Clinical implications from drug-drug and drug-disease interactions in older people

Clinical and Experimental Pharmacology and Physiology

Volumn 40, Issue 5, 2013, Pages 320-325

  Gnjidic, Danijela ^a   Johnell, Kristina ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Clinical outcomes; Drug disease interactions; Drug drug interactions; Older people; Prevalence

Indexed keywords

DRUG EXPOSURE; DRUG INTERACTION; GERIATRICS; HUMAN; NURSING HOME PATIENT; PREVALENCE; REVIEW; SYSTEMATIC REVIEW (TOPIC);

AGING; DRUG INTERACTIONS; HEALTH STATUS; HUMANS; PRESCRIPTION DRUGS;

EID: 84876872563     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/1440-1681.12081     Document Type: Review

References (57)

1. Marengoni A, Angleman S, Melis R et al. Aging with multimorbidity: A systematic review of the literature. Ageing Res. Rev. 2011; 10: 430-9.
2. Johnell K, Fastbom J. Comparison of prescription drug use between community-dwelling and institutionalized elderly in Sweden. Drugs Aging 2012; 29: 751-8.
3. Hines LE, Murphy JE. Potentially harmful drug-drug interactions in the elderly: A review. Am. J. Geriatr. Pharmacother. 2011; 9: 364-77.
4. Lindblad CI, Hanlon JT, Gross CR et al. Clinically important drug-disease interactions and their prevalence in older adults. Clin. Ther. 2006; 28: 1133-43.
5. Hilmer SN, Gnjidic D. The effects of polypharmacy in older adults. Clin. Pharmacol. Ther. 2009; 85: 86-8.
6. Hilmer SN, Gnjidic D, Abernethy DR. Pharmacoepidemiology in the postmarketing assessment of the safety and efficacy of drugs in older adults. J. Gerontol. A Biol. Sci. Med. Sci. 2012; 67: 181-8.
7. Haider SI, Johnell K, Thorslund M, Fastbom J. Trends in polypharmacy and potential drug-drug interactions across educational groups in elderly patients in Sweden for the period 1992-2002. Int. J. Clin. Pharmacol. Ther. 2007; 45: 643-53.
8. Becker ML, Kallewaard M, Caspers PW, Visser LE, Leufkens HG, Stricker BH. Hospitalisations and emergency department visits due to drug-drug interactions: A literature review. Pharmacoepidemiol. Drug Saf. 2007; 16: 641-51.
9. Lindley CM, Tully MP, Paramsothy V, Tallis RC. Inappropriate medication is a major cause of adverse drug reactions in elderly patients. Age Ageing 1992; 21: 294-300.
10. Hohl CM, Dankoff J, Colacone A, Afilalo M. Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Ann. Emerg. Med. 2001; 38: 666-71.
11. Bero LA, Lipton HL, Bird JA. Characterization of geriatric drug-related hospital readmissions. Med. Care 1991; 29: 989-1003.
12. Courtman BJ, Stallings SB. Characterization of drug-related problems in elderly patients on admission to a medical ward. Can. J. Hosp. Pharm. 1995; 48: 161-6.
13. Doucet J, Chassagne P, Trivalle C et al. Drug-drug interactions related to hospital admissions in older adults: A prospective study of 1000 patients. J. Am. Geriatr. Soc. 1996; 44: 944-8.
14. Malone DC, Abarca J, Hansten PD et al. Identification of serious drug-drug interactions: Results of the partnership to prevent drug-drug interactions. J. Am. Pharm. Assoc. 2004; 44: 142-51.
15. Johnell K, Klarin I. The relationship between number of drugs and potential drug-drug interactions in the elderly A study of over 600 000 elderly patients from the Swedish Prescribed Drug Register. Drug Saf. 2007; 30: 911-8.
16. Abarca J, Malone DC, Armstrong EP et al. Concordance of severity ratings provided in four drug interaction compendia. J. Am. Pharm. Assoc. 2004; 44: 136-41.
17. Vitry AI. Comparative assessment of four drug interaction compendia. Br. J. Clin. Pharmacol. 2007; 63: 709-14.
18. Haasum Y, Fastbom J, Johnell K. Institutionalization as a risk factor for inappropriate drug use in the elderly: A Swedish nationwide register-based study. Ann. Pharmacother. 2012; 46: 339-46.
19. Olsson J, Bergman A, Carlsten A et al. Quality of drug prescribing in elderly people in nursing homes and special care units for dementia: A cross-sectional computerized pharmacy register analysis. Clin. Drug. Investig. 2010; 30: 289-300.
20. Gnjidic D, Hilmer SN. Use of potentially inappropriate medications in the care of frail older people. Aging Health 2010; 6: 705-16.
21. Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults. Results of a US consensus panel of experts. Arch. Intern. Med. 2003; 163: 2716-24.
22. McLeod PJ, Huang AR, Tamblyn RM, Gayton DC. Defining inappropriate practices in prescribing for elderly people: A national consensus panel. CMAJ 1997; 156: 385-91.
23. Gallagher P, Ryan C, Byrne S, Kennedy J, O'Mahony D. STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int. J. Clin. Pharmacol. Ther. 2008; 46: 72-83.
24. Hanlon JT, Schmader KE, Samsa GP et al. A method for assessing drug therapy appropriateness. J. Clin. Epidemiol. 1992; 45: 1045-51.
25. Spinewine A, Schmader KE, Barber N et al. Appropriate prescribing in elderly people: How well can it be measured and optimised? Lancet 2007; 370: 173-84.
26. Aparasu RR, Mort JR. Inappropriate prescribing for the elderly: Beers criteria-based review. Ann. Pharmacother. 2000; 34: 338-46.
27. Roughead EE, Kalisch LM, Barratt JD, Gilbert AL. Prevalence of potentially hazardous drug interactions amongst Australian veterans. Br. J. Clin. Pharmacol. 2010; 70: 252-7.
28. Bjorkman IK, Fastbom J, Schmidt IK, Bernsten CB. Drug-drug interactions in the elderly. Ann. Pharmacother. 2002; 36: 1675-81.
29. Miller G, Britt H, Valenti L. Adverse drug events in general practice patients in Australia. Med. J. Aust. 2006; 184: 321-4.
30. Roughead EE, Barratt JD, Gilbert AL. Medication-related problems commonly occurring in an Australian community setting. Pharmacoepidemiol. Drug Saf. 2004; 13: 83-7.
31. Chrischilles EA, VanGilder R, Wright K, Kelly M, Wallace RB. Inappropriate medication use as a risk factor for self-reported adverse drug effects in older adults. J. Am. Geriatr. Soc. 2009; 57: 1000-6.
32. Hanlon JT, Sloane RJ, Pieper CF, Schmader KE. Association of adverse drug reactions with drug-drug and drug-disease interactions in frail older outpatients. Age Ageing 2011; 40: 274-7.
33. Johnell K, Weitoft GR, Fastbom J. Sex differences in inappropriate drug use. A register-based study of over 600 000 older people. Ann. Pharmacother. 2009; 43: 1233-8.
34. Lund BC, Carnahan RM, Egge JA, Chrischilles EA, Kaboli PJ. Inappropriate prescribing predicts adverse drug events in older adults. Ann. Pharmacother. 2010; 44: 957-63.
35. Nobili A, Pasina L, Tettamanti M et al. Potentially severe drug interactions in elderly outpatients: Results of an observational study of an administrative prescription database. J. Clin. Pharm. Ther. 2009; 34: 377-86.
36. Bergendal L, Friberg A, Schaffrath A. Potential drug-drug interactions in 5, 125 mostly elderly out-patients in Gothenburg Sweden. Pharm. World Sci. 1995; 17: 152-7.
37. Hosia-Randell HM, Muurinen SM, Pitkala KH. Exposure to potentially inappropriate drugs and drug-drug interactions in elderly nursing home residents in Helsinki, Finland: A cross-sectional study. Drugs Aging 2008; 25: 683-92.
38. Dolton MJ, Pont L, Stevens G, Mclachlan AJ. Prevalence of potentially harmful drug interactions in older people in Australian aged-care facilities. J. Pharm. Pract. Res. 2012; 42: 33-6.
39. Liao HL, Chen JT, Ma TC, Chang YS. Analysis of drug-drug interactions (DDIs) in nursing homes in central Taiwan. Arch. Gerontol. Geriatr. 2008; 47: 99-107.
40. Halvorsen KH, Granas AG, Engeland A, Ruths S. Prescribing quality for older people in Norwegian nursing homes and home nursing services using multidose dispensed drugs. Pharmacoepidemiol. Drug Saf. 2012; 21: 929-36.
41. Bergman A, Olsson J, Carlsten A, Waern M, Fastbom J. Evaluation of the quality of drug therapy among elderly patients in nursing homes. Scand. J. Prim. Health Care 2007; 25: 9-14.
42. Gallagher PF, O'Connor MN, O'Mahony D. Prevention of potentially inappropriate prescribing for elderly patients: A randomized controlled trial using STOPP/START criteria. Clin. Pharmacol. Ther. 2011; 89: 845-54.
43. Egger SS, Drewe J, Schlienger RG. Potential drug-drug interactions in the medication of medical patients at hospital discharge. Eur. J. Clin. Pharmacol. 2003; 58: 773-8.
44. Hassan F, Taylor D, Leow F, Doolan G, Knott J. Potential interactions between drugs taken by emergency department patients of an Australian hospital. J. Pharm. Pract. 2006; 36: 266-70.
45. Zakrzewski-Jakubiak H, Doan J, Lamoureux P, Singh D, Turgeon J, Tannenbaum C. Detection and prevention of drug-drug interactions in the hospitalized elderly: Utility of new cytochrome p450-based software. Am. J. Geriatr. Pharmacother. 2011; 9: 461-70.
46. Bakken MS, Ranhoff AH, Engeland A, Ruths S. Inappropriate prescribing for older people admitted to an intermediate-care nursing home unit and hospital wards. Scand. J. Prim. Health Care 2012; 30: 169-75.
47. Pugh MJ, Starner CI, Amuan ME et al. Exposure to potentially harmful drug-disease interactions in older community-dwelling veterans based on the healthcare effectiveness data and information set quality measure: Who is at risk? J. Am. Geriatr. Soc. 2011; 59: 1891-8.
48. Gellad WF, Good CB, Amuan ME, Marcum ZA, Hanlon JT, Pugh MJ. Facility-level variation in potentially inappropriate prescribing for older veterans. J. Am. Geriatr. Soc. 2012; 60: 1222-9.
49. Lindblad CI, Artz MB, Pieper CF et al. Potential drug-disease interactions in frail, hospitalized elderly veterans. Ann. Pharmacother. 2005; 39: 412-7.
50. Inouye SK, Studenski S, Tinetti ME, Kuchel GA. Geriatric syndromes: Clinical, research, and policy implications of a core geriatric concept. J. Am. Geriatr. Soc. 2007; 55: 780-91.
51. Siddiqi N, House AO, Holmes JD. Occurrence and outcome of delirium in medical in-patients: A systematic literature review. Age Ageing 2006; 35: 350-64.
52. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: Evidence for a phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 2001; 56: M146-56.
53. Gnjidic D, Hilmer SN, Blyth F et al. High risk prescribing and incidence of frailty among older community-dwelling men. Clin. Pharmacol. Ther. 2012; 91: 521-8.
54. Wilson NM, Hilmer SN, March LM et al. Associations between Drug Burden Index and falls in older people in residential aged care. J. Am. Geriatr. Soc. 2011; 59: 875-80.
55. Gnjidic D, Hilmer S, Le Couteur D. High risk prescribing in older adults: More harm than good? Aging Health 2012; 8: 325-7.
56. Hilmer SN, Gnjidic D, Le Couteur DG. Thinking through the medication list: Appropriate prescribing and deprescribing in robust and frail older patients. Aust. Fam. Physician 2012; 41: 924-8.
57. Cerreta F, Eichler HG, Rasi G. Drug policy for an aging population: The European Medicines Agency's geriatric medicines strategy. N. Engl. J. Med. 2012; 367: 1972-4.