained corticosterone release in lactating rats following olfactory stimulation from the pups