Diet-Induced Obesity Exacerbates Auditory Degeneration via Hypoxia, Inflammation, and Apoptosis Signaling Pathways in CD/1 Mice

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Hwang, Juen Haur ^a,b,c   Hsu, Chuan Jen ^d   Yu, Wei Hsuan ^a   Liu, Tien Chen ^d   Yang, Wei Shiung ^a,d,e  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c TZU CHI UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; HYPOXIA INDUCIBLE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUDITORY DEGENERATION; AUDITORY RESPONSE; BIOCHEMISTRY; BLOOD VESSEL; BODY WEIGHT; CELL DENSITY; COCHLEA; CONTROLLED STUDY; DIET; DIET RESTRICTION; DISEASE EXACERBATION; HEARING DISORDER; HISTOPATHOLOGY; HYPOXIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID DIET; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; OBESITY; OMENTUM; SPIRAL GANGLION; SPIRAL LIGAMENT; STRIA VASCULARIS; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; ANOXIA; COMPLICATION; DISEASE COURSE; HEARING LOSS; PATHOLOGY; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; ANOXIA; APOPTOSIS; COCHLEA; DIET; DISEASE PROGRESSION; HEARING LOSS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICE; OBESITY; SIGNAL TRANSDUCTION;

EID: 84876884340     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060730     Document Type: Article

References (39)

1. Evans MB, Tonini R, Shope CD, Oghalai JS, Jerger JF, et al. (2006) Dyslipidemia and auditory function. Otol Neurotol. 27: 609-614.
2. Frisina ST, Mapes F, Kim S, Frisina DR, Frisina RD, (2006) Characterization of hearing loss in aged type II diabetics. Hear Res. 211: 103-113.
3. Friedland DR, Cederberg C, Tarima S, (2009) Audiometric pattern as a predictor of cardiovascular status: development of a model for assessment of risk. Laryngoscope 119: 473-486.
4. Hwang JH, Chen JC, Hsu CJ, Liu TC, (2011) Association of obstructive sleep apnea and auditory dysfunctions in older subjects. Otolaryngol Head Neck Surg 144: 114-119.
5. Hwang JH, Ho HC, Hsu MC, Chen JC, (2011) Effect of transient ischemic attack on hearing thresholds of older subjects. Audiol Neurotol EXTRA 1: 1-8.
6. Fransen E, Topsakal V, Hendrickx JJ, Van Laer L, Huyghe JR, et al. (2008) Occupational Noise, Smoking, and a High Body Mass Index are Risk Factors for Age-related Hearing Impairment and Moderate Alcohol Consumption is Protective: A European Population-based Multicenter Study. J Assoc Res Otolaryngol. 9: 264-276.
7. Hwang JH, Wu CC, Hsu CJ, Liu TC, Yang WS, (2009) Association of central obesity with the severity and audiometric configurations of age-related hearing impairment. Obesity 17: 1796-1801.
8. Jackson AW, Lee DC, Sui X, Morrow JR Jr, Church TS, et al. (2010) Muscular Strength Is Inversely Related to Prevalence and Incidence of Obesity in Adult Men. Obesity 18: 1988-1995.
9. Kabrhel C, Varraso R, Goldhaber SZ, Rimm EB, Camargo CA, (2009) Prospective Study of BMI and the Risk of Pulmonary Embolism in Women. Obesity 17: 2040-2046.
10. Schaffer JE, (2003) Lipotoxicity: when tissues overeat. Curr Opin Lipidol. 14: 281-287.
11. Maestre I, Jordán J, Calvo S, Reig JA, Ceña V, et al. (2003) Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1. Endocrinology 144: 335-345.
12. Shone G, Raphael Y, Miller JM, (1991) Hereditary deafness occurring in cd/1 mice. Hear Res. 57: 153-156.
13. Riva C, Donadieu E, Magnan J, Lavieille JP, (2007) Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea. Exp Gerontol. 42: 327-336.
14. Wu T, Marcus DC, (2003) Age-related changes in cochlear endolymphatic potassium and potential in CD-1 and CBA/CaJ mice. J Assoc Res Otolaryngol. 4: 353-362.
15. Lin YS, Chen CM, Soong BW, Wu YR, Chen HM, et al. (2011) Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease. J CLIN INVEST. 121: 1519-1523.
16. Lin YH, Wu CC, Hsu CJ, Hwang JH, Liu TC, (2011) The grainyhead-like 2 gene (GRHL2) single nucleotide polymorphism is not associated with age-related hearing impairment in Han Chinese. Laryngoscope. 121(6): 1303-1307.
17. Van Eyken E, Van Camp G, Van Laer L, (2007) The complexity of age-related hearing impairment: contributing environmental and genetic factors. Audiol Neurootol 12: 345-358.
18. Hwang JH, Hsu CJ, Liu TC, Yang WS, (2011) Association of plasma adiponectin levels with hearing thresholds in adults. Clin Endocrinol (Oxf). 75: 614-620.
19. Lee HS, Kim KR, Chung WH, Cho YS, Hong SH, (2008) Early sensorineural hearing loss in ob/ob mouse, an animal model of type 2 diabetes. Clin Exp Otorhinolaryngol. 1: 211-216.
20. Lindstrom P, (2007) The physiology of obese-hyperglycemic mice [ob/ob mice]. Scientific World Journal. 7: 666-685.
21. Vasilyeva ON, Frisina ST, Zhu X, Walton JP, Frisina RD, (2009) Interactions of hearing loss and Diabetes Mellitus in the middle age CBA/CaJ mouse model of presbycusis. Hear Res. 249(1-2): 44-53.
22. Hidaka T (1997) Scanning and transmission electron microscopic observations of the inner ear of hamsters with hyperlipidemia. Nippon Jibiinkoka Gakkai Kaiho. 100: 900-908. [Article in Japanese].
23. Sikora MA, Morizono T, Ward WD, Paparella MM, Leslie K, (1986) Diet-induced hyperlipidemia and auditory dysfunction. Acta Otolaryngol. 102: 372-381.
24. Nicholson A, Reifsnyder PC, Malcolm RD, Lucas CA, MacGregor GR, et al. (2010) Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene. Obesity 18: 1902-1905.
25. Madsen AN, Hansen G, Paulsen SJ, Lykkegaard K, Tang-Christensen M, et al. (2010) Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome. J Endocrinol. 206: 287-296.
26. Cho BB, Toledo-Pereyra LH, (2008) Caspase-independent programmed cell death following ischemic stroke. J Invest Surg. 21: 141-147.
27. Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, et al. (2000) Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297: 259-263.
28. Mizukoshi S, Nakazawa M, Sato K, Ozaki T, Metoki T, et al. (2010) Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration. Exp Eye Res. 91: 353-361.
29. Park SY, Kim HY, Lee JH, Yoon KH, Chang MS, et al. (2010) The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle. Cell Mol Biol Lett. 15: 1-12.
30. Chung SH, Calafiore M, Plane JM, Pleasure DE, Deng W, (2011) Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration. Neurobiol Dis. 41: 445-457.
31. Engel T, Caballero-Caballero A, Schindler CK, Plesnila N, Strasser A, et al. (2010) BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor. J Neurochem. 115: 92-101.
32. Nakka VP, Gusain A, Mehta SL, Raghubir R, (2008) Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities. Mol Neurobiol. 37: 7-38.
33. Schulz JB, (2006) Anti-apoptotic gene therapy in Parkinson's disease. J Neural Transm Suppl. 70: 467-476.
34. Cottet S, Schorderet DF, (2009) Mechanisms of apoptosis in retinitis pigmentosa. Curr Mol Med. 9: 375-383.
35. Mittra S, Bansal VS, Bhatnagar PK, (2008) From a glucocentric to a lipocentric approach towards metabolic syndrome. Drug Discov Today. 13: 211-218.
36. Cohen AH, (1975) Massive obesity and the kidney. A morphologic and statistical study. Am J Pathol 81: 117-130.
37. Reynolds K, Gu D, Muntner P, Chen J, Wu X, et al. (2007) Body mass index and risk of ESRD in China. Am J Kidney Dis 50: 754-764.
38. Chou CL, Fang TC, (2010) Incidental chronic kidney disease in metabolic syndrome. Tzu Chi Med J 22: 11-17.
39. McQueen CT, Baxter A, Smith TL, Raynor E, Yoon SM, et al. (1999) Non-insulin-dependent diabetic microangiopathy in the inner ear. J Laryngol Otol. 113: 13-18.