The use and safety of doxycycline hyclate and other second-generation tetracyclines

Expert Opinion on Drug Safety

Volumn 7, Issue 5, 2008, Pages 571-577

  Sloan, Barry ^a   Scheinfeld, Noah ^a  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

Acne; Adverse effects; Atridox ; Doryx ; Doxcycline; Doxycycline hyclate; ER minocycline; Minocycline; Periostat ; Safety; Tetracyclines; Vibramycin

Indexed keywords

ANTACID AGENT; ATRIDOX; DOXYCYCLINE; DOXYCYCLINE HYCLATE; IRON; METHOTREXATE; MINOCYCLINE; PLACEBO; TETRACYCLINE; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG; WARFARIN; ANTIINFECTIVE AGENT; DRUG DERIVATIVE;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ACNE; ANEMIA; ANTIBACTERIAL ACTIVITY; BEDTIME DOSAGE; BLOOD TOXICITY; BRAIN PSEUDOTUMOR; CANDIDIASIS; CLINICAL TRIAL; DECREASED APPETITE; DELAYED DRUG RELEASE; DIARRHEA; DIPLOPIA; DISTRIBUTION VOLUME; DIZZINESS; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG APPROVAL; DRUG CAPSULE; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG ERUPTION; DRUG INDICATION; DRUG INDUCED HEADACHE; DRUG PENETRATION; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; DRUG WITHDRAWAL; EOSINOPHILIA; ERYTHEMA; ESOPHAGITIS; ESOPHAGUS ULCER; ESSENTIAL HYPERTENSION; EXFOLIATIVE DERMATITIS; FATIGUE; FLU LIKE SYNDROME; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; GINGIVA DISEASE; GINGIVITIS; HEARTBURN; HEMOLYTIC ANEMIA; HICCUP; HUMAN; HYPERPIGMENTATION; HYPERTENSION; INFECTION; INFLUENZA; INSOMNIA; LETHARGY; LEUKEMOID REACTION; LIVER TOXICITY; MEDIASTINITIS; MYALGIA; MYCOSIS; NAUSEA; NEUTROPENIA; ONYCHOLYSIS; OSTEOLYSIS; PAPILLEDEMA; PERIODONTITIS; PHOTOPHOBIA; PHOTOSENSITIVITY; PHOTOTOXICITY; PREMENSTRUAL SYNDROME; PRURITUS; REVIEW; RHINOPHARYNGITIS; ROSACEA; SIDE EFFECT; SINUSITIS; SKIN DISEASE; STEVENS JOHNSON SYNDROME; STOMACH ULCER; STRUCTURE ACTIVITY RELATION; SYSTEMIC LUPUS ERYTHEMATOSUS; TABLET; THROMBOCYTOPENIA; TOOTH DISCOLORATION; TOOTH DISEASE; TOOTH PAIN; TOXIC HEPATITIS; UPPER RESPIRATORY TRACT INFECTION; VAGINITIS; VERTIGO; VESTIBULAR DISORDER; VOMITING; CHILD; DOSE RESPONSE; DRUG DOSAGE FORM; PERIODONTAL DISEASE;

ANTI-BACTERIAL AGENTS; CHILD; DOSAGE FORMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; HUMANS; PERIODONTAL DISEASES; TETRACYCLINES;

EID: 54449093463     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740338.7.5.571     Document Type: Review

References (26)

1. Meynadier J, Alirezai M. Systemic antibiotics for acne. Dermatology 1998;196:135-9
2. Vibramycin [package insert] New York N. Pfizer, Inc. 2007
3. Maibach H. Second-generation tetracyclines, a dermatologic overview: clinical uses and pharmacology therapeutics for the clinician: new reports on treatment modalities of possible interest to patient-caring physicians. Cutis 1991;48(5):411-7
4. DH official FDA information side effects and uses. Available from: http://www.drugs.com/tro/doxycline-hyclate.html
5. Hasan SA. Interaction of doxycycline and warfarin: an enhanced anticoagulant effect. Cornea 2007;26(6):742-3
6. Biller JA, Flores A, Buie T, et al. Tetracycline-induced esophagitis in adolescent patients. J Pediatr 1992;120:144-5
7. Tzianetas I, Haabal F, Keystone JS. Short report: severe hiccups secondary to doxycycline-induced esophagitis during treatment of malaria. Am J Trop Med Hyg 1996;54:203-4
8. Orr J, Pelel Y, Shahar A. Mediastinitis secondary to esophageal ulceration after doxycillin. Harefuah 1994;126(Suppl 4):193-4, 239
9. Simpson MB, Pryzbylik J, Innis B, Denham MA. Hemolytic anemia after tetracycline therapy. N Engl J Med 1985;312:840-2
10. Chatam WW,, Ross DW. Leukemoid blood reaction to tetracycline. South Med J 1983;76:1195-6
11. Pierog SH, Al Salihi FL, Cinotti D. Pseudotumor cerebri-a complication of tetracycline treatment of acne. J Adolesc Health Care 1986;7:139-40
12. Trueb RM, Burg G. Acute generalized exanthematous pustulosis due to doxycycline. Dermatology 1993; 186:75-8
13. Davies MG, Kersey PJW. Acute hepatitis and exfoliative dermatitis associated with minocycline. BMJ 1989;298:1523-4
14. Curley RK, Verbov JL. Stevens-Johns syndrome due to tetracyclines-a case report (doxycycline and a review of the literature. Clin Exp Dermatol 1987;12:124-5
15. Epstein JH, Seibert JS. Porphyriaplike curaneous changes induced by tetracycline hydrochloride photosensibilisation. Arch Dermatol 1976;112:661-6
16. Nelson, R, Parker SR. Ddxycycline-induced staining of adult teeth: the first reported case. Arch Dermatol 2006; 142(8): 1081-2
17. Cunha BA, Sibley CM, Ristuccia AM. Review doxycycline. Ther Drug Monit 1982;4:115-35
18. Berger RS. A double-blind, multiple-dose, placebo-controlled, cross-over study to compare the incidence of gi complaints in healthy subjects given Doryx R and Vibramycin R. J Clin Pharmacol 198;28:367-70
19. Skidmore R, Kovach R, Walker C, et al. Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne. Arch Dermatol 2003;139:459-64 doxycycline are effective and safe in treating acne and periodontitis.
20. Caton JG. Evaluation of periostat for patient management. Compend Contin Educ Dent 1000;20:451-62
21. Del Rosso JQ. A status report on the use of subantimicrobial-dose doxycycline: a review of the biologic and antimicrobial effects of the tetracyclines. Cutis 2004;74:118-22
22. Atridox (doxycycline hychte) 10% in the Atrigel Delivery Systempackage insert 0476 (Rev 7 2/03). Available from: http://www.fda.gov/cder/foi/ label/2003/50751 scs01l_atridox〈l.pdf
23. Wise RD. Submicrobial doxycycline and rosacea. Comp Ther 2007;332:78
24. Del Rosso JQ. Recently approved systemic therapies for acne vulgaris and rosacea. Cutis 2007;80:113-20
25. Del Rosso JQ, Webster GF, Jackson M, et al, Two randomized phase III clinical trials evaluating anti-inflammatory dose doxycycline (40 mg doxycycline, USP capsules) administered once daily for treatment of rosacea. J Am Acad Dermatol 2007;56:791-802
26. Fleischer AB Jr, Dinehart S, Stough D, et al.; for the Solodyn Phase 2 and Phase 3 Study Groups. Safety and efficacy of a new extended-release formulation of minocycline. Cutis 2006;78(Suppl 4):21-31