Angiopoietin-2 expression is correlated with angiogenesis and overall survival in oral squamous cell carcinoma

Medical Oncology

Volumn 30, Issue 2, 2013, Pages

  Li, Chao ^a,b   Sun, Chang Jin ^c   Fan, Jin Chuan ^b   Geng, Ning ^a   Li, Chun Hua ^b   Liao, Jian ^d   Mi, Kun ^b   Zhu, Gui Quan ^b   Ma, Hong ^d   Song, Yu Feng ^d   Tang, Ya Ling ^a   Chen, Yu ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN CANCER HOSPITAL   (China)

^c Chengdu Third People's Hospital   (China)

^d GUIZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Angiopoietin 2; Microvessel density; Oral squamous cell carcinoma; VEGF; Vessel maturation index

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOPOIETIN 2; CD34 ANTIBODY; VASCULOTROPIN; TUMOR MARKER; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER GROWTH; CANCER PATIENT; CANCER SURVIVAL; CAPILLARY DENSITY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MATURATION; MOUTH SQUAMOUS CELL CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; BIOSYNTHESIS; CHEMISTRY; COHORT ANALYSIS; KAPLAN MEIER METHOD; METABOLISM; MICROVASCULATURE; MIDDLE AGED; MOUTH MUCOSA; MOUTH TUMOR; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; SQUAMOUS CELL CARCINOMA; VASCULARIZATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANGIOPOIETIN-2; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MICROVESSELS; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84876897644     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-013-0571-2     Document Type: Article

References (44)

1. Zygogianni AG, Kyrgias G, Karakitsos P, Psyrri A, Kouvaris J, Kelekis N, et al. Oral squamous cell cancer: early detection and the role of alcohol and smoking. Head Neck Oncol. 2011;3:2.
2. Li C, Chen JC, Wang ZH, Zhang B, Li B, Song YF. The characteristics and significance of microvessel in oral squamous cell carcinoma. Zhonghua Kou Qiang Yi Xue Za Zhi. 2007;42:70-3.
3. Li C, Feng HC, Chen JC, Song YF. Expression and significance of angiopoietin-1 and angiopoietin-2 in oral squamous cell carcinoma. Ai Zheng. 2005;24:1388-93.
4. Johnstone S, Logan RM. Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 2007;36:263-6.
5. Lopez-Graniel CM, Tamez de Leon D, Meneses-Garcia A, Gómez-Ruiz C, Frias-Mendivil M, Granados-García M, et al. Tumor angiogenesis as a prognostic factor in oral cavity carcinomas. Exp Clin Cancer Res. 2001;20:463-8.
6. Fagiani E, Christofori G. Angiopoietins in angiogenesis. Cancer Lett. 2013;328:18-26.
7. Sakurai T, Kudo M. Signaling pathways governing tumor angiogenesis. Oncology. 2011;1:24-9.
8. Saharinen P, Eklund L, Pulkki K, Bono P, Alitalo K. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med. 2011;17:347-62.
9. Johnstone S, Logan RM. The role of vascular endothelial growth factor (VEGF) in oral dysplasia and oral squamous cell carcinoma. Oral Oncol. 2006;42:337-42.
10. Asahara T, Chen D, Takahashi T, Fujikawa K, Kearney M, Magner M, et al. Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res. 1998;83:233-40.
11. Feng Y, vom Hagen F, Pfister F, Djokic S, Hoffmann S, Back W, et al. Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression. Thromb Haemost. 2007;97:99-108.
12. Thomas M, Augustin HG. The role of the angiopoietins in vascular morphogenesis. Angiogenesis. 2009;12:125-37.
13. Shim WSN, Ho IAW, Wong PEH. Angiopoietin A TIE(d) balance in tumor angiogenesis. Mol Cancer Res. 2007;5:655-65.
14. Koga K, Todaka T, Morioka M, Hamada J, Kai Y, Yano S, et al. Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis. Cancer Res. 2001;61:6248-54.
15. Ochiumi T, Tanaka S, Oka S, Hiyama T, Ito M, Kitadai Y, et al. Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma. Int J Oncol. 2004;24:539-47.
16. Ahmad SA, Liu W, Jung YD, Fan F, Wilson M, Reinmuth N, et al. The effects of angiopoietin-1 and -2on tumor growth and angiogenesis in human colon cancer. Cancer Res. 2001;61:1255-9.
17. Yoshida Y, Oshika Y, Fukushima Y, Tokunaga T, Hatanaka H, Kijima H, et al. Expression of angiostatic factors in colorectal cancer. Int J Oncol. 1999;15:1221-5.
18. Oka N, Yamamoto Y, Takahashi M, Nishitani M, Kanayama HO, Kagawa S. Expression of angiopoietin-1 and -2, and its clinical significance in human bladder cancer. BJU Int. 2005;95:660-3.
19. Tanaka F, Ishikawa S, Yanagihara K, Miyahara R, Kawano Y, Li M, et al. Expression of angiopoietins and its clinical significance in non-small cell lung cancer. Cancer Res. 2002;62:7124-9.
20. Helfrich I, Edler L, Sucker A, Thomas M, Christian S, Schadendorf D, et al. Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin Cancer Res. 2009;15:1384-92.
21. Yu Q, Stamenkovic I. Angiopoietin-2 is implicated in the regulation of tumor angiogenesis. Am J Pathol. 2001;158:563-70.
22. Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest. 1999;103:341-5.
23. Holash J, Maisonpierre PC, Compton D, Boland P, Alexander CR, Zagzag D, et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science. 1999;284:1994-8.
24. Wakui S, Yokoo K, Muto T, Suzuki Y, Takahashi H, Furusato M, et al. Localization of Ang-1, -2, Tie-2, and VEGF expression at endothelial-pericyte interdigitation in rat angiogenesis. Lab Invest. 2006;86:1172-84.
25. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17:1471-4.
26. Bryne M, Koppang HS, Lilleng R, Kjaerheim A. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol. 1992;166:375-81.
27. Eberhard A, Kahlert S, Goede V. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res. 2000;60:1388-93.
28. Koga K, Todaka T, Morioka M, Hamada J, Kai Y, Yano S, et al. Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis. Cancer Res. 2001;61:6248-54.
29. Ochiumi T, Tanaka S, Oka S, Hiyama T, Ito M, Kitadai Y, et al. Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma. Int J Oncol. 2004;24:539-47.
30. Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat. 1995;36:169-80.
31. He LL, Zhang WJ, Su H, Xu DG. Synergism between Ang-2 and VEGF and its application of anti-angiogenesis in tumor therapy. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007;15:445-8.
32. Mǎrgǎritescu C, Pirici D, Stîngǎ A, Simionescu C, Raica M, Mogoantǎ L, et al. VEGF expression and angiogenesis in oral squamous cell carcinoma: an immunohistochemical and morphometric study. Clin Exp Med. 2010;10:209-14.
33. Conklin LD, McAninch RE, Schulz D, Kaluza GL, LeMaire SA, Coselli JS, et al. HIV-based vectors and angiogenesis following rabbit hindlimb ischemia. J Surg Res. 2005;123:55-66.
34. Ley CD, Olsen MW, Lund EL, Kristjansen PE. Angiogenic synergy of bFGF and VEGF is antagonized by angiopoietin-2in a modified in vivo matrigel assay. Microvasc Res. 2004;68:161-8.
35. Machein MR, Knedla A, Knoth R, Wagner S, Neuschl E, Plate KH. Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. Am J Pathol. 2004;165:1557-70.
36. Etoh T, Inoue H, Tanaka S, Barnard GF, Kitano S, Mori M. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. Cancer Res. 2001;61:2145-53.
37. Chien CY, Su CY, Chuang HC, Fang FM, Huang HY, Chen CM, et al. Angiopoietin-1 and -2 expression in recurrent squamous cell carcinoma of the oral cavity. J Surg Oncol. 2008;97:273-7.
38. Cheng SJ, Lee JJ, Kok SH, Chou CH, Chang HH, Yang H, et al. Expression of vascular endothelial growth factor is significantly associated with progression and prognosis of oral squamous cell carcinomas in Taiwan. J Formos Med Assoc. 2011;110:50-7.
39. Chien CY, Su CY, Hwang CF, Chuang HC, Chen CM, Huang CC. High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis. Surg Oncol. 2006;94:413-7.
40. Shao Z, Zhang WF, Chen XM, Shang ZJ. Expression of EphA2 and VEGF in squamous cell carcinoma of the tongue: correlation with the angiogenesis and clinical outcome. Oral Oncol. 2008;44:1110-7.
41. Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat. 1995;36:169-80.
42. Zagzag D, Amirnovin R, Greco MA, Yee H, Holash J, Wiegand SJ, et al. Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis. Lab Invest. 2000;80:837-49.
43. Gee MS, Procopio WN, Makonnen S. Tumor vessel development and maturation impose limits on the effectiveness of anti-vascular therapy. Am J Pathol. 2003;162:183-93.
44. Chechlinska M, Kowalewska M, Nowak R. Systemic inflammation as a confounding factor in cancer biomarker discovery and validation. Nat Rev Cancer. 2010;10:2-3.