A microfabricated platform to form three-dimensional toroidal multicellular aggregate

Biomedical Microdevices

Volumn 14, Issue 6, 2012, Pages 1085-1093

  Masuda, Taisuke ^a   Takei, Natsuki ^a   Nakano, Takuma ^b   Anada, Takahisa ^c   Suzuki, Osamu ^c   Arai, Fumihito ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b FUJIFILM CORPORATION   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Chondrocyte; Microfabrication; Multicellular aggregate; Spheroid; Three dimensional

Indexed keywords

AGGREGATES; BIOACTIVITY; CARDIOVASCULAR SYSTEM; CELL ENGINEERING; HISTOLOGY; HYBRID SYSTEMS; MICROFABRICATION; OXYGEN SUPPLY; STEM CELLS; THREE DIMENSIONAL COMPUTER GRAPHICS; TISSUE ENGINEERING;

CELLULAR AGGREGATES; CHONDROCYTES; GRAY SCALE PHOTOLITHOGRAPHY; LONG-TERM CULTURE; MULTICELLULAR AGGREGATES; SPHEROID; STEM CELL RESEARCH; THREEDIMENSIONAL (3-D);

TISSUE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CARTILAGE CELL; CELL DENSITY; CELL DIFFERENTIATION; CELL ENGINEERING; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CELLULAR PARAMETERS; COMPLEX FORMATION; CONTROLLED STUDY; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SCANNING ELECTRON MICROSCOPY; TOROIDAL MULTICELLULAR AGGREGATE FORMATION; ANIMAL; BIOLOGICAL MODEL; CELL AGGREGATION; CELL LINE; CELL SURVIVAL; CHEMISTRY; CULTURE TECHNIQUE; EQUIPMENT DESIGN; METHODOLOGY; MICROTECHNOLOGY; NANOTECHNOLOGY; TISSUE ENGINEERING;

DIMETICONE; NYLON; POLY(DIMETHYLSILOXANE) POLYAMIDE COPOLYMER; POLY(DIMETHYLSILOXANE)-POLYAMIDE COPOLYMER;

ANIMALS; CELL AGGREGATION; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; DIMETHYLPOLYSILOXANES; EQUIPMENT DESIGN; MICE; MICROTECHNOLOGY; MODELS, BIOLOGICAL; NANOTECHNOLOGY; NYLONS; TISSUE ENGINEERING;

EID: 84877019855     PISSN: 13872176     EISSN: 15728781     Source Type: Journal    
DOI: 10.1007/s10544-012-9713-0     Document Type: Article

References (40)

1. D.R. Albrecht, G.H. Underhill, T.B. Wassermann, R.L. Sah, S.N. Bhatia, Probing the role of multicellular organization in three-dimensional microenvironments. Nat. Methods 3, 369-375 (2006)
2. T. Anada, T. Masuda, Y. Honda, J. Fukuda, F. Arai, T. Fukuda et al., Three-dimensional cell culture device utilizing thin membrane deformation by decompression. Sensors Actuators B Chem. 147, 376-379 (2010)
3. U. Anderer, J. Libera, In vitro engineering of human autogenous cartilage. J. Bone Miner. Res. 17, 1420-1429 (2002)
4. J. Barrila, A.L. Radtke, A. Crabbé, S.F. Sarker, M.M. Herbst-Kralovetz, C.M. Ott et al., Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions. Nat. Rev. Micro. 8, 791-801 (2010)
5. T.J. Bartosh, J.H. Ylostalo, A. Mohammadipoor, N. Bazhanov, K. Coble, K. Claypool, et al. Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc. Natl. Acad. Sci. U S A. (2010)
6. D.C. Duffy, J.C. McDonald, O.J.A. Schueller, G.M. Whitesides, Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). Anal. Chem. 70, 4974-4984 (1998)
7. J. Fukuda, A. Khademhosseini, Y. Yeo, X. Yang, J. Yeh, G. Eng et al., Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures. Biomaterials 27, 5259-5267 (2006)
8. L.G. Griffith, M.A. Swartz, Capturing complex 3D tissue physiology in vitro. Nat. Rev. Mol. Cell Biol. 7, 211-224 (2006)
9. A. Hoshikawa, Y. Nakayama, T. Matsuda, H. Oda, K. Nakamura, K. Mabuchi, Encapsulation of chondrocytes in photopolymerizable styrenated gelatin for cartilage tissue engineering. Tissue Eng. 12, 2333-2341 (2006)
10. K. Itoga, J. Kobayashi, Y. Tsuda, M. Yamato, T. Okano, Second-generation maskless photolithography device for surface micropatterning and microfluidic channel fabrication. Anal. Chem. 80, 1323-1327 (2008)
11. W. Kafienah, M. Jakob, O. Demarteau, A. Frazer, M.D. Barker, I. Martin et al., Three-dimensional tissue engineering of hyaline cartilage: comparison of adult nasal and articular chondrocytes. Tissue Eng. 8, 817-826 (2002)
12. J.M. Kelm, N.E. Timmins, C.J. Brown, M. Fussenegger, L.K. Nielsen, Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol. Bioeng. 83, 173-180 (2003)
13. J.M. Kelm, V. Lorber, J.G. Snedeker, D. Schmidt, A. Broggini-Tenzer, M. Weisstanner et al., A novel concept for scaffold-free vessel tissue engineering: self-assembly of microtissue building blocks. J. Biotechnol. 148, 46-55 (2010)
14. A. Khademhosseini, R. Langer, J. Borenstein, J.P. Vacanti, Microscale technologies for tissue engineering and biology. Proc. Natl. Acad. Sci. U. S. A. 103, 2480-2487 (2006)
15. D. Kloss, M. Fischer, A. Rothermel, J.C. Simon, A.A. Robitzki, Drug testing on 3D in vitro tissues trapped on a microcavity chip. Lab. Chip. 8, 879-884 (2008)
16. W.M. Kulyk, J.L. Franklin, L.M. Hoffman, Sox9 expression during chondrogenesis in micromass cultures of embryonic limb mesenchyme. Exp. Cell Res. 255, 327-332 (2000)
17. L.A. Kunz-Schughart, M. Kreutz, R. Knuechel, Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology. Int. J. Exp. Pathol. 79, 1-23 (1998)
18. C.M. Livoti, J.R. Morgan, Self-assembly and tissue fusion of toroid-shaped minimal building units. Tissue Eng. Part A. 16, 2051-2061 (2010)
19. K. Mamchaoui, G. Saumon, A method for measuring the oxygen consumption of intact cell monolayers. Am. J. Physiol. Lung Cell Mol. Physiol. 278, L858-L863 (2000)
20. A.P. McGuigan, M.V. Sefton, Vascularized organoid engineered by modular assembly enables blood perfusion. Proc. Natl. Acad. Sci. U. S. A. 103, 11461-11466 (2006)
21. E. Metzen, M. Wolff, J. Fandrey, W. Jelkmann, Pericellular PO2 and O2 consumption in monolayer cell cultures. Respir. Physiol. 100, 101-106 (1995)
22. V. Mironov, R.P. Visconti, V. Kasyanov, G. Forgacs, C.J. Drake, R.R. Markwald, Organ printing: tissue spheroids as building blocks. Biomaterials 30, 2164-2174 (2009)
23. M. Miyazawa, T. Torii, Y. Toshimitsu, K. Okada, I. Koyama, Hepatocyte dynamics in a three-dimensional rotating bioreactor. J. Gastroenterol. Hepatol. 22, 1959-1964 (2007)
24. A.P. Napolitano, D.M. Dean, A.J. Man, J. Youssef, D.N. Ho, A.P. Rago et al., Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels. Biotechniques 43(494), 6-500 (2007)
25. J.W. Nichol, S.T. Koshy, H. Bae, C.M. Hwang, S. Yamanlar, A. Khademhosseini, Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials 31, 5536-5544 (2010)
26. D.C. O' Shea, W.S. Rockward, Gray-scale masks for diffractive-optics fabrication: II. Spatially filtered halftone screens. Appl. Opt. 34, 7518-7526 (1995)
27. J.T. Oliveira, T.C. Santos, L. Martins, M.A. Silva, A.P. Marques, A.G. Castro et al., Performance of new gellan gum hydrogels combined with human articular chondrocytes for cartilage regeneration when subcutaneously implanted in nude mice. J. Tissue Eng. Regen. Med. 3, 493-500 (2009)
28. H. Ota, R. Yamamoto, K. Deguchi, Y. Tanaka, Y. Kazoe, Y. Sato et al., Three-dimensional spheroid-forming lab-on-a-chip using micro-rotational flow. Sensors Actuators B Chem. 147, 359-365 (2010)
29. J. Rouwkema, J. de Boer, C.A. Van Blitterswijk, Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng. 12, 2685-2693 (2006)
30. T. Sasagawa, T. Shimizu, S. Sekiya, Y. Haraguchi, M. Yamato, Y. Sawa et al., Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology. Biomaterials 31, 1646-1654 (2010)
31. T. Shin'oka, Y. Imai, Y. Ikada, Transplantation of a tissue-engineered pulmonary artery. N. Engl. J. Med. 344, 532-533 (2001)
32. A. Skardal, S.F. Sarker, A. Crabbé, C.A. Nickerson, G.D. Prestwich, The generation of 3-D tissue models based on hyaluronan hydrogel-coated microcarriers within a rotating wall vessel bioreactor. Biomaterials 31, 8426-8435 (2010)
33. T.J. Suleski, D.C. O' Shea, Gray-scale masks for diffractive-optics fabrication: I. Commercial slide imagers. Appl. Opt. 34, 7507-7517 (1995)
34. J.Z. Tong, P. De Lagausie, V. Furlan, T. Cresteil, O. Bernard, F. Alvarez, Long-term culture of adult rat hepatocyte spheroids. Exp. Cell Res. 200, 326-332 (1992)
35. K. Totsu, K. Fujishiro, S. Tanaka, M. Esashi, Fabrication of three-dimensional microstructure using maskless gray-scale lithography. Sensors Actuators A Phys. 130-131, 387-392 (2006)
36. Y.C. Tung, A.Y. Hsiao, S.G. Allen, Y.S. Torisawa, M. Ho, S. Takayama, High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst 136, 473-478 (2011)
37. B.R. Unsworth, P.I. Lelkes, Growing tissues in microgravity. Nat. Med. 4, 901-907 (1998)
38. S. Wakitani, T. Kimura, A. Hirooka, T. Ochi, M. Yoneda, N. Yasui et al., Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel. J. Bone Joint Surg. Br. 71, 74-80 (1989)
39. M. Wartenberg, F. Donmez, F.C. Ling, H. Acker, J. Hescheler, H. Sauer, Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells. FASEB J. 15, 995-1005 (2001)
40. F. Yanagawa, H. Kaji, Y.H. Jang, H. Bae, D. Yanan, J. Fukuda, et al. Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs. J. Biomed. Mater. Res. A. (2011)