N -Methyldihydroquinazolinone derivatives of retro-2 with enhanced efficacy against shiga toxin

Journal of Medicinal Chemistry

Volumn 56, Issue 8, 2013, Pages 3404-3413

  Noel, Romain ^a   Gupta, Neetu ^a   Pons, Valérie ^a   Goudet, Amélie ^a   Garcia Castillo, Maria Daniela ^b   Michau, Aurélien ^a   Martinez, Jennifer ^a   Buisson, David Alexandre ^a   Johannes, Ludger ^b   Gillet, Daniel ^a   Barbier, Julien ^a   Cintrat, Jean Christophe ^a  

^a DIF   (France)

^b INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 2 (5 METHYLTHIOPHEN 2 YL) 3 PHENYL 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 1 METHYL 2 [5 (2 METHYLTHIAZOL 4 YL)THIOPHEN 2 YL] 3 PHENYL 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (5 ETHYLTHIOPHEN 2 YL) 1 METHYL 3 PHENYL 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (5 ETHYLTHIOPHEN 2 YL) 3 PHENYL 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 [5 (2 METHYLTHIAZOL 4 YL)THIOPHEN 2 YL] 3 PHENYL 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; ANTITOXIN; CELL PROTEIN; N METHYLDIHYDROQUINAZOLINONE DERIVATIVE; QUINAZOLINONE DERIVATIVE; RETRO 2; SHIGA TOXIN; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; ENDOSOME; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTRACELLULAR TRANSPORT; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION; TRANS GOLGI NETWORK;

BENZAMIDES; BIOLOGICAL TRANSPORT; ENDOSOMES; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; QUINAZOLINONES; SHIGA TOXIN; SHIGA TOXINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84876864878     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4002346     Document Type: Article

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