Strictly lobar microbleeds are associated with executive impairment in patients with ischemic stroke or transient ischemic attack

Stroke

Volumn 44, Issue 5, 2013, Pages 1267-1272

  Gregoire, Simone M ^a   Scheffler, Grit ^a,d   Jäger, Hans R ^b   Yousry, Tarek A ^b   Brown, Martin M ^a   Kallis, Constantinos ^e   Cipolotti, Lisa ^c   Werring, David J ^a  

^a Stroke Research Group   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

cognition; microbleeds; MRI; stroke

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TRANSIENT ISCHEMIC ATTACK; VASCULAR AMYLOIDOSIS; WHITE MATTER;

ADULT; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; EXECUTIVE FUNCTION; FEMALE; HUMANS; INTRACRANIAL HEMORRHAGES; ISCHEMIC ATTACK, TRANSIENT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; STROKE;

EID: 84876853790     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.000245     Document Type: Article

References (37)

1. Wentzel C, Rockwood K, MacKnight C, Hachinski V, Hogan DB, Feldman H, et al. Progression of impairment in patients with vascular cognitive impairment without dementia. Neurology. 2001;57:714-716.
2. A united approach to vascular disease and neurodegeneration. Lancet Neurol. 2012;11:293.
3. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. Am J Neuroradiol. 1999;20:637-642.
4. Cordonnier C, van der Flier WM, Sluimer JD, Leys D, Barkhof F, Scheltens P. Prevalence and severity of microbleeds in a memory clinic setting. Neurology. 2006;66:1356-1360.
5. Goos JD, Kester MI, Barkhof F, Klein M, Blankenstein MA, Scheltens P, et al. Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fuid biomarkers and cognition. Stroke. 2009;40:3455-3460.
6. Werring DJ, Frazer DW, Coward LJ, Losseff NA, Watt H, Cipolotti L, et al. Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI. Brain. 2004;127:2265-2275.
7. Yakushiji Y, Nishiyama M, Yakushiji S, Hirotsu T, Uchino A, Nakajima J, et al. Brain microbleeds and global cognitive function in adults without neurological disorder. Stroke. 2008;39:3323-3328.
8. Seo SW, Hwa Lee B, Kim EJ, Chin J, Sun Cho Y, Yoon U, et al. Clinical signifcance of microbleeds in subcortical vascular dementia. Stroke. 2007;38:1949-1951.
9. Poels MM, Vernooij MW, Ikram MA, Hofman A, Krestin GP, van der Lugt A, et al. Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study. Stroke. 2010;41:S103-S106.
10. Fisher M. The challenge of mixed cerebrovascular disease. Ann N Y Acad Sci. 2010;1207:18-22.
11. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classifcation of subtype of acute ischemic stroke. Defnitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41.
12. Gregoire SM, Chaudhary UJ, Brown MM, Yousry TA, Kallis C, Jäger HR, et al. The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds. Neurology. 2009;73:1759-1766.
13. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjögren M, et al.; European Task Force on Age-Related White Matter Changes. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke. 2001;32:1318-1322.
14. Vermeer SE, Longstreth WT Jr, Koudstaal PJ. Silent brain infarcts: a systematic review. Lancet Neurol. 2007;6:611-619.
15. Trennary M. Stroop Neuropsychological Screening Test (snst). Odessa, FL: Psychological Assessment Resources Inc.; 1989.
16. Spreen O. Neurosensory Center Comprehensive Examination for Aphasia. Victoria, BC: Neuropsychology Laboratory, University of Victoria;1969.
17. Battery AIT. Manual and Directions for Scoring. Washington, DC: War Department, Adjunct General's Office;1944.
18. Weigl E. On the psychology of so-called processes of abstraction. J Abnormal Soc Psychol 1941;36:3-33.
19. Nelson HE. A modifed card sorting test sensitive to frontal lobe defects. Cortex. 1976;12:313-324.
20. Qiu C, Cotch MF, Sigurdsson S, Jonsson PV, Jonsdottir MK, Sveinbjrnsdottir S, et al. Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study. Neurology. 2010;75:2221-2228.
21. van Norden AG, van den Berg HA, de Laat KF, Gons RA, van Dijk EJ, de Leeuw FE. Frontal and temporal microbleeds are related to cognitive function: the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) Study. Stroke. 2011;42:3382-3386.
22. Poels MM, Ikram MA, van der Lugt A, Hofman A, Niessen WJ, Krestin G P, et al. Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology. 2012;78:326-333.
23. Werring DJ, Gregoire SM, Cipolotti L. Cerebral microbleeds and vascular cognitive impairment. J Neurol Sci. 2010;299:131-135.
24. Werring DJ, Coward LJ, Losseff NA, Jäger HR, Brown MM. Cerebral microbleeds are common in ischemic stroke but rare in TIA. Neurology. 2005;65:1914-1918.
25. Yamada S, Saiki M, Satow T, Fukuda A, Ito M, Minami S, et al. Periventricular and deep white matter leukoaraiosis have a closer association with cerebral microbleeds than age. Eur J Neurol. 2012;19:98-104.
26. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology. 2008;70:1208-1214.
27. Charidimou A, Gang Q, Werring DJ. Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J Neurol Neurosurg Psychiatr. 2012;83:124-137.
28. Pfeifer LA, White LR, Ross GW, Petrovitch H, Launer LJ. Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study. Neurology. 2002;58:1629-1634.
29. Greenberg SM, Eng JA, Ning M, Smith EE, Rosand J. Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke. 2004;35:1415-1420.
30. Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, et al.; Medical Research Council Cognitive Function and Aging Study. Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience. J Alzheimers Dis. 2011;25:359-372.
31. Arvanitakis Z, Leurgans SE, Wang Z, Wilson RS, Bennett DA, Schneider JA. Cerebral amyloid angiopathy pathology and cognitive domains in older persons. Ann Neurol. 2011;69:320-327.
32. Iadecola C, Park L, Capone C. Threats to the mind: aging, amyloid, and hypertension. Stroke. 2009;40:S40-S44.
33. Gregoire SM, Charidimou A, Gadapa N, Dolan E, Antoun N, Peeters A, et al. Acute ischaemic brain lesions in intracerebral haemorrhage: multicentre cross-sectional magnetic resonance imaging study. Brain. 2011;134:2376-2386.
34. Schrag M, McAuley G, Pomakian J, Jiffry A, Tung S, Mueller C, et al. Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study. Acta Neuropathol. 2010;119:291-302.
35. Pettersen JA, Sathiyamoorthy G, Gao FQ, Szilagyi G, Nadkarni NK, St George-Hyslop P, et al. Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol. 2008;65:790-795.
36. Goos JD, van der Flier WM, Knol DL, Pouwels PJ, Scheltens P, Barkhof F, et al. Clinical relevance of improved microbleed detection by susceptibility-weighted magnetic resonance imaging. Stroke. 2011;42:1894-1900.
37. Conijn MM, Geerlings MI, Biessels GJ, Takahara T, Witkamp TD, Zwanenburg JJ, et al. Cerebral microbleeds on MR imaging: comparison between 1.5 and 7T. Am J Neuroradiol. 2011;32:1043-1049.