메뉴 건너뛰기




Volumn 9, Issue 4, 2013, Pages

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

(27)  Vigant, Frederic a   Lee, Jihye a   Hollmann, Axel b   Tanner, Lukas B c,d   Akyol Ataman, Zeynep a   Yun, Tatyana e   Shui, Guanghou f,m   Aguilar, Hector C g   Zhang, Dong h   Meriwether, David a   Roman Sosa, Gleyder i,n   Robinson, Lindsey R a   Juelich, Terry L e   Buczkowski, Hubert j   Chou, Sunwen k   Castanho, Miguel A R B b   Wolf, Mike C a,o   Smith, Jennifer K e   Banyard, Ashley j   Kielian, Margaret i   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; JL103; LJ001; PHOTOSENSITIZING AGENT; SINGLET OXYGEN; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

EID: 84876852255     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003297     Document Type: Article
Times cited : (90)

References (56)
  • 1
    • 4444256678 scopus 로고    scopus 로고
    • Antivirals and antiviral strategies
    • De Clercq E, (2004) Antivirals and antiviral strategies. Nat Rev Microbiol 2: 704-720.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 704-720
    • De Clercq, E.1
  • 2
    • 80053145985 scopus 로고    scopus 로고
    • Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential
    • Zasloff M, Adams AP, Beckerman B, Campbell A, Han Z, et al. (2011) Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential. Proc Natl Acad Sci U S A 108: 15978-15983.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 15978-15983
    • Zasloff, M.1    Adams, A.P.2    Beckerman, B.3    Campbell, A.4    Han, Z.5
  • 3
    • 79953216695 scopus 로고    scopus 로고
    • Broad-spectrum antiviral activity including human immunodeficiency and hepatitis C viruses mediated by a novel retinoid thiosemicarbazone derivative
    • Kesel AJ, (2011) Broad-spectrum antiviral activity including human immunodeficiency and hepatitis C viruses mediated by a novel retinoid thiosemicarbazone derivative. Eur J Med Chem 46: 1656-1664.
    • (2011) Eur J Med Chem , vol.46 , pp. 1656-1664
    • Kesel, A.J.1
  • 5
    • 78049306063 scopus 로고    scopus 로고
    • Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses
    • St Vincent MR, Colpitts CC, Ustinov AV, Muqadas M, Joyce MA, et al. (2010) Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses. Proc Natl Acad Sci U S A 107: 17339-17344.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17339-17344
    • St Vincent, M.R.1    Colpitts, C.C.2    Ustinov, A.V.3    Muqadas, M.4    Joyce, M.A.5
  • 6
    • 44349125733 scopus 로고    scopus 로고
    • Arbidol: a broad-spectrum antiviral compound that blocks viral fusion
    • Boriskin YS, Leneva IA, Pecheur EI, Polyak SJ, (2008) Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem 15: 997-1005.
    • (2008) Curr Med Chem , vol.15 , pp. 997-1005
    • Boriskin, Y.S.1    Leneva, I.A.2    Pecheur, E.I.3    Polyak, S.J.4
  • 9
    • 79955559702 scopus 로고    scopus 로고
    • Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)
    • Bonavia A, Franti M, Pusateri Keaney E, Kuhen K, Seepersaud M, et al. (2011) Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV). Proc Natl Acad Sci U S A 108: 6739-6744.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 6739-6744
    • Bonavia, A.1    Franti, M.2    Pusateri Keaney, E.3    Kuhen, K.4    Seepersaud, M.5
  • 10
    • 84859407901 scopus 로고    scopus 로고
    • Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export
    • Zhang L, Das P, Schmolke M, Manicassamy B, Wang Y, et al. (2012) Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. J Cell Biol 196: 315-326.
    • (2012) J Cell Biol , vol.196 , pp. 315-326
    • Zhang, L.1    Das, P.2    Schmolke, M.3    Manicassamy, B.4    Wang, Y.5
  • 12
    • 77954976612 scopus 로고    scopus 로고
    • A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade
    • Aguilar HC, Aspericueta V, Robinson LR, Aanensen KE, Lee B, (2010) A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade. J Virol 84: 8033-8041.
    • (2010) J Virol , vol.84 , pp. 8033-8041
    • Aguilar, H.C.1    Aspericueta, V.2    Robinson, L.R.3    Aanensen, K.E.4    Lee, B.5
  • 13
    • 45849108331 scopus 로고    scopus 로고
    • Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme
    • White JM, Delos SE, Brecher M, Schornberg K, (2008) Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme. Crit Rev Biochem Mol Biol 43: 189-219.
    • (2008) Crit Rev Biochem Mol Biol , vol.43 , pp. 189-219
    • White, J.M.1    Delos, S.E.2    Brecher, M.3    Schornberg, K.4
  • 14
    • 70350340830 scopus 로고    scopus 로고
    • Dealing with low pH: entry and exit of alphaviruses and flaviviruses
    • Sanchez-San Martin C, Liu CY, Kielian M, (2009) Dealing with low pH: entry and exit of alphaviruses and flaviviruses. Trends Microbiol 17: 514-521.
    • (2009) Trends Microbiol , vol.17 , pp. 514-521
    • Sanchez-San Martin, C.1    Liu, C.Y.2    Kielian, M.3
  • 16
    • 55549118226 scopus 로고    scopus 로고
    • Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides
    • Chan R, Uchil PD, Jin J, Shui G, Ott DE, et al. (2008) Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides. J Virol 82: 11228-11238.
    • (2008) J Virol , vol.82 , pp. 11228-11238
    • Chan, R.1    Uchil, P.D.2    Jin, J.3    Shui, G.4    Ott, D.E.5
  • 17
    • 84856707874 scopus 로고    scopus 로고
    • Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane
    • Gerl MJ, Sampaio JL, Urban S, Kalvodova L, Verbavatz JM, et al. (2012) Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane. J Cell Biol 196: 213-221.
    • (2012) J Cell Biol , vol.196 , pp. 213-221
    • Gerl, M.J.1    Sampaio, J.L.2    Urban, S.3    Kalvodova, L.4    Verbavatz, J.M.5
  • 19
    • 61349198340 scopus 로고    scopus 로고
    • Photophysics and photochemistry of photodynamic therapy: fundamental aspects
    • Plaetzer K, Krammer B, Berlanda J, Berr F, Kiesslich T, (2009) Photophysics and photochemistry of photodynamic therapy: fundamental aspects. Lasers Med Sci 24: 259-268.
    • (2009) Lasers Med Sci , vol.24 , pp. 259-268
    • Plaetzer, K.1    Krammer, B.2    Berlanda, J.3    Berr, F.4    Kiesslich, T.5
  • 20
    • 33748476306 scopus 로고    scopus 로고
    • Lipid peroxides promote large rafts: effects of excitation of probes in fluorescence microscopy and electrochemical reactions during vesicle formation
    • Ayuyan AG, Cohen FS, (2006) Lipid peroxides promote large rafts: effects of excitation of probes in fluorescence microscopy and electrochemical reactions during vesicle formation. Biophys J 91: 2172-2183.
    • (2006) Biophys J , vol.91 , pp. 2172-2183
    • Ayuyan, A.G.1    Cohen, F.S.2
  • 21
    • 39949084685 scopus 로고    scopus 로고
    • Translocation as a means of disseminating lipid hydroperoxide-induced oxidative damage and effector action
    • Girotti AW, (2008) Translocation as a means of disseminating lipid hydroperoxide-induced oxidative damage and effector action. Free Radic Biol Med 44: 956-968.
    • (2008) Free Radic Biol Med , vol.44 , pp. 956-968
    • Girotti, A.W.1
  • 23
    • 84861792510 scopus 로고    scopus 로고
    • Extracorporeal photopheresis: Clinical use so far
    • Sanford KW, Balogun RA, (2012) Extracorporeal photopheresis: Clinical use so far. J Clin Apher 27: 126-31.
    • (2012) J Clin Apher , vol.27 , pp. 126-131
    • Sanford, K.W.1    Balogun, R.A.2
  • 24
    • 41249087693 scopus 로고    scopus 로고
    • Photopheresis in HIV-1 infected patients utilizing benzoporphyrin derivative (BPD) verteporfin and light
    • Bernstein ZP, Dougherty T, Gollnick S, Schwartz SA, Mahajan SD, et al. (2008) Photopheresis in HIV-1 infected patients utilizing benzoporphyrin derivative (BPD) verteporfin and light. Curr HIV Res 6: 152-163.
    • (2008) Curr HIV Res , vol.6 , pp. 152-163
    • Bernstein, Z.P.1    Dougherty, T.2    Gollnick, S.3    Schwartz, S.A.4    Mahajan, S.D.5
  • 25
    • 47349090837 scopus 로고    scopus 로고
    • Pathogen reduction of blood components
    • Solheim BG, (2008) Pathogen reduction of blood components. Transfus Apher Sci 39: 75-82.
    • (2008) Transfus Apher Sci , vol.39 , pp. 75-82
    • Solheim, B.G.1
  • 27
    • 0027389005 scopus 로고
    • Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation
    • Lenard J, Rabson A, Vanderoef R, (1993) Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A 90: 158-162.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 158-162
    • Lenard, J.1    Rabson, A.2    Vanderoef, R.3
  • 32
    • 77649096724 scopus 로고    scopus 로고
    • Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping
    • Wang F, Han Y, Lim CS, Lu Y, Wang J, et al. (2010) Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping. Nature 463: 1061-1065.
    • (2010) Nature , vol.463 , pp. 1061-1065
    • Wang, F.1    Han, Y.2    Lim, C.S.3    Lu, Y.4    Wang, J.5
  • 33
    • 81955164771 scopus 로고    scopus 로고
    • Tuning upconversion through energy migration in core'Äìshell nanoparticles
    • Wang F, Deng R, Wang J, Wang Q, Han Y, et al. (2011) Tuning upconversion through energy migration in core'Äìshell nanoparticles. Nat Mater 10: 968-973.
    • (2011) Nat Mater , vol.10 , pp. 968-973
    • Wang, F.1    Deng, R.2    Wang, J.3    Wang, Q.4    Han, Y.5
  • 34
    • 84870294469 scopus 로고    scopus 로고
    • In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
    • Idris NM, Gnanasammandhan MK, Zhang J, Ho PC, Mahendran R, et al. (2012) In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nat Med 18: 1580-1585.
    • (2012) Nat Med , vol.18 , pp. 1580-1585
    • Idris, N.M.1    Gnanasammandhan, M.K.2    Zhang, J.3    Ho, P.C.4    Mahendran, R.5
  • 35
    • 0027510261 scopus 로고
    • Lysolipids reversibly inhibit Ca(2+)-, GTP- and pH-dependent fusion of biological membranes
    • Chernomordik LV, Vogel SS, Sokoloff A, Onaran HO, Leikina EA, et al. (1993) Lysolipids reversibly inhibit Ca(2+)-, GTP- and pH-dependent fusion of biological membranes. FEBS Lett 318: 71-76.
    • (1993) FEBS Lett , vol.318 , pp. 71-76
    • Chernomordik, L.V.1    Vogel, S.S.2    Sokoloff, A.3    Onaran, H.O.4    Leikina, E.A.5
  • 36
    • 78049360426 scopus 로고    scopus 로고
    • Positive reinforcement for viruses
    • Vigant F, Jung M, Lee B, (2010) Positive reinforcement for viruses. Chem Biol 17: 1049-1051.
    • (2010) Chem Biol , vol.17 , pp. 1049-1051
    • Vigant, F.1    Jung, M.2    Lee, B.3
  • 37
    • 78049318430 scopus 로고    scopus 로고
    • Driving a wedge between viral lipids blocks infection
    • Melikyan GB, (2010) Driving a wedge between viral lipids blocks infection. Proc Natl Acad Sci U S A 107: 17069-17070.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17069-17070
    • Melikyan, G.B.1
  • 38
    • 24644498035 scopus 로고    scopus 로고
    • Synthesis of hydroxy and methoxy perylene quinones, their spectroscopic and computational characterization, and their antiviral activity
    • Krishnamoorthy G, Webb SP, Nguyen T, Chowdhury PK, Halder M, et al. (2005) Synthesis of hydroxy and methoxy perylene quinones, their spectroscopic and computational characterization, and their antiviral activity. Photochem Photobiol 81: 924-933.
    • (2005) Photochem Photobiol , vol.81 , pp. 924-933
    • Krishnamoorthy, G.1    Webb, S.P.2    Nguyen, T.3    Chowdhury, P.K.4    Halder, M.5
  • 39
    • 37049080392 scopus 로고
    • Experimental correction for the inner-filter effect in fluorescence spectra
    • Kubista M, (1994) Experimental correction for the inner-filter effect in fluorescence spectra. Analyst 119: 417-419.
    • (1994) Analyst , vol.119 , pp. 417-419
    • Kubista, M.1
  • 40
    • 0034667871 scopus 로고    scopus 로고
    • How to measure and analyze tryptophan fluorescence in membranes properly, and why bother?
    • Ladokhin AS, Jayasinghe S, White SH, (2000) How to measure and analyze tryptophan fluorescence in membranes properly, and why bother? Anal Biochem 285: 235-245.
    • (2000) Anal Biochem , vol.285 , pp. 235-245
    • Ladokhin, A.S.1    Jayasinghe, S.2    White, S.H.3
  • 41
    • 0038392423 scopus 로고    scopus 로고
    • Quantifying molecular partition into model systems of biomembranes: an emphasis on optical spectroscopic methods
    • Santos NC, Prieto M, Castanho MA, (2003) Quantifying molecular partition into model systems of biomembranes: an emphasis on optical spectroscopic methods. Biochim Biophys Acta 1612: 123-135.
    • (2003) Biochim Biophys Acta , vol.1612 , pp. 123-135
    • Santos, N.C.1    Prieto, M.2    Castanho, M.A.3
  • 42
    • 79953139417 scopus 로고    scopus 로고
    • Quantitative assessment of peptide-lipid interactions. Ubiquitous fluorescence methodologies
    • Matos PM, Franquelim HG, Castanho MA, Santos NC, (2010) Quantitative assessment of peptide-lipid interactions. Ubiquitous fluorescence methodologies. Biochim Biophys Acta 1798: 1999-2012.
    • (2010) Biochim Biophys Acta , vol.1798 , pp. 1999-2012
    • Matos, P.M.1    Franquelim, H.G.2    Castanho, M.A.3    Santos, N.C.4
  • 43
    • 0033037793 scopus 로고    scopus 로고
    • Simulation study of a gramicidin/lipid bilayer system in excess water and lipid. II. Rates and mechanisms of water transport
    • Chiu SW, Subramaniam S, Jakobsson E, (1999) Simulation study of a gramicidin/lipid bilayer system in excess water and lipid. II. Rates and mechanisms of water transport. Biophys J 76: 1939-1950.
    • (1999) Biophys J , vol.76 , pp. 1939-1950
    • Chiu, S.W.1    Subramaniam, S.2    Jakobsson, E.3
  • 44
    • 43249117737 scopus 로고    scopus 로고
    • Sifuvirtide screens rigid membrane surfaces. establishment of a correlation between efficacy and membrane domain selectivity among HIV fusion inhibitor peptides
    • Franquelim HG, Loura LM, Santos NC, Castanho MA, (2008) Sifuvirtide screens rigid membrane surfaces. establishment of a correlation between efficacy and membrane domain selectivity among HIV fusion inhibitor peptides. J Am Chem Soc 130: 6215-6223.
    • (2008) J Am Chem Soc , vol.130 , pp. 6215-6223
    • Franquelim, H.G.1    Loura, L.M.2    Santos, N.C.3    Castanho, M.A.4
  • 45
    • 1642494594 scopus 로고    scopus 로고
    • Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level
    • Veiga S, Henriques S, Santos NC, Castanho M, (2004) Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level. Biochem J 377: 107-110.
    • (2004) Biochem J , vol.377 , pp. 107-110
    • Veiga, S.1    Henriques, S.2    Santos, N.C.3    Castanho, M.4
  • 46
    • 42149163387 scopus 로고    scopus 로고
    • Enfuvirtide effects on human erythrocytes and lymphocytes functional properties
    • Vieira CR, Castanho M, Saldanha C, Santos NC, (2008) Enfuvirtide effects on human erythrocytes and lymphocytes functional properties. J Pept Sci 14: 448-454.
    • (2008) J Pept Sci , vol.14 , pp. 448-454
    • Vieira, C.R.1    Castanho, M.2    Saldanha, C.3    Santos, N.C.4
  • 47
    • 78649684211 scopus 로고    scopus 로고
    • Efficient singlet oxygen generation by luminescent 2-(2′-thienyl)pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives
    • Lai SW, Liu Y, Zhang D, Wang B, Lok CN, et al. (2010) Efficient singlet oxygen generation by luminescent 2-(2′-thienyl)pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives. Photochem Photobiol 86: 1414-1420.
    • (2010) Photochem Photobiol , vol.86 , pp. 1414-1420
    • Lai, S.W.1    Liu, Y.2    Zhang, D.3    Wang, B.4    Lok, C.N.5
  • 48
    • 80053205338 scopus 로고    scopus 로고
    • Enhancement by LDL of transfer of L-4F and oxidized lipids to HDL in C57BL/6J mice and human plasma
    • Meriwether D, Imaizumi S, Grijalva V, Hough G, Vakili L, et al. (2011) Enhancement by LDL of transfer of L-4F and oxidized lipids to HDL in C57BL/6J mice and human plasma. J Lipid Res 52: 1795-1809.
    • (2011) J Lipid Res , vol.52 , pp. 1795-1809
    • Meriwether, D.1    Imaizumi, S.2    Grijalva, V.3    Hough, G.4    Vakili, L.5
  • 49
    • 79955780874 scopus 로고    scopus 로고
    • Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys?
    • Shui G, Stebbins JW, Lam BD, Cheong WF, Lam SM, et al. (2011) Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys? PLoS One 6: e19731.
    • (2011) PLoS One , vol.6
    • Shui, G.1    Stebbins, J.W.2    Lam, B.D.3    Cheong, W.F.4    Lam, S.M.5
  • 50
    • 44449119583 scopus 로고    scopus 로고
    • Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein
    • Davis B, Koster G, Douet LJ, Scigelova M, Woffendin G, et al. (2008) Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein. J Biol Chem 283: 6428-6437.
    • (2008) J Biol Chem , vol.283 , pp. 6428-6437
    • Davis, B.1    Koster, G.2    Douet, L.J.3    Scigelova, M.4    Woffendin, G.5
  • 51
    • 33646447520 scopus 로고    scopus 로고
    • N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry
    • Aguilar HC, Matreyek KA, Filone CM, Hashimi ST, Levroney EL, et al. (2006) N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry. J Virol 80: 4878-4889.
    • (2006) J Virol , vol.80 , pp. 4878-4889
    • Aguilar, H.C.1    Matreyek, K.A.2    Filone, C.M.3    Hashimi, S.T.4    Levroney, E.L.5
  • 52
    • 26444506252 scopus 로고    scopus 로고
    • Domain III from class II fusion proteins functions as a dominant-negative inhibitor of virus membrane fusion
    • Liao M, Kielian M, (2005) Domain III from class II fusion proteins functions as a dominant-negative inhibitor of virus membrane fusion. J Cell Biol 171: 111-120.
    • (2005) J Cell Biol , vol.171 , pp. 111-120
    • Liao, M.1    Kielian, M.2
  • 53
    • 0015230409 scopus 로고
    • Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion
    • Lehrer SS, (1971) Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. Biochemistry 10: 3254-3263.
    • (1971) Biochemistry , vol.10 , pp. 3254-3263
    • Lehrer, S.S.1
  • 54
    • 0024280716 scopus 로고
    • Structure of fully hydrated bilayer dispersions
    • Nagle JF, Wiener MC, (1988) Structure of fully hydrated bilayer dispersions. Biochim Biophys Acta 942: 1-10.
    • (1988) Biochim Biophys Acta , vol.942 , pp. 1-10
    • Nagle, J.F.1    Wiener, M.C.2
  • 55
    • 0032537597 scopus 로고    scopus 로고
    • Interaction of the major epitope region of HIV protein gp41 with membrane model systems. A fluorescence spectroscopy study
    • Santos NC, Prieto M, Castanho MA, (1998) Interaction of the major epitope region of HIV protein gp41 with membrane model systems. A fluorescence spectroscopy study. Biochemistry 37: 8674-8682.
    • (1998) Biochemistry , vol.37 , pp. 8674-8682
    • Santos, N.C.1    Prieto, M.2    Castanho, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.