Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence

Journal of Biological Chemistry

Volumn 288, Issue 17, 2013, Pages 12366-12375

  Riaz, Anjum ^a   Ilan, Neta ^b   Vlodavsky, Israel ^b,c   Li, Jin Ping ^a   Johansson, Staffan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c Department of the Israel Cancer Research Fund ^*  (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AKT ACTIVATION; AKT PHOSPHORYLATION; CHEMICAL INHIBITORS; MOUSE EMBRYONIC FIBROBLASTS; PHOSPHATIDYLINOSITOL; SIGNALING RECEPTOR; SUSPENSION CULTURES; WILD-TYPE CELLS;

CELL CULTURE; CELL PROLIFERATION; ENZYMES; GLYCOPROTEINS; PHOSPHORYLATION;

ACTIVATION ANALYSIS;

FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 2; GROWTH FACTOR; HEPARANASE; INTEGRIN; INTEGRIN LINKED KINASE; MAMMALIAN TARGET OF RAPAMYCIN; P21 ACTIVATED KINASE 1; P21 ACTIVATED KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P110ALPHA; RAS PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5; VITRONECTIN RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; CHO CELLS; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; CRICETINAE; CRICETULUS; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; ENZYME INHIBITORS; FIBROBLASTS; GLUCURONIDASE; HUMANS; INTEGRIN ALPHAVBETA3; MICE; P21-ACTIVATED KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, VITRONECTIN; SIGNAL TRANSDUCTION;

EID: 84876942159     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.435172     Document Type: Article

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