The influence of drift gas composition on the separation mechanism in traveling wave ion mobility spectrometry: Insight from electrodynamic simulations

International Journal for Ion Mobility Spectrometry

Volumn 16, Issue 2, 2013, Pages 85-94

  May, Jody C ^a   McLean, John A ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alternate drift gases; Argon; Electrodynamic ion simulations; Helium; Nitrogen; Traveling wave ion mobility spectrometry; TWIMS resolving power

Indexed keywords

ACOUSTIC WAVE VELOCITY; ARGON; ELECTRODYNAMICS; GASES; HELIUM; ION MOBILITY SPECTROMETERS; NITROGEN; RUTHERFORD BACKSCATTERING SPECTROSCOPY; SEPARATION; SPECTROMETRY; WAVE PROPAGATION;

COLLISIONAL SCATTERINGS; ELECTRODYNAMIC SIMULATIONS; ION SIMULATION; ION TRAJECTORY SIMULATIONS; SECOND GENERATION; SEPARATION MECHANISM; SIMULATION MODEL; TRAVELING WAVE ION MOBILITY SPECTROMETRIES;

IONS;

EID: 84876905112     PISSN: 14356163     EISSN: 18654584     Source Type: Journal    
DOI: 10.1007/s12127-013-0123-7     Document Type: Article

References (15)

1. Dwivedi P, Wu C, Matz L, Clowers BH, Siems WF, Hill HH Jr (2006) Gas-phase chiral separations by ion mobility spectrometry. Anal Chem 78(24): 8200-8206.
2. Giles K, Pringle SD, Worthington KR, Little D, Wildgoose JL, Bateman RH (2004) Applications of a traveling wave-based radio-frequency-only stacked ring ion guide. Rapid Commun Mass Spectrom 18(20): 2401-2414.
3. Giles K, Wildgoose JL, Langridge DJ, Campuzano I (2010) A method for direct measurement of ion mobilities using a travelling wave ion guide. Int J Mass Spectrom 298(1-3): 10-16.
4. Giles K, Williams JP, Campuzano I (2011) Enhancements in travelling wave ion mobility resolution. Rapid Commun Mass Spectrom 25(11): 1559-1566.
5. Howdle MD, Eckers C, Laures AMF, Creaser CS (2010) The effect of drift gas on the separation of active pharmaceutical ingredients and impurities by ion mobility-mass spectrometry. Int J Mass Spectrom 298(1-3): 72-77.
6. Knapman TW, Berryman JT, Campuzano I, Harris SA, Ashcroft AE (2010) Considerations in experimental and theoretical collision cross-section measurements of small molecules using travelling wave ion mobility spectrometry-mass spectrometry. Int J Mass Spectrom 298(1-3): 17-23.
7. Manura DJ (2012) SIMION 8. 1. 1. 14 incorporating the "Collision Model HS1" user program. LUA edn. Scientific Instrument Services, Inc., Ringoes, NJ.
8. Mason EA, Schamp HW (1958) Mobility of gaseous ions in weak electric fields. Ann Phys 4(3): 233-270.
9. Matz L, Hill H, Beegle L, Kanik I (2002) Investigation of drift gas selectivity in high resolution ion mobility spectrometry with mass spectrometry detection. J Am Soc Mass Spectrom 13(4): 300-307.
10. Pringle SD, Giles K, Wildgoose JL, Williams JP, Slade SE, Thalassinos K, Bateman RH, Bowers MT, Scrivens JH (2007) An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument. Int J Mass Spectrom 261(1): 1-12.
11. Reid Asbury G, Hill HH Jr (2000) Using different drift gases to change separation factors in ion mobility spectrometry. Anal Chem 72(3): 580-584.
12. Ruotolo BT, McLean JA, Gillig KJ, Russell DH (2004) Peak capacity of ion mobility mass spectrometry: the utility of varying drift gas polarizability for the separation of tryptic peptides. J Mass Spectrom 39(4): 361-367.
13. Rusyniak M, Ibrahim Y, Alsharaeh E, Meot-Ner M, El-Shall MS (2003) Mass-selected ion mobility studies of the isomerization of the benzene radical cation and binding energy of the benzene dimer cation. Separation of isomeric ions by Dimer Formation. J Phys Chem A 107(38): 7656-7666.
14. Shvartsburg AA, Smith RD (2008) Fundamentals of traveling wave ion mobility spectrometry. Anal Chem 80(24): 9689-9699.
15. Zhong Y, Hyung S-J, Ruotolo BT (2011) Characterizing the resolution and accuracy of a second-generation traveling-wave ion mobility separator for biomolecular ions. Analyst 136(17): 3534-3541.