Lactulose Breath Test to Assess Oro-cecal Transit Delay and Estimate Esophageal Dysmotility in Scleroderma Patients

Seminars in Arthritis and Rheumatism

Volumn 42, Issue 5, 2013, Pages 522-529

  Gemignani, Lorenzo ^a   Savarino, Vincenzo ^a   Ghio, Massimo ^a   Parodi, Andrea ^a   Zentilin, Patrizia ^a   de Bortoli, Nicola ^b   Negrini, Simone ^a   Furnari, Manuele ^a   Dulbecco, Pietro ^a   Giambruno, Elisa ^a   Savarino, Edoardo ^a,c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

IEM; Lactulose breath test; Scleroderma; Systemic sclerosis

Indexed keywords

GLUCOSE; LACTULOSE; OCTANOIC ACID;

ADULT; AGED; ARTICLE; BACTERIAL OVERGROWTH; BREATH ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ESOPHAGUS DISEASE; ESOPHAGUS DYSMOTILITY; ESOPHAGUS MANOMETRY; ESOPHAGUS MOTILITY; FEMALE; HUMAN; INTESTINE TRANSIT TIME; MAJOR CLINICAL STUDY; MALE; NON INVASIVE MEASUREMENT; OROCECAL TRANSIT TIME; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; STOMACH EMPTYING; SYSTEMIC SCLEROSIS;

ADULT; AGED; AGED, 80 AND OVER; BREATH TESTS; ESOPHAGEAL MOTILITY DISORDERS; ESOPHAGUS; FEMALE; HUMANS; LACTULOSE; MALE; MANOMETRY; MIDDLE AGED; SCLERODERMA, SYSTEMIC; TIME FACTORS; YOUNG ADULT;

EID: 84876973377     PISSN: 00490172     EISSN: 1532866X     Source Type: Journal    
DOI: 10.1016/j.semarthrit.2012.09.004     Document Type: Article

References (34)

1. Derk C.T., Jimenez S.A. Systemic sclerosis: current views of its pathogenesis. Autoimmune Rev 2003, 2:181-191.
2. Tyndall A.J., Bannert B., Vonk M., Airò P., Cozzi F., Carreira P.E., et al. Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis 2010, 69(10):1809-1815.
3. Jaovisidha K., Csuka M.E., Almagro U.A., Soergel K.H. Severe gastrointestinal involvement in systemic sclerosis: report of five cases and review of the literature. Semin Arthritis Rheum 2005, 34(4):689-702.
4. Omair M.A., Lee P. Effect of gastrointestinal manifestations on quality of life in 87 consecutive patients with systemic sclerosis. J Rheumatol 2012, 39(5):992-996.
5. Khanna D., Hays R.D., Maranian P., Seibold J.R., Impens A., Mayes M.D., et al. Reliability and validity of the University of California, Los Angeles scleroderma clinical trial consortium gastrointestinal tract instrument. Arthritis Rheum 2009, 61(9):1257-1263.
6. Forbes A., Marie I. Gastrointestinal complications: the most frequent internal complications of systemic sclerosis. Rheumatology 2009, 48(Suppl. 3):6-9.
7. Thoua N.M., Bunce C., Brough G., Forbes A., Emmanuel A.V., Denton C.P. Assessment of gastrointestinal symptoms in patients with systemic sclerosis in a UK tertiary referral centre. Rheumatology (Oxford) 2010, 49(9):1770-1775.
8. Johnson S.R., Feldman B.M., Hawker G.A. Classification criteria for systemic sclerosis subsets. J Rheumatol 2007, 34:1855-1863.
9. Savarino E., Bazzica M., Zentilin P., Pohl D., Parodi A., Cittadini G., et al. Gastroesophageal reflux and pulmonary fibrosis in scleroderma: a study using pH-impedance monitoring. Am J Respir Crit Care Med 2009, 179:408-413.
10. Jorge J.M., Wexner S.D., Ehrenpreis E.D. The lactulose hydrogen breath test as a measure of orocaecal transit time. Eur J Surg 1994, 160:409-416.
11. Parodi A., Sessarego M., Greco A., Bazzica M., Filaci G., Setti M., et al. Small intestinal bacterial overgrowth in patients suffering from scleroderma: clinical effectiveness of its eradication. Am J Gastroenterol 2008, 103:1257-1262.
12. Marie I., Ducrotté P., Denis P., Menard J.F., Levesque H. Small intestinal bacterial overgrowth in systemic sclerosis. Rheumatology 2009, 48:1314-1319.
13. Husebye E. Gastrointestinal motility disorders and bacterial overgrowth. J Intern Med 1995, 237:419-427.
14. Furnari M., Savarino E., Bruzzone L., Moscatelli A., Gemignani L., Giannini E.G., et al. Reassessment of the role of methane production between irritable bowel syndrome and functional constipation. J Gastrointest Liver Dis 2012, 21(2):157-163.
15. Parodi A., Dulbecco P., Savarino E., Giannini E.G., Bodini G., Corbo M., et al. Positive glucose breath testing is more prevalent in patients with IBS-like symptoms compared with controls of similar age and gender distribution. J Clin Gastroenterol 2009, 43(10):962-966.
16. ®): toward standardization for testing gastric emptying of solids. Dig Liver Dis 2010, 42:549-553.
17. Marie I., Gourcerol G., Leroi A.M., Ménard J.F., Levesque H., Ducrotté P. Delayed gastric emptying determined using the (13) C-octanoic acid breath test in patients with systemic sclerosis. Arthritis Rheum 2012, 64(7):2346-2355. 10.1002/art.34374.
18. Gasbarrini A., Corazza G.R., Gasbarrini G., Montalto M., Di Stefano M., Basilisco G., et al. Methodology and indications of H2-breath testing in gastrointestinal diseases: the Rome Consensus Conference. Aliment Pharmacol Ther 2009, 29(Suppl. 1):1-49.
19. Rana S., Bhansali A., Bhadada S., Sharma S., Kaur J., Singh K. Orocecal transit time and small intestinal bacterial overgrowth in type 2 diabetes patients from North India. Diabetes Technol Ther 2011, 13(11):1115-1120.
20. Furnari M., Parodi A., Gemignani L., Giannini E.G., Marenco S., Savarino E., et al. Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth. Aliment Pharmacol Ther 2010, 32:1000-1006.
21. Savarino E., Gemignani L., Pohl D., Zentilin P., Dulbecco P., Assandri L., et al. Oesophageal motility and bolus transit abnormalities increase in parallel with the severity of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2011, 34(4):476-486.
22. Savarino E., Tutuian R. Combined multichannel intraluminal impedance and manometry testing. Dig Liver Dis 2008, 40(3):167-173.
23. Spechler S.J., Castell D.O. Classification of oesophageal motility abnormalities. Gut 2001, 49:145-151.
24. Ghoos Y., Maes B., Geypens B., Mys G., Hiele M.I., Rutgeerts P.J., et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 1993, 104:1640-1647.
25. Di Ciaula A., Covelli M., Berardino M., Wang D.Q., Lapadula G., Palasciano G., et al. Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma. BMC Gastroenterol 2008, 8:7.
26. Caserta L., De Magistris L. Assessment of intestinal permeability and orocecal transit time in patients with systemic sclerosis: analysis of relationships with epidemiologic and clinical parameters. Rheumatol Int 2003, 23:226-230.
27. Riordan S.M., McIver C.J., Walker B.M., Duncombe V.M., Bolin T.D., Thomas M.C. The lactulose breath hydrogen test and small intestinal bacterial overgrowth. Am J Gastroenterol 1996, 91:1795-1803.
28. Yu D., Cheeseman F., Vanner S. Combined oro-cecal scintigraphy and lactulose hydrogen breath testing demonstrate that breath testing detects oro-cecal transit, not small intestinal bacterial overgrowth in patients with IBS. Gut 2011, 60:334-340.
29. Fynne L., Worsøe J., Gregersen T., Schlageter V., Laurberg S., Krogh K. Gastrointestinal transit in patients with systemic sclerosis. Scand J Gastroenterol 2011, 46:1187-1193.
30. Soares R.V., Forsythe A., Hogarth K., Sweiss N.J., Noth I., Patti M.G. Interstitial lung disease and gastroesophageal reflux disease: key role of esophageal function tests in the diagnosis and treatment. Arq Gastroenterol 2011, 48:91-97.
31. Roman S., Hot A., Fabien N., Cordier J.F., Miossec P., Ninet J., et al. Esophageal dysmotility associated with systemic sclerosis: a high-resolution manometry study. Dis Esophagus 2010, 17. 10.1111/j.1442-2050.2010.01150.x.
32. Marie I., Dominique S., Levesque H., Ducrotté P., Denis P., Hellot M.F., et al. Esophageal involvement and pulmonary manifestations in systemic sclerosis. Arthritis Rheum 2001, 45:346-354.
33. Lee J.S., Ryu J.H., Elicker B.M., Lydell C.P., Jones K.D., Wolters P.J., et al. Gastroesophageal reflux therapy is associated with longer survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2011 Jun 23.
34. Doria A., Bonavina L., Anselmino M., Ruffatti A., Favaretto M., Gambari P., et al. Oesophageal involvement in mixed connective tissue disease. J Rheumatol 1991, 18:685-690.