Synthesis and physical nature of fluorescent photoaffinity probe for the bioorganic studies on tautomycin, a protein phosphatase type 1 selective inhibitor

Chemistry Letters

Volumn 33, Issue 4, 2004, Pages 452-453

  Kurono, Masakuni ^b   Isobe, Minoru ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; FUNCTIONAL GROUP; MALEIC ACID; ORGANIC COMPOUND; PEPTIDE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; TAUTOMYCIN;

ARTICLE; CONFORMATION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR PROBE; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PHOTOAFFINITY LABELING; PHOTOREACTIVITY; SYNTHESIS;

EID: 3142781596     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2004.452     Document Type: Article

References (15)

1. For structure of tautomycin, see: a) M. Ubukata, X.-C. Cheng, and K. Isono, J. Chem. Soc., Chem. Commun., 1990, 244. b) X.-C. Cheng, M. Ubukata, and K. Isono, J. Antibiot., 43, 809 (1990). c) M. Ubukata, X.-C. Cheng, M. Isobe, and K. Isono, J. Chem. Soc., Perkin Trans. 1, 1993, 617.
2. For structure of tautomycin, see: a) M. Ubukata, X.-C. Cheng, and K. Isono, J. Chem. Soc., Chem. Commun., 1990, 244. b) X.-C. Cheng, M. Ubukata, and K. Isono, J. Antibiot., 43, 809 (1990). c) M. Ubukata, X.-C. Cheng, M. Isobe, and K. Isono, J. Chem. Soc., Perkin Trans. 1, 1993, 617.
3. For structure of tautomycin, see: a) M. Ubukata, X.-C. Cheng, and K. Isono, J. Chem. Soc., Chem. Commun., 1990, 244. b) X.-C. Cheng, M. Ubukata, and K. Isono, J. Antibiot., 43, 809 (1990). c) M. Ubukata, X.-C. Cheng, M. Isobe, and K. Isono, J. Chem. Soc., Perkin Trans. 1, 1993, 617.
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10. +); found 367.1499.
11. +); found 1367.6808.
12. Computer calculation was carried out on a Silicon Graphics Octan computer. Energy-minimization was performed on 10,000 initial starting conformations with global minimum search program using Macromodel version 7.1 with MMFF force filed. a) F. Mohamadi, N. G. J. Richards, W. C. Guida, R. Liskamp, M. Lipton, C. Caufield, G. Chang, T. Hendrickson, and W. C. Still, J. Comput. Chem., 11, 440 (1990). b) T. A. Halgren, J. Comput. Chem., 20, 730 (1999), and references cited therein.
13. Computer calculation was carried out on a Silicon Graphics Octan computer. Energy-minimization was performed on 10,000 initial starting conformations with global minimum search program using Macromodel version 7.1 with MMFF force filed. a) F. Mohamadi, N. G. J. Richards, W. C. Guida, R. Liskamp, M. Lipton, C. Caufield, G. Chang, T. Hendrickson, and W. C. Still, J. Comput. Chem., 11, 440 (1990). b) T. A. Halgren, J. Comput. Chem., 20, 730 (1999), and references cited therein.
14. 2+); found 686.332.
15. 2+); found 687.341.