Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne

Journal of Cutaneous Medicine and Surgery

Volumn 17, Issue 2, 2013, Pages 114-122

  Jung, Gordon W ^a,b,c,d   Tse, Jennifer E ^a,b,c,d   Guiha, Isabella ^a,b,c,d   Rao, Jaggi ^a,b,c,d  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Shape MD   (Canada)

^c Acne Clinics of Canada   (Canada)

^d Dermatology and Cosmetic Laser Associates of San Diago   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MINOCYCLINE; PROBIOTIC AGENT;

ACNE VULGARIS; ADULT; CLINICAL ASSESSMENT; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SAFETY; DRUG TOLERABILITY; EVENING DOSAGE; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; REVIEW; VAGINA CANDIDIASIS;

ACNE VULGARIS; ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; BIFIDOBACTERIUM; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS DELBRUECKII; MINOCYCLINE; PROBIOTICS; QUALITY OF LIFE; YOUNG ADULT;

EID: 84876905518     PISSN: 12034754     EISSN: None     Source Type: Journal    
DOI: 10.2310/7750.2012.12026     Document Type: Review

References (22)

1. Friedlander SF, Eichenfield LF, Fowler JF Jr, et al. Acne epidemiology and pathophysiology. Semin Cutan Med Surg 2010;29(2 Suppl 1):2-4, doi:10.1016/j.sder.2010.04.002.
2. Halvorsen JA, Stern RS, Dalgard F, et al. Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study. J Invest Dermatol 2011;131:363-70, doi:10.1038/jid. 2010.264.
3. Simonart T, Dramaix M, De Maertelaer V. Efficacy of tetracyclines in the treatment of acne vulgaris: a review. Br J Dermatol 2008;158: 208-16.
4. Ashourian N, Cohen PR. Systemic antibacterial agents. In: Wolverton SE, editor. Comprehensive dermatologic drug therapy. 2nd ed. Philadelphia: Elsevier; 2007. p. 39-74.
5. Kurokawa I, Danby FW, Ju Q, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 2009;18:821-32, doi:10.1111/j.1600-0625.2009.00890.x.
6. Kircik LH. Doxycycline and minocycline for the management of acne: a review of efficacy and safety with emphasis on clinical implications. J Drugs Dermatol 2010;9:1407-11.
7. Sloan B, Scheinfeld N. The use and safety of doxycycline hyclate and other second generation tetracyclines. Expert Opin Drug Saf 2008;7:571-7, doi:10.1517/14740338.7.5.571.
8. FAO/WHO. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Report of a Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria. Có rdoba, Argentina: October 1-4, 2001.
9. Ruemmele FM, Bier D, Marteau P, et al. Clinical evidence for immunomodulatory effects of probiotic bacteria. J Pediatr Gastroenterol Nutr 2009;48:126-41, doi:10.1097/MPG.0b013e318 17d80ca.
10. Sazawal S, Hiremath G, Dhingra U, et al. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect Dis 2006;6: 374-82, doi:10.1016/S1473-3099(06)70495-9.
11. Song HJ, Kim JY, Jung SA, et al. Effect of probiotic Lactobacillus (LacidofilH cap) for the prevention of antibiotic-associated diarrhea: a prospective, randomized, double-blind,multicenter study. J Korean Med Sci 2010;25:1784-91, doi:10.3346/jkms.2010.25.12.1784.
12. Hilton E, Isenberg HD, Alperstein P, et al. Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis for candidal vaginitis. Ann Intern Med 1992;116:353-7.
13. Shalev E, Battino S, Weiner E, et al. Ingestion of yogurt containing Lactobacillus acidophilus compared with pasteurized yogurt as prophylaxis for recurrent candidal vaginitis and bacterial vaginosis. Arch Fam Med 1996;5:593-6, doi:10.1001/archfami. 5.10.593.
14. Pirotta M, Gunn J, Chondros P, et al. Effect of Lactobacillus in preventing post-antibiotic vulvovaginal candidiasis: a randomised controlled trial. BMJ 2004;329:548-52, doi:10.1136/bmj.38210.
15. .DE. 15. Williams AB, Yu C, Tashima K, et al. Evaluation of two self-care treatments for prevention of vaginal candidiasis in women with HIV. J Assoc Nurses AIDS Care 2001;12:51-7, doi:10.1016/S1055- 3290(06)60216-1.
16. Dessinioti C, Katsambas AD. The role of Propionibacterium acnes in acne pathogenesis: facts and controversies. Clin Dermatol 2010; 28:2-7, doi:10.1016/j.clindermatol.2009.03.012.
17. Grange PA, Raingeaud J, Calvez V, et al. Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kappaB and MAPK pathways. J Dermatol Sci 2009;56:106-12, doi:10.1016/j. jdermsci.2009.08.001.
18. Mouser PE, Baker BS, Seaton ED, et al. Propionibacterium acnesreactive T helper-1 cells in the skin of patients with acne vulgaris. J Invest Dermatol 2003;121:1226-8, doi:10.1046/j.1523-1747.2003.
19. Basal E, Jain A, Kaushal GP. Antibody response to crude cell lysate of Propionibacterium acnes and induction of pro-inflammatory cytokines in patients with acne and normal healthy subjects. J Microbiol 2004;42:117-25.
20. Kwon HK, Lee CG, So JS, et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci U S A 2010; 107:2159-64, doi:10.1073/pnas.0904055107.
21. Resta-Lenert S, Barrett KE. Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells. Gastroenterology 2006;130:731-46, doi:10.1053/j.gastro.2005.12.015.
22. Tien MT, Girardin SE, Regnault B, et al. Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol 2006;176:1228-37.