Progesterone vaginal ring versus vaginal gel for luteal support with in vitro fertilization: A randomized comparative study

Fertility and Sterility

Volumn 99, Issue 6, 2013, Pages 1543-1549

  Stadtmauer, Laurel ^a   Silverberg, Kaylen M ^b   Ginsburg, Elizabeth S ^c   Weiss, Herman ^d   Howard, Brandon ^e  

^a The Jones Institute for Reproductive Medicine   (United States)

^b Texas Fertility Center   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d Teva Women's Health   (Israel)

^e Teva Women's Health   (United States)

Author keywords

assisted reproductive technology; in vitro fertilization; luteal phase support; pregnancy; Progesterone; progesterone supplementation; vaginal ring

Indexed keywords

PROGESTERONE;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; ARTICLE; BACKACHE; BREAST TENDERNESS; CLINICAL EFFECTIVENESS; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DRUG DOSAGE FORM COMPARISON; DYSPEPSIA; ECTOPIC PREGNANCY; FATIGUE; FEMALE; FERTILIZATION IN VITRO; GEL; GESTATIONAL AGE; HEADACHE; HUMAN; INTERMETHOD COMPARISON; LIVE BIRTH; LUTEAL PHASE; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NAUSEA AND VOMITING; OOCYTE RETRIEVAL; PATIENT SAFETY; PELVIS PAIN SYNDROME; PHASE 3 CLINICAL TRIAL; PREGNANCY RATE; PRIORITY JOURNAL; PROGESTERONE VAGINAL GEL; PROGESTERONE VAGINAL RING; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SPONTANEOUS ABORTION; TREATMENT DURATION; URINARY TRACT INFECTION; VAGINA DISCHARGE; VAGINA RING;

ADOLESCENT; ADULT; CONTRACEPTIVE DEVICES, FEMALE; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; LIVE BIRTH; LUTEAL CELLS; PREGNANCY; PROGESTERONE; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; VAGINAL CREAMS, FOAMS, AND JELLIES; YOUNG ADULT;

EID: 84876992847     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2012.12.052     Document Type: Article

References (34)

1. A.S. Penzias Luteal phase support Fertil Steril 77 2002 318 323
2. M. van der Linden, K. Buckingham, C. Farquhar, J.A. Kremer, and M. Metwally Luteal phase support for assisted reproduction cycles Cochrane Database Syst Rev 10 2011 CD009154
3. M. Ludwig, and K. Diedrich Evaluation of an optimal luteal phase support protocol in IVF Acta Obstet Gynecol Scand 80 2001 452 466
4. S. Soliman, S. Daya, J. Collins, and E.G. Hughes The role of luteal phase support in infertility treatment: a meta-Analysis of randomized trials Fertil Steril 61 1994 1068 1076
5. S.J. Chantilis, K.M. Zeitoun, S.I. Patel, D.A. Johns, V.A. Madziar, and D.D. McIntire Use of Crinone vaginal progesterone gel for luteal support in in vitro fertilization cycles Fertil Steril 72 1999 823 829
6. S. Daya Luteal support: progestogens for pregnancy protection Maturitas 65 Suppl 1 2009 S29 S34
7. F.L. Licciardi, A. Kwiatkowski, N.L. Noyes, A.S. Berkeley, L.L. Krey, and J.A. Grifo Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study Fertil Steril 71 1999 614 618
8. J.L. Pouly, S. Bassil, R. Frydman, B. Hedon, B. Nicollet, and Y. Prada Luteal support after in-vitro fertilization: Crinone 8%, a sustained release vaginal progesterone gel, versus Utrogestan, an oral micronized progesterone Hum Reprod 11 1996 2085 2089
9. C. Bourgain, P. Devroey, L. Van Waesberghe, J. Smitz, and A.C. Van Steirteghem Effects of natural progesterone on the morphology of the endometrium in patients with primary ovarian failure Hum Reprod 5 1990 537 543
10. R.J. Paulson Hormonal induction of endometrial receptivity Fertil Steril 96 2011 530 535
11. C. Bulletti, D. de Ziegler, C. Flamigni, E. Giacomucci, V. Polli, and G. Bolelli Targeted drug delivery in gynaecology: the first uterine pass effect Hum Reprod 12 1997 1073 1079
12. R.A. Miles, R.J. Paulson, R.A. Lobo, M.F. Press, L. Dahmoush, and M.V. Sauer Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study Fertil Steril 62 1994 485 490
13. E. Cicinelli, D. de Ziegler, C. Bulletti, M.G. Matteo, L.M. Schonauer, and P. Galantino Direct transport of progesterone from vagina to uterus Obstet Gynecol 95 2000 403 406
14. N.J. Alexander, E. Baker, M. Kaptein, U. Karck, L. Miller, and E. Zampaglione Why consider vaginal drug administration? Fertil Steril 82 2004 1 12
15. Crinone® 4% and Crinone® 8% (progesterone gel) [prescribing information] 2010 Watson Pharmaceuticals Inc. Morristown, NJ
16. Endometrin® [prescribing information] 2007 Ferring Pharmaceuticals, Inc. Parsippany, NJ
17. K.J. Doody, V.L. Schnell, R.A. Foulk, C.E. Miller, B.A. Kolb, and E.J. Blake Endometrin for luteal phase support in a randomized, controlled, open-label, prospective in-vitro fertilization trial using a combination of Menopur and Bravelle for controlled ovarian hyperstimulation Fertil Steril 91 2009 1012 1017
18. J. Kleinstein Efficacy and tolerability of vaginal progesterone capsules (Utrogest 200) compared with progesterone gel (Crinone 8%) for luteal phase support during assisted reproduction Fertil Steril 83 2005 1641 1649
19. E.H. Ng, C.C. Chan, O.S. Tang, and P.C. Ho A randomized comparison of side effects and patient convenience between Cyclogest suppositories and Endometrin tablets used for luteal phase support in IVF treatment Eur J Obstet Gynecol Reprod Biol 131 2007 182 188
20. F. Zegers-Hochschild, J.P. Balmaceda, C. Fabres, V. Alam, A. Mackenna, and E. Fernandez Prospective randomized trial to evaluate the efficacy of a vaginal ring releasing progesterone for IVF and oocyte donation Hum Reprod 15 2000 2093 2097
21. L. Stadtmauer, D.D. Harrison, J. Boyd, S. Bocca, and S. Oehninger Pilot study evaluating a progesterone vaginal ring for luteal-phase replacement in donor oocyte recipients Fertil Steril 92 2009 1600 1605
22. Practice Committee of the American Society for Reproductive Medicine The clinical relevance of luteal phase deficiency: a committee opinion Fertil Steril 98 2012 1112 1117
23. B. Luke, M.B. Brown, J.E. Stern, S.A. Missmer, V.Y. Fujimoto, and R. Leach Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates Hum Reprod 26 2011 245 252
24. D.K. Shah, S.A. Missmer, K.F. Berry, C. Racowsky, and E.S. Ginsburg Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization Obstet Gynecol 118 2011 63 70
25. Practice Committee of the Society for Assisted Reproductive Technology Practice Committee of the American Society for Reproductive Medicine Guidelines on number of embryos transferred Fertil Steril 86 2006 S51 S52
26. P.W. Zarutskie, and J.A. Phillips A meta-Analysis of the route of administration of luteal phase support in assisted reproductive technology: vaginal versus intramuscular progesterone Fertil Steril 92 2009 163 169
27. B.J. Van Voorhis Outcomes from assisted reproductive technology Obstet Gynecol 107 2006 183 200
28. M.A. Damario, V.T. Goudas, D.R. Session, D.G. Hammitt, and D.A. Dumesic Crinone 8% vaginal progesterone gel results in lower embryonic implantation efficiency after in vitro fertilization-embryo transfer Fertil Steril 72 1999 830 836
29. A.M. Propst, J.A. Hill, E.S. Ginsburg, S. Hurwitz, J. Politch, and E.H. Yanushpolsky A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles Fertil Steril 76 2001 1144 1149
30. A. Abate, M. Perino, F.G. Abate, A. Brigandi, L. Costabile, and F. Manti Intramuscular versus vaginal administration of progesterone for luteal phase support after in vitro fertilization and embryo transfer. A comparative randomized study Clin Exp Obstet Gynecol 26 1999 203 206
31. E. Yanushpolsky, S. Hurwitz, L. Greenberg, C. Racowsky, and M. Hornstein Crinone vaginal gel is equally effective and better tolerated than intramuscular progesterone for luteal phase support in in vitro fertilization-embryo transfer cycles: a prospective randomized study Fertil Steril 94 2010 2596 2599
32. K.M. Silverberg, T.C. Vaughn, L.J. Hansard, N.Z. Burger, and T. Minter Vaginal (Crinone 8%) gel vs. intramuscular progesterone in oil for luteal phase support in in vitro fertilization: a large prospective trial Fertil Steril 97 2012 344 348
33. K. Doody, M. Bush, and M. Collins Progesterone supplementation for luteal support: efficacy and patient experiences with vaginal inserts (Endometrin®) versus intramuscular injection [abstract P-25] Fertil Steril 97 3 Suppl 2012 S18
34. Society for Assisted Reproductive Technology. 2010 Clinic Summary Report. https://sartcorsonline.com. Accessed June 28, 2012.