Visualization analysis of the vacuole-targeting fungicidal activity of amphotericin B against the parent strain and an ergosterol-less mutant of Saccharomyces cerevisiae

Microbiology (United Kingdom)

Volumn 159, Issue PART 5, 2013, Pages 939-947

  Kang, Chang Kyung ^a   Yamada, Keiichi ^b   Usuki, Yoshinosuke ^a   Ogita, Akira ^a   Fujita, Ken Ichi ^a   Tanaka, Toshio ^a  

^a Osaka Prefecture University   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; ERGOSTEROL; MC 12; UNCLASSIFIED DRUG;

ANTIFUNGAL RESISTANCE; ARTICLE; CELL DISRUPTION; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TARGETING; FLUORESCENCE; FUNGAL CELL; FUNGAL STRAIN; FUNGICIDAL ACTIVITY; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 84876888325     PISSN: 13500872     EISSN: 14652080     Source Type: Journal    
DOI: 10.1099/mic.0.065714-0     Document Type: Article

References (27)

1. Alonso, M. A., Vázquez, D. & Carrasco, L. (1979). Compounds affecting membranes that inhibit protein synthesis in yeast. Antimicrob Agents Chemother 16, 750-756.
2. Baginski, M., Sternal, K., Czub, J. & Borowski, E. (2005). Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic. Acta Biochim Pol 52, 655-658.
3. Borjihan, H., Ogita, A., Fujita, K., Hirasawa, E. & Tanaka, T. (2009). The vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans and its enhancement by allicin. J Antibiot (Tokyo) 62, 691-697.
4. Bourot, S. & Karst, F. (1995). Isolation and characterization of the Saccharomyces cerevisiae SUT1 gene involved in sterol uptake. Gene 165, 97-102.
5. Carrillo-Muñoz, A. J., Giusiano, G., Ezkurra, P. A. & Quindós, G. (2006). Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter 19, 130-139.
6. Davis, L. E., Shen, J. & Royer, R. E. (1994). In vitro synergism of concentrated Allium sativum extract and amphotericin B against Cryptococcus neoformans. Planta Med 60, 546-549.
7. Eliopoulos, G. M. & Moellering, R. C. (1991). Antimicrobial combinations. In Antibiotics in Laboratory Medicine, 3rd edn, pp. 432-492. Edited by V. Lorian. Baltimore, MD: Williams & Wilkins.
8. Kato, M. & Wickner, W. (2001). Ergosterol is required for the Sec18/ ATP-dependent priming step of homotypic vacuole fusion. EMBO J 20, 4035-4040.
9. Kim, J. H., Faria, N. C., Martins, M. L., Chan, K. L. & Campbell, B. C. (2012). Enhancement of antimycotic activity of amphotericin B by targeting the oxidative stress response of Candida and Cryptococcus with natural dihydroxybenzaldehydes. Front Microbiol 3, 261.
10. Kurono, M. & Isobe, M. (2004). Synthesis and physical nature of fluorescent photoaffinity probe for the bioorganic studies on tautomycin, a protein phosphatase type 1 selective inhibitor. Chem Lett 33, 452-453.
11. Martel, C. M., Parker, J. E., Bader, O., Weig, M., Gross, U., Warrilow, A. G., Kelly, D. E. & Kelly, S. L. (2010). A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14a-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Antimicrob Agents Chemother 54, 3578-3583.
12. Nakayama, K., Yamaguchi, T., Doi, T., Usuki, Y., Taniguchi, M. & Tanaka, T. (2002). Synergistic combination of direct plasma membrane damage and oxidative stress as a cause of antifungal activity of polyol macrolide antibiotic niphimycin. J Biosci Bioeng 94, 207-211.
13. 2+ and allicin, an allyl sulfur compound from garlic, and its relation to the role of alkyl hydroperoxide reductase 1 as a cell surface defense in Saccharomyces cerevisiae. Toxicology 215, 205-213.
14. Ogita, A., Fujita, K., Taniguchi, M. & Tanaka, T. (2006). Enhancement of the fungicidal activity of amphotericin B by allicin, an allyl-sulfur compound from garlic, against the yeast Saccharomyces cerevisiae as a model system. Planta Med 72, 1247-1250.
15. Ogita, A., Matsumoto, K., Fujita, K., Usuki, Y., Hatanaka, Y. & Tanaka, T. (2007). Synergistic fungicidal activities of amphotericin B and Nmethyl- N′-dodecylguanidine: a constituent of polyol macrolide antibiotic niphimycin. J Antibiot (Tokyo) 60, 27-35.
16. Ogita, A., Fujita, K. & Tanaka, T. (2009). Enhancement of the fungicidal activity of amphotericin B by allicin: effects on intracellular ergosterol trafficking. Planta Med 75, 222-226.
17. Ogita, A., Fujita, K., Usuki, Y. & Tanaka, T. (2010a). Targeted yeast vacuole disruption by polyene antibiotics with a macrocyclic lactone ring. Int J Antimicrob Agents 35, 89-92.
18. Ogita, A., Yutani, M., Fujita, K. & Tanaka, T. (2010b). Dependence of vacuole disruption and independence of potassium ion efflux in fungicidal activity induced by combination of amphotericin B and allicin against Saccharomyces cerevisiae. J Antibiot (Tokyo) 63, 689-692.
19. Ogita, A., Fujita, K. & Tanaka, T. (2012). Enhancing effects on vacuole-targeting fungicidal activity of amphotericin B. Front Microbiol 3, 100.
20. Ramotowski, S. & Szcześniak, M. (1967). [Determination of potassium salt content in pharmaceutical preparations by means of sodium tetraphenylborate]. Acta Pol Pharm 24, 605-613 (in Polish).
21. Sanglard, D., Ischer, F., Parkinson, T., Falconer, D. & Bille, J. (2003). Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. Antimicrob Agents Chemother 47, 2404-2412.
22. Tanaka, T., Nakayama, K., Machida, K. & Taniguchi, M. (2000). Longchain alkyl ester of AMP acts as an antagonist of glucose-induced signal transduction that mediates activation of plasma membrane protein pump in Saccharomyces cerevisiae. Microbiology 146, 377-384.
23. Usuki, Y., Matsumoto, K., Inoue, T., Yoshioka, K., Iio, H. & Tanaka, T. (2006). Structure-activity relationship studies on niphimycin, a guanidylpolyol macrolide antibiotic. Part 1: the role of the Nmethyl- N0-alkylguanidium moiety. Bioorg Med Chem Lett 16, 1553-1556.
24. Vida, T. A. & Emr, S. D. (1995). A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. J Cell Biol 128, 779-792.
25. Yamaji, N., Matsumori, N., Matsuoka, S., Oishi, T. & Murata, M. (2002). Amphotericin B dimers with bisamide linkage bearing powerful membrane-permeabilizing activity. Org Lett 4, 2087-2089.
26. Young, L. Y., Hull, C. M. & Heitman, J. (2003). Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. Antimicrob Agents Chemother 47, 2717-2724.
27. Yutani, M., Ogita, A., Usuki, Y., Fujita, K. & Tanaka, T. (2011). Enhancement effect of N-methyl-N0-dodecylguanidine on the vacuole- targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans. J Antibiot (Tokyo) 64, 469-474.